JTH-601 free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596300

CAS#: 171277-06-8

Description: JTH-601 free base is an alpha 1 adenergic recepor anagonist.


Chemical Structure

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JTH-601 free base
CAS# 171277-06-8

Theoretical Analysis

MedKoo Cat#: 596300
Name: JTH-601 free base
CAS#: 171277-06-8
Chemical Formula: C24H35NO4
Exact Mass: 401.2566
Molecular Weight: 401.54
Elemental Analysis: C, 71.79; H, 8.79; N, 3.49; O, 15.94

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JTH-601; JTH-601 free base;

IUPAC/Chemical Name: 3-(((2-(4-hydroxy-2-isopropyl-5-methylphenoxy)ethyl)(methyl)amino)methyl)-4-methoxy-2,5,6-trimethylphenol

InChi Key: VXLRYJNESHCVDX-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H35NO4/c1-14(2)19-12-21(26)15(3)11-22(19)29-10-9-25(7)13-20-18(6)23(27)16(4)17(5)24(20)28-8/h11-12,14,26-27H,9-10,13H2,1-8H3

SMILES Code: OC1=C(C)C(C)=C(OC)C(CN(CCOC2=CC(C)=C(O)C=C2C(C)C)C)=C1C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 401.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Nobata K, Fujimura M, Ishiura Y, Hirose T, Furusyou S, Myou S, Kurashima K, Kasahara K, Nakao S. Alpha(1L)-, but not alpha(1H)-, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivo. Eur J Pharmacol. 2002 Sep 27;452(1):97-104. PubMed PMID: 12323390.

2: Hirai T, Tsuru H, Tanimitsu N, Yajin K, Sasa M. Effect of JTH-601, a putative alpha(1L)-adrenoceptor antagonist, on guinea pig nasal mucosa vasculature. Eur J Pharmacol. 2001 Mar 23;416(1-2):141-4. PubMed PMID: 11282123.

3: Qiao X, Norota I, Endoh M. Pharmacological characteristics of inhibitory action of the selective alpha1-antagonist JTH-601 on the positive inotropic effect mediated by alpha1-adrenoceptors in isolated rabbit papillary muscle. Jpn J Pharmacol. 2000 Nov;84(3):301-9. PubMed PMID: 11138731.

4: Yamada S, Okura T, Kimura R, Deguchi Y, Suzuki Y, Kobayashi T, Aisaka K. Disposition and alpha(1)-adrenoceptor binding characteristics of JTH-601 and its metabolites in rat tissues. Drug Metab Dispos. 2000 Dec;28(12):1487-92. PubMed PMID: 11095588.

5: Takahashi M, Taniguchi T, Kanamaru H, Okada K, Muramatsu I. Pharmacological characterization of [3H]-JTH-601, a novel alpha1-adrenoceptor antagonist: binding to recombinant human alpha1-adrenoceptors and human prostates. Life Sci. 2000 Oct 6;67(20):2443-51. PubMed PMID: 11065167.

6: Suzuki Y, Moriyama N, Okaya Y, Kanada A, Nishimatsu H, Kawabe K, Aisaka K. Distribution of alpha1L-adrenoceptors in canine prostate: characterization by quantitative autoradiography. J Pharm Pharmacol. 2000 Jun;52(6):653-7. PubMed PMID: 10875541.

7: Suzuki Y, Kanada A, Okaya Y, Aisaka K. Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs. Eur J Pharmacol. 2000 Apr 7;394(1):123-30. PubMed PMID: 10771044.

8: Suzuki Y, Kanada A, Okaya Y, Kurahashi Y, Kogayu M, Kobayashi T, Aisaka K. Prostate selectivity of JTH-601-G1, an active metabolite of JTH-601, in dogs. BJU Int. 2000 Mar;85(4):542-50. PubMed PMID: 10691841.

9: Suzuki Y, Moriyama N, Kanada A, Okaya Y, Kawabe K, Aisaka K. The role of alpha 1L-adrenoceptor in rat urinary bladder: comparison between young adult and aged rats. Life Sci. 1999;65(24):2553-9. PubMed PMID: 10619363.

10: Suzuki Y, Moriyama N, Okaya Y, Nishimatsu H, Kawabe K, Aisaka K. Age-related change of the role of alpha1L-adrenoceptor in canine urethral smooth muscle. Gen Pharmacol. 1999 Oct;33(4):347-54. PubMed PMID: 10523074.

11: Nakamura S, Taniguchi T, Suzuki F, Akagi Y, Muramatsu I. Evaluation of alpha1-adrenoceptors in the rabbit iris: pharmacological characterization and expression of mRNA. Br J Pharmacol. 1999 Jul;127(6):1367-74. PubMed PMID: 10455286; PubMed Central PMCID: PMC1760646.

12: Ohkura T, Yamada S, Tohma A, Kimura R, Aisaka K. Ex vivo and in vivo alpha1-adrenoceptor binding characteristics of a novel alpha1L-adrenoceptor antagonist, JTH-601, in rat tissues. Biol Pharm Bull. 1999 Jul;22(7):687-90. PubMed PMID: 10443463.

13: Suzuki Y, Kanada A, Okaya Y, Aisaka K, Muramatsu I. Effect of JTH-601, a novel alpha1-adrenoceptor antagonist, on the function of lower urinary tract and blood pressure. Eur J Pharmacol. 1999 Jun 25;374(3):495-502. PubMed PMID: 10422795.

14: Stam WB, Van der Graaf PH, Saxena PR. Analysis of alpha 1L-adrenoceptor pharmacology in rat small mesenteric artery. Br J Pharmacol. 1999 Jun;127(3):661-70. PubMed PMID: 10401556; PubMed Central PMCID: PMC1566064.

15: Takahashi M, Taniguchi T, Murata S, Okada K, Moriyama N, Yamazaki S, Muramatsu I. New alpha1-adrenoceptor antagonist, JTH-601, shows more than 10 times higher affinity for human prostates than arteries. J Urol. 1999 Apr;161(4):1350-4. PubMed PMID: 10081906.

16: Kawabe K. Current status of research on prostate-selective alpha 1-antagonists. Br J Urol. 1998 Mar;81 Suppl 1:48-50. Review. PubMed PMID: 9589017.

17: Yamada S, Ohkura T, Kimura R, Kawabe K. In vivo receptor binding of novel alpha1-adrenoceptor antagonists for treatment of benign prostatic hyperplasia. Life Sci. 1998;62(17-18):1585-9. PubMed PMID: 9585140.

18: Muramatsu I, Takita M, Suzuki F, Miyamoto S, Sakamoto S, Ohmura T. Subtype selectivity of a new alpha 1-adrenoceptor antagonist, JTH-601: comparison with prazosin. Eur J Pharmacol. 1996 Apr 4;300(1-2):155-7. PubMed PMID: 8741183.