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MedKoo CAT#: 562807

CAS#: 216691-95-1

Description: Bz-423 is an F1F0-ATPase modulator. It acts by selectively killing autoimmune lymphocytes.

Price and Availability

Size Price Shipping out time Quantity
5mg USD 260 2 Weeks
25mg USD 610 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-10. Prices are subject to change without notice.

Bz-423 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 562807
Name: Bz-423
CAS#: 216691-95-1
Chemical Formula: C27H21ClN2O2
Exact Mass: 440.1292
Molecular Weight: 440.92
Elemental Analysis: C, 73.55; H, 4.80; Cl, 8.04; N, 6.35; O, 7.26

Synonym: Bz-423; Bz 423; Bz423;

IUPAC/Chemical Name: 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one


InChi Code: InChI=1S/C27H21ClN2O2/c1-30-25-13-10-21(28)16-23(25)26(19-8-11-22(31)12-9-19)29-24(27(30)32)15-17-6-7-18-4-2-3-5-20(18)14-17/h2-14,16,24,31H,15H2,1H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Toogood PL. Mitochondrial drugs. Curr Opin Chem Biol. 2008 Aug;12(4):457-63. doi: 10.1016/j.cbpa.2008.06.002. Epub 2008 Jul 2. Review. PubMed PMID: 18602018.

2: Cummings MD, Schubert C, Parks DJ, Calvo RR, LaFrance LV, Lattanze J, Milkiewicz KL, Lu T. Substituted 1,4-benzodiazepine-2,5-diones as alpha-helix mimetic antagonists of the HDM2-p53 protein-protein interaction. Chem Biol Drug Des. 2006 Mar;67(3):201-5. Review. PubMed PMID: 16611213.

3: Kamal A, Reddy KL, Devaiah V, Shankaraiah N, Reddy DR. Recent advances in the solid-phase combinatorial synthetic strategies for the benzodiazepine based privileged structures. Mini Rev Med Chem. 2006 Jan;6(1):53-69. Review. PubMed PMID: 16457632.

4: Villamor N, Montserrat E, Colomer D. Cytotoxic effects of B lymphocytes mediated by reactive oxygen species. Curr Pharm Des. 2004;10(8):841-53. Review. PubMed PMID: 15040354.

5: CHILDRESS SJ, GLUCKMAN MI. 1,4-BENZODIAZEPINES. J Pharm Sci. 1964 Jun;53:577-90. Review. PubMed PMID: 14198427.