Benfluorex
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MedKoo CAT#: 596290

CAS#: 23602-78-0

Description: Benfluorex Hydrochloride, a hypolipidemic and an anorectic agent, has been considered to treat people with type 2 diabetes by improving glycemic control and decreasing insulin resistance.


Price and Availability

Size Price Shipping out time Quantity
5g USD 360 2 weeks
50g USD 1560 2 weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-10. Prices are subject to change without notice.

Benfluorex purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596290
Name: Benfluorex
CAS#: 23602-78-0
Chemical Formula: C19H20F3NO2
Exact Mass: 351.1446
Molecular Weight: 351.36
Elemental Analysis: C, 64.95; H, 5.74; F, 16.22; N, 3.99; O, 9.11


Synonym: Benfluorex; BRN 4152887; JP 992; SE 780; Minolip; Mediator; EINECS 245-777-9; Benfluramate;

IUPAC/Chemical Name: 2-((1-(3-(trifluoromethyl)phenyl)propan-2-yl)amino)ethyl benzoate

InChi Key: CJAVTWRYCDNHSM-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H20F3NO2/c1-14(12-15-6-5-9-17(13-15)19(20,21)22)23-10-11-25-18(24)16-7-3-2-4-8-16/h2-9,13-14,23H,10-12H2,1H3

SMILES Code: FC(C1=CC(CC(NCCOC(C2=CC=CC=C2)=O)C)=CC=C1)(F)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

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2: Eugène M, Bruneval P, Bonnet N, Attias D. Benfluorex-induced severe primary tricuspid and mitral regurgitation requiring a double-valve replacement. Eur J Cardiothorac Surg. 2018 Feb 12. doi: 10.1093/ejcts/ezy032. [Epub ahead of print] PubMed PMID: 29444226.

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4: Harris AP, Ismail KA, Nunez M, Martopullo I, Lencinas A, Selmin OI, Runyan RB. Trichloroethylene perturbs HNF4a expression and activity in the developing chick heart. Toxicol Lett. 2018 Mar 15;285:113-120. doi: 10.1016/j.toxlet.2017.12.027. Epub 2018 Jan 4. PubMed PMID: 29306027; PubMed Central PMCID: PMC5803365.

5: Wang SL, Dong WB, Dong XL, Zhu WM, Wang FF, Han F, Yan X. Comparison of twelve single-drug regimens for the treatment of type 2 diabetes mellitus. Oncotarget. 2017 Aug 16;8(42):72700-72713. doi: 10.18632/oncotarget.20282. eCollection 2017 Sep 22. PubMed PMID: 29069819; PubMed Central PMCID: PMC5641162.

6: Dyer O. France to prosecute its drug regulator and Servier in scandal over diabetes drug. BMJ. 2017 Sep 11;358:j4231. doi: 10.1136/bmj.j4231. PubMed PMID: 28893847.

7: Ayme-Dietrich E, Lawson R, Côté F, de Tapia C, Da Silva S, Ebel C, Hechler B, Gachet C, Guyonnet J, Rouillard H, Stoltz J, Quentin E, Banas S, Daubeuf F, Frossard N, Gasser B, Mazzucotelli JP, Hermine O, Maroteaux L, Monassier L. The role of 5-HT(2B) receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors. Br J Pharmacol. 2017 Nov;174(22):4123-4139. doi: 10.1111/bph.13981. Epub 2017 Oct 15. PubMed PMID: 28806488; PubMed Central PMCID: PMC5680644.

8: Nau JY. Miscellanées sexuelles, hypertensives et cinématographiques. Rev Med Suisse. 2016 Sep 21;12(531):1590-1591. French. PubMed PMID: 28678460.

9: Baufreton C, Bruneval P, Rousselet MC, Ennezat PV, Fouquet O, Giraud R, Banfi C. Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report. Medicine (Baltimore). 2017 Jan;96(2):e4985. doi: 10.1097/MD.0000000000004985. PubMed PMID: 28079786; PubMed Central PMCID: PMC5266148.

10: Scheffer P, Guy-Coichard C, Outh-Gauer D, Calet-Froissart Z, Boursier M, Mintzes B, Borde JS. Conflict of Interest Policies at French Medical Schools: Starting from the Bottom. PLoS One. 2017 Jan 9;12(1):e0168258. doi: 10.1371/journal.pone.0168258. eCollection 2017. PubMed PMID: 28068362; PubMed Central PMCID: PMC5221756.

11: Le Ven F, Alavi Z, Jobic Y, Etienne Y, Didier R, Porcher R. Drug-Induced- or Rheumatic- Valvular Heart Disease in Patients Exposed to Benfluorex? PLoS One. 2016 Aug 3;11(8):e0160011. doi: 10.1371/journal.pone.0160011. eCollection 2016. PubMed PMID: 27487042; PubMed Central PMCID: PMC4972394.

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13: Ennezat PV, Bruneval P, Czitrom D, Gueffet JP, Piriou N, Trochu JN, Patra O, Blanchard-Lemoine B, du Fretay XH, Nazeyrollas P, Assoun B, Jobic Y, Brochet E, Bogino E, Roudaut R, Augier C, Greffe L, Petit-Eisenmann H, Dambrin C, Chavanon O, Guillou L, Grisoli D, Morera P, Banfi C, Remadi JP, Fabre O, Vincentelli A, Lantuejoul S, Ikoli JF, Copin MC, Malergue MC, Maréchaux S, Tribouilloy C. Drug-induced aortic valve stenosis: An under recognized entity. Int J Cardiol. 2016 Oct 1;220:429-34. doi: 10.1016/j.ijcard.2016.06.112. Epub 2016 Jun 23. PubMed PMID: 27390966.

14: Bagheri H, Lacroix I, Guitton E, Damase-Michel C, Montastruc JL. Cyberpharmacovigilance: What is the usefulness of the social networks in pharmacovigilance? Therapie. 2016 Apr;71(2):235-9. doi: 10.1016/j.therap.2015.09.002. Epub 2016 Mar 28. English, French. PubMed PMID: 27080844.

15: Degrassat-Théas A, Bocquet F, Sinègre M, Peigné J, Paubel P. The "Temporary Recommendations for Use": A dual-purpose regulatory framework for off-label drug use in France. Health Policy. 2015 Nov;119(11):1399-405. doi: 10.1016/j.healthpol.2015.09.003. Epub 2015 Sep 25. PubMed PMID: 26455642.

16: Russo G, Barbato F, Grumetto L. A validated LC/UV method for the determination of four adulterating drugs in herbal slimming capsules. J Pharm Biomed Anal. 2016 Jan 5;117:436-45. doi: 10.1016/j.jpba.2015.09.027. Epub 2015 Sep 26. PubMed PMID: 26454104.

17: Szymanski C, Maréchaux S, Bruneval P, Andréjak M, de Montpréville VT, Belli E, Tribouilloy C. Sub-aortic obstruction of left ventricular outflow tract secondary to benfluorex-induced endocardial fibrosis. Int J Cardiol Heart Vasc. 2015 Sep 21;9:67-69. doi: 10.1016/j.ijcha.2015.09.003. eCollection 2015 Dec 7. PubMed PMID: 28785710; PubMed Central PMCID: PMC5497322.

18: Choisy H, Ségal A. [From ergot of rye to Mediator]. Hist Sci Med. 2014 Oct-Dec;48(4):537-9. French. PubMed PMID: 25962221.

19: Ennezat PV, Bruneval P, Maréchaux S, Bellemin JP, Senellart F, Arnaud-Crozat E, Ramadan R, Obadia JF, Touati G, Fleury JP, Tribouilloy C. Operative finding of aortic cusp prolapse in benfluorex-induced aortic regurgitation. Int J Cardiol. 2015;186:231-2. doi: 10.1016/j.ijcard.2015.03.191. Epub 2015 Mar 18. PubMed PMID: 25828122.

20: Malergue MC, Bruneval P, Czitrom D, Ennezat PV. Fatal dynamic mitral regurgitation as a presentation of benfluorex-Induced valvular heart toxicity. Int J Cardiol. 2015 Apr 1;184:549-51. doi: 10.1016/j.ijcard.2015.03.009. Epub 2015 Mar 3. PubMed PMID: 25767015.