Jolkinolide A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596271

CAS#: 37905-07-0

Description: Jolkinolide A is a diterpenoid extracted from the roots of Euphorbia fischeriana Steud.


Chemical Structure

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Jolkinolide A
CAS# 37905-07-0

Theoretical Analysis

MedKoo Cat#: 596271
Name: Jolkinolide A
CAS#: 37905-07-0
Chemical Formula: C20H26O3
Exact Mass: 314.19
Molecular Weight: 314.420
Elemental Analysis: C, 76.40; H, 8.34; O, 15.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Jolkinolide A;

IUPAC/Chemical Name: (1aS,3aR,7aS,7bS,11bR)-4,4,7a,11-tetramethyl-3,3a,4,5,6,7,7a,7b-octahydro-2H-oxireno[2',3':1,10a]phenanthro[3,2-b]furan-10(11bH)-one

InChi Key: OYXDHOVYZKWSRM-QDKUENGFSA-N

InChi Code: InChI=1S/C20H26O3/c1-11-15-12(22-17(11)21)10-14-19(4)8-5-7-18(2,3)13(19)6-9-20(14)16(15)23-20/h10,13-14,16H,5-9H2,1-4H3/t13-,14+,16-,19+,20+/m1/s1

SMILES Code: CC1=C2[C@@H](O3)[C@]3(CC[C@H]4[C@]5(C)CCCC4(C)C)[C@H]5C=C2OC1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 314.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cai D, Zhai W, Zhang Q, Liu J, Sun Y, Liu L, Liu J. Development of matrix solid-phase dispersion coupled with high-performance liquid chromatography for determination of jolkinolide A and jolkinolide B in Euphorbia fischeriana Steud. Nat Prod Res. 2017 Aug;31(15):1805-1811. doi: 10.1080/14786419.2017.1297993. Epub 2017 Mar 24. PubMed PMID: 28338342.

2: Shen L, Zhang SQ, Liu L, Sun Y, Wu YX, Xie LP, Liu JC. Jolkinolide A and Jolkinolide B Inhibit Proliferation of A549 Cells and Activity of Human Umbilical Vein Endothelial Cells. Med Sci Monit. 2017 Jan 14;23:223-237. PubMed PMID: 28087861; PubMed Central PMCID: PMC5256368.

3: Lai JZ, Zhang MH, Wu YC, Zhang DY, Wu XM, Hua WY. ent-Abietane Lactones from Euphorbia. Mini Rev Med Chem. 2017;17(4):380-397. Review. PubMed PMID: 27670580.

4: Wang Y, Xu X, Wang HB, Wu D, Li XO, Peng Q, Liu N, Sun WC. 17-Hydroxy-jolkinolide A inhibits osteoclast differentiation through suppressing the activation of NF-κB and MAPKs. Int Immunopharmacol. 2015 Dec;29(2):513-520. doi: 10.1016/j.intimp.2015.10.004. Epub 2015 Oct 9. PubMed PMID: 26456501.

5: Wang JL, Wang YQ, Li T, Wang H, Zhao M, Zhang SJ. [Study on the chemical constituents from fresh roots of Euphorbia fischeriana]. Zhong Yao Cai. 2010 Sep;33(9):1406-9. Chinese. PubMed PMID: 21243769.

6: Shi HM, Williams ID, Sung HH, Zhu HX, Ip NY, Min ZD. Cytotoxic diterpenoids from the roots of Euphorbia ebracteolata. Planta Med. 2005 Apr;71(4):349-54. PubMed PMID: 15856412.

7: Liu GF. [Isolation and identification of antitumor constituents of diterpenoids lactone in Euphorbia fischeriana Steud]. Zhong Yao Tong Bao. 1988 May;13(5):35-6, 63. Chinese. PubMed PMID: 3197209.