WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596306
Description: JTK-101 is a potent and selective inhibitor of Tat-dependent HIV-1 replication.
MedKoo Cat#: 596306
Chemical Formula: C25H23N3O3
Exact Mass: 413.1739
Molecular Weight: 413.47
Elemental Analysis: C, 72.62; H, 5.61; N, 10.16; O, 11.61
This product is not in stock, which may be available by custom synthesis.
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Synonym: JTK-101; JTK-1011;
IUPAC/Chemical Name: 4-((9-methoxy-4-oxo-3,4-dihydrospiro[naphtho[2,1-e][1,3]oxazine-2,4'-piperidin]-1'-yl)methyl)benzonitrile
InChi Key: IFFDMBLMXJBGLL-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H23N3O3/c1-30-20-8-6-19-7-9-21-23(22(19)14-20)31-25(27-24(21)29)10-12-28(13-11-25)16-18-4-2-17(15-26)3-5-18/h2-9,14H,10-13,16H2,1H3,(H,27,29)
SMILES Code: N#CC1=CC=C(CN2CCC(N3)(CC2)OC4=C5C=C(OC)C=CC5=CC=C4C3=O)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 413.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wang X, Yamataka K, Okamoto M, Ikeda S, Baba M. Potent and selective inhibition of Tat-dependent HIV-1 replication in chronically infected cells by a novel naphthalene derivative JTK-101. Antivir Chem Chemother. 2007;18(4):201-11. PubMed PMID: 17907378.