WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596298

CAS#: 608131-69-7

Description: JS-38 is a synthetic version of a metabolite isolated from Xenorhabdus sp.

Chemical Structure

CAS# 608131-69-7

Theoretical Analysis

MedKoo Cat#: 596298
Name: JS-38
CAS#: 608131-69-7
Chemical Formula: C22H14F6N2O4S2
Exact Mass: 548.0299
Molecular Weight: 548.47
Elemental Analysis: C, 48.18; H, 2.57; F, 20.78; N, 5.11; O, 11.67; S, 11.69

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JS-38; JS 38; JS38;

IUPAC/Chemical Name: N-(4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)-3,5-bis(trifluoromethyl)benzamide


InChi Code: InChI=1S/C22H14F6N2O4S2/c1-33-13-3-4-14(16(8-13)34-2)30-15-9-35-36-18(15)17(20(30)32)29-19(31)10-5-11(21(23,24)25)7-12(6-10)22(26,27)28/h3-9H,1-2H3,(H,29,31)

SMILES Code: O=C(NC1=C2C(N(C3=CC=C(OC)C=C3OC)C1=O)=CSS2)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 548.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Liu MY, Xiao L, Chen GH, Wang YX, Xiong WX, Li F, Liu Y, Huang XL, Deng YF, Zhang Z, Sun HY, Liu QH, Yin M. Oral JS-38, a metabolite from Xenorhabdus sp., has both anti-tumor activity and the ability to elevate peripheral neutrophils. Chin J Nat Med. 2014 Oct;12(10):768-76. doi: 10.1016/S1875-5364(14)60117-5. Epub 2014 Oct 31. PubMed PMID: 25443370.

2: Zhang H, Liu Q, Fan T, Fang Y, Li Y, Wang G. Metabolism and disposition of a novel antineoplastic JS-38 (Benzamide, N-[4-(2,4-dimethoxyphenyl)-4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl]-3,5- bis (trifluoromethyl)-(9Cl)) in rats. Eur J Drug Metab Pharmacokinet. 2012 Mar;37(1):45-56. doi: 10.1007/s13318-011-0055-8. Epub 2011 Jul 30. PubMed PMID: 21805208.

3: Ng HZ, Fang Y, Li Y, Fan TT, Qin Y, Liu QH. The pharmacokinetics of JS-38, a novel antineoplastic drug, in rats. Eur J Drug Metab Pharmacokinet. 2008 Jul-Sep;33(3):143-8. PubMed PMID: 19007039.