Johnstonol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596268

CAS#: 35671-09-1

Description: Johnstonol is an unusual halogenated epoxide from the red alga.


Chemical Structure

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Johnstonol
CAS# 35671-09-1

Theoretical Analysis

MedKoo Cat#: 596268
Name: Johnstonol
CAS#: 35671-09-1
Chemical Formula: C15H21Br2ClO3
Exact Mass: 441.9546
Molecular Weight: 444.58
Elemental Analysis: C, 40.52; H, 4.76; Br, 35.95; Cl, 7.97; O, 10.80

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Johnstonol;

IUPAC/Chemical Name: (1aR,2R,3R,4aS,6S,7S,8aR,8bS)-3,7-dibromo-6-chloro-6,8b,9,9-tetramethyloctahydro-6H-3,8a-methanobenzo[b]oxireno[2,3-d]oxepin-2-ol

InChi Key: GQTRVJJQEJXMFF-WJZNTHCVSA-N

InChi Code: InChI=1S/C15H21Br2ClO3/c1-11(2)14-5-7(16)12(3,18)6-8(14)20-15(11,17)9(19)10-13(14,4)21-10/h7-10,19H,5-6H2,1-4H3/t7-,8-,9+,10+,12-,13+,14-,15+/m0/s1

SMILES Code: O[C@H]1[C@@](C2(C)C)(Br)O[C@](C[C@](C)(Cl)[C@@H](Br)C3)([H])[C@@]32[C@@]4(C)[C@]1([H])O4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 444.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ogunremi T, Taylor G, Johnston L, Amaratunga K, Muller M, Coady A, Defalco K, Dunn K, Johnstone J, Smith S, Embree J, Henry B, Stafford J; Infection Prevention; Control Expert Working Group. Mycobacterium chimaera infections in post-operative patients exposed to heater-cooler devices: An overview. Can Commun Dis Rep. 2017 May 4;43(5):107-113. eCollection 2017 May 4. PubMed PMID: 29770074; PubMed Central PMCID: PMC5764710.

2: Thompson EA, Ols S, Miura K, Rausch K, Narum DL, Spångberg M, Juraska M, Wille-Reece U, Weiner A, Howard RF, Long CA, Duffy PE, Johnston L, O'Neil CP, Loré K. TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25. JCI Insight. 2018 May 17;3(10). pii: 120692. doi: 10.1172/jci.insight.120692. [Epub ahead of print] PubMed PMID: 29769448.

3: Kottaram A, Johnston L, Ganella E, Pantelis C, Kotagiri R, Zalesky A. Spatio-temporal dynamics of resting-state brain networks improve single-subject prediction of schizophrenia diagnosis. Hum Brain Mapp. 2018 May 10. doi: 10.1002/hbm.24202. [Epub ahead of print] PubMed PMID: 29749660.

4: Halladay JR, Lenhart KC, Robasky K, Jones W, Homan WF, Cummings DM, Cené CW, Hinderliter AL, Miller CL, Donahue KE, Garcia BA, Keyserling TC, Ammerman AS, Patterson C, DeWalt DA, Johnston LF, Willis MS, Schisler JC. Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations. J Pers Med. 2018 Apr 30;8(2). pii: E16. doi: 10.3390/jpm8020016. PubMed PMID: 29710874.

5: Auld ML, Johnston LM. Getting inTOUCH: outcomes of a knowledge translation intervention for tactile assessment knowledge, barriers, and practice in paediatric therapists working with children with cerebral palsy. Disabil Rehabil. 2018 Apr 25:1-9. doi: 10.1080/09638288.2018.1466202. [Epub ahead of print] PubMed PMID: 29693473.

6: Zhang J, Chen X, Liu P, Zhao J, Sun J, Guan W, Johnston LJ, Levesque CL, Fan P, He T, Zhang G, Ma X. Dietary Clostridium butyricum Induces a Phased Shift in Fecal Microbiota Structure and Increases the Acetic Acid-Producing Bacteria in a Weaned Piglet Model. J Agric Food Chem. 2018 Apr 30. doi: 10.1021/acs.jafc.8b01253. [Epub ahead of print] PubMed PMID: 29683328.

7: English KM, Langley JM, McGeer A, Hupert N, Tellier R, Henry B, Halperin SA, Johnston L, Pourbohloul B. Contact among healthcare workers in the hospital setting: developing the evidence base for innovative approaches to infection control. BMC Infect Dis. 2018 Apr 17;18(1):184. doi: 10.1186/s12879-018-3093-x. PubMed PMID: 29665775; PubMed Central PMCID: PMC5905140.

8: Hakim AJ, Johnston LG, Dittrich S, Prybylski D, Burnett J, Kim E. Defining and surveying key populations at risk of HIV infection: Towards a unified approach to eligibility criteria for respondent-driven sampling HIV biobehavioral surveys. Int J STD AIDS. 2018 Jan 1:956462418763882. doi: 10.1177/0956462418763882. [Epub ahead of print] PubMed PMID: 29629653.

9: Hashmi SK, Lee SJ, Savani BN, Burns L, Wingard JR, Perales MA, Palmer J, Chow E, Meyer E, Marks D, Mohty M, Inamoto Y, Rodriguez C, Nagler A, Sauter C, Komanduri KV, Pidala J, Hamadani M, Johnston L, Shah N, Shaughnessy P, Hamilton BK, Majhail N, Kharfan-Dabaja MA, Schriber J, DeFilipp Z, Tarlock KG, Fanning S, Curtin P, Rizzo JD, Carpenter PA. ASBMT Practice Guidelines Committee Survey on Long-Term Follow-Up Clinics for Hematopoietic Cell Transplant Survivors. Biol Blood Marrow Transplant. 2018 Mar 30. pii: S1083-8791(18)30157-5. doi: 10.1016/j.bbmt.2018.03.023. [Epub ahead of print] PubMed PMID: 29608957.

10: Mullen MG, Hawkins RB, Johnston LE, Shah PM, Turrentine FE, Hedrick TL, Friel CM. Open Surgical Incisions After Colorectal Surgery Improve Quality Metrics, But Do Patients Benefit? Dis Colon Rectum. 2018 May;61(5):622-628. doi: 10.1097/DCR.0000000000001049. PubMed PMID: 29578920; PubMed Central PMCID: PMC5889337.

11: Muffly L, Sheehan K, Armstrong R, Jensen K, Tate K, Rezvani AR, Miklos D, Arai S, Shizuru J, Johnston L, Meyer E, Weng WK, Laport GG, Negrin RS, Strober S, Lowsky R. Infusion of donor-derived CD8(+) memory T cells for relapse following allogeneic hematopoietic cell transplantation. Blood Adv. 2018 Mar 27;2(6):681-690. doi: 10.1182/bloodadvances.2017012104. PubMed PMID: 29572391; PubMed Central PMCID: PMC5873230.

12: Charles EJ, Napoli NJ, Johnston LE, Foster CA, Goode DA, Parker TB, Sharp EA, Barnes L, Young JS. Outcomes after Falls Continue to Worsen Despite Trauma and Geriatric Care Advancements. Am Surg. 2018 Mar 1;84(3):392-397. PubMed PMID: 29559054.

13: Sarvet AL, Wall MM, Keyes KM, Cerdá M, Schulenberg JE, O'Malley PM, Johnston LD, Hasin DS. Recent rapid decrease in adolescents' perception that marijuana is harmful, but no concurrent increase in use. Drug Alcohol Depend. 2018 May 1;186:68-74. doi: 10.1016/j.drugalcdep.2017.12.041. Epub 2018 Mar 1. PubMed PMID: 29550624.

14: Crowhurst JA, Scalia GM, Whitby M, Murdoch D, Robinson BJ, Turner A, Johnston L, Margale S, Natani S, Clarke A, Burstow DJ, Raffel OC, Walters DL. Radiation Exposure of Operators Performing Transesophageal Echocardiography During Percutaneous Structural Cardiac Interventions. J Am Coll Cardiol. 2018 Mar 20;71(11):1246-1254. doi: 10.1016/j.jacc.2018.01.024. PubMed PMID: 29544609.

15: Mertz D, Macri J, Hota S, Amaratunga K, Davis I, Johnston L, Lee B, Pelude L, Science M, Smith S, Wong A; Canadian Nosocomial Infection Surveillance Program (CNISP). Response to Alert on Possible Infections with Mycobacterium chimaera From Contaminated Heater-Cooler Devices in Hospitals Participating in the Canadian Nosocomial Infection Surveillance Program (CNISP). Infect Control Hosp Epidemiol. 2018 Apr;39(4):482-484. doi: 10.1017/ice.2018.24. Epub 2018 Feb 28. PubMed PMID: 29488454.

16: Miller S, Agarwal A, Haddon WB, Johnston L, Arnold G, Wang W, Abboud RJ. Comparison of gait kinetics in total and unicondylar knee replacement surgery. Ann R Coll Surg Engl. 2018 Apr;100(4):267-274. doi: 10.1308/rcsann.2017.0226. Epub 2018 Feb 27. PubMed PMID: 29484928.

17: Scheiber C, Johnston L, Packer M, Gevirtz R, Edwards KS, Palesh O. Heart Rate Variability Markers as Correlates of Survival in Recipients of Hematopoietic Cell Transplantation. Oncol Nurs Forum. 2018 Mar 1;45(2):250-259. doi: 10.1188/18.ONF.250-259. PubMed PMID: 29466350.

18: McCall EM, Alderdice F, Halliday HL, Vohra S, Johnston L. Interventions to prevent hypothermia at birth in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2018 Feb 12;2:CD004210. doi: 10.1002/14651858.CD004210.pub5. Review. PubMed PMID: 29431872.

19: Foster AD, Vicente D, Sexton JJ, Johnston L, Clark N, Leonhardt C, Elster EA, Davis TA, Bradley MJ. Administration of FTY720 during Tourniquet-Induced Limb Ischemia Reperfusion Injury Attenuates Systemic Inflammation. Mediators Inflamm. 2017;2017:4594035. doi: 10.1155/2017/4594035. Epub 2017 Dec 19. PubMed PMID: 29410598; PubMed Central PMCID: PMC5749296.

20: Goo M, Tucker K, Johnston LM. Muscle tone assessments for children aged 0 to 12 years: a systematic review. Dev Med Child Neurol. 2018 Feb 6. doi: 10.1111/dmcn.13668. [Epub ahead of print] Review. PubMed PMID: 29405265.