WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596298
Description: JS-38 is a synthetic version of a metabolite isolated from Xenorhabdus sp.
MedKoo Cat#: 596298
Chemical Formula: C22H14F6N2O4S2
Exact Mass: 548.0299
Molecular Weight: 548.47
Elemental Analysis: C, 48.18; H, 2.57; F, 20.78; N, 5.11; O, 11.67; S, 11.69
This product is not in stock, which may be available by custom synthesis.
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Synonym: JS-38; JS 38; JS38;
IUPAC/Chemical Name: N-(4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)-3,5-bis(trifluoromethyl)benzamide
InChi Key: QOWQCUJERUFFPS-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H14F6N2O4S2/c1-33-13-3-4-14(16(8-13)34-2)30-15-9-35-36-18(15)17(20(30)32)29-19(31)10-5-11(21(23,24)25)7-12(6-10)22(26,27)28/h3-9H,1-2H3,(H,29,31)
SMILES Code: O=C(NC1=C2C(N(C3=CC=C(OC)C=C3OC)C1=O)=CSS2)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 548.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Liu MY, Xiao L, Chen GH, Wang YX, Xiong WX, Li F, Liu Y, Huang XL, Deng YF, Zhang Z, Sun HY, Liu QH, Yin M. Oral JS-38, a metabolite from Xenorhabdus sp., has both anti-tumor activity and the ability to elevate peripheral neutrophils. Chin J Nat Med. 2014 Oct;12(10):768-76. doi: 10.1016/S1875-5364(14)60117-5. Epub 2014 Oct 31. PubMed PMID: 25443370.
2: Zhang H, Liu Q, Fan T, Fang Y, Li Y, Wang G. Metabolism and disposition of a novel antineoplastic JS-38 (Benzamide, N-[4-(2,4-dimethoxyphenyl)-4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl]-3,5- bis (trifluoromethyl)-(9Cl)) in rats. Eur J Drug Metab Pharmacokinet. 2012 Mar;37(1):45-56. doi: 10.1007/s13318-011-0055-8. Epub 2011 Jul 30. PubMed PMID: 21805208.
3: Ng HZ, Fang Y, Li Y, Fan TT, Qin Y, Liu QH. The pharmacokinetics of JS-38, a novel antineoplastic drug, in rats. Eur J Drug Metab Pharmacokinet. 2008 Jul-Sep;33(3):143-8. PubMed PMID: 19007039.