Jolkinol A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596273

CAS#: 62820-11-5

Description: Jolkinol A is isolated from the seeds of Euphorbia lathyris L. It can inhibit both MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) cell lines.

Chemical Structure

Jolkinol A
CAS# 62820-11-5

Theoretical Analysis

MedKoo Cat#: 596273
Name: Jolkinol A
CAS#: 62820-11-5
Chemical Formula: C29H36O6
Exact Mass: 480.2512
Molecular Weight: 480.6
Elemental Analysis: C, 72.48; H, 7.55; O, 19.97

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Jolkinol A;

IUPAC/Chemical Name: (Z)-2-hydroxy-6-(hydroxymethyl)-3,8,8,10a-tetramethyl-5-oxo-1a,1b,2,3,4,5,7a,8,8a,9,10,10a-dodecahydro-4aH-cyclopenta[3,4]cyclopropa[8,9]cycloundeca[1,2-b]oxiren-4a-yl cinnamate


InChi Code: InChI=1S/C29H36O6/c1-17-15-29(34-22(31)11-10-18-8-6-5-7-9-18)23(24(17)32)26-28(4,35-26)13-12-20-21(27(20,2)3)14-19(16-30)25(29)33/h5-11,14,17,20-21,23-24,26,30,32H,12-13,15-16H2,1-4H3/b11-10+,19-14-

SMILES Code: CC1CC2(OC(/C=C/c3ccccc3)=O)C(C4C(CCC5C(/C=C(CO)\C2=O)C5(C)C)(C)O4)C1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 480.6 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Valente C, Pedro M, Ascenso JR, Abreu PM, Nascimento MS, Ferreira MJ. Euphopubescenol and euphopubescene, two new jatrophane polyesters, and lathyrane-type diterpenes from Euphorbia pubescens. Planta Med. 2004 Mar;70(3):244-9. PubMed PMID: 15114502.

2: Adolf W, Hecker E, Becker H. Macrocyclic lathyrane type diterpene esters (jolkinols) from callus cultures and roots of Euphorbia lathyris. Planta Med. 1984 Jun;50(3):259-61. PubMed PMID: 6484031.