JTP-70902

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596307

CAS#: 871696-49-0

Description: JTP-70902 is a protein kinase inhibitor and antineoplastic agent.

Chemical Structure

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JTP-70902
CAS# 871696-49-0
Instruction

Theoretical Analysis

MedKoo Cat#: 596307
Name: JTP-70902
CAS#: 871696-49-0
Chemical Formula: C24H21BrFN5O5S
Exact Mass: 589.04
Molecular Weight: 590.420
Elemental Analysis: C, 48.82; H, 3.59; Br, 13.53; F, 3.22; N, 11.86; O, 13.55; S, 5.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JTP-70902; JTP 70902; JTP70902;

IUPAC/Chemical Name: N-(3-(5-((4-bromo-2-fluorophenyl)amino)-3-cyclopropyl-8-methyl-2,4,7-trioxo-3,4,7,8-tetrahydropyrido[2,3-d]pyrimidin-1(2H)-yl)phenyl)methanesulfonamide

InChi Key: PDRPNIUQNAWRSA-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H21BrFN5O5S/c1-29-20(32)12-19(27-18-9-6-13(25)10-17(18)26)21-22(29)30(24(34)31(23(21)33)15-7-8-15)16-5-3-4-14(11-16)28-37(2,35)36/h3-6,9-12,15,27-28H,7-8H2,1-2H3

SMILES Code: CS(=O)(NC1=CC=CC(N(C2=C(C(NC3=CC=C(Br)C=C3F)=CC(N2C)=O)C(N4C5CC5)=O)C4=O)=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 590.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Matsui TA, Murata H, Sowa Y, Sakabe T, Koto K, Horie N, Tsuji Y, Sakai T, Kubo T. A novel MEK1/2 inhibitor induces G1/S cell cycle arrest in human fibrosarcoma cells. Oncol Rep. 2010 Aug;24(2):329-33. PubMed PMID: 20596617.

2: Yamaguchi T, Yoshida T, Kurachi R, Kakegawa J, Hori Y, Nanayama T, Hayakawa K, Abe H, Takagi K, Matsuzaki Y, Koyama M, Yogosawa S, Sowa Y, Yamori T, Tajima N, Sakai T. Identification of JTP-70902, a p15(INK4b)-inductive compound, as a novel MEK1/2 inhibitor. Cancer Sci. 2007 Nov;98(11):1809-16. Epub 2007 Sep 2. PubMed PMID: 17784872.