Bz-423
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562807

CAS#: 216691-95-1

Description: Bz-423 is an F1F0-ATPase modulator. It acts by selectively killing autoimmune lymphocytes.


Chemical Structure

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Bz-423
CAS# 216691-95-1

Theoretical Analysis

MedKoo Cat#: 562807
Name: Bz-423
CAS#: 216691-95-1
Chemical Formula: C27H21ClN2O2
Exact Mass: 440.13
Molecular Weight: 440.920
Elemental Analysis: C, 73.55; H, 4.80; Cl, 8.04; N, 6.35; O, 7.26

Price and Availability

Size Price Availability Quantity
5mg USD 260
25mg USD 610
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Synonym: Bz-423; Bz 423; Bz423;

IUPAC/Chemical Name: 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one

InChi Key: HIJCSNHREFFOML-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H21ClN2O2/c1-30-25-13-10-21(28)16-23(25)26(19-8-11-22(31)12-9-19)29-24(27(30)32)15-17-6-7-18-4-2-3-5-20(18)14-17/h2-14,16,24,31H,15H2,1H3

SMILES Code: O=C1N(C)C2=CC=C(Cl)C=C2C(C3=CC=C(O)C=C3)=NC1CC4=CC=C5C=CC=CC5=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 440.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Toogood PL. Mitochondrial drugs. Curr Opin Chem Biol. 2008 Aug;12(4):457-63. doi: 10.1016/j.cbpa.2008.06.002. Epub 2008 Jul 2. Review. PubMed PMID: 18602018.

2: Cummings MD, Schubert C, Parks DJ, Calvo RR, LaFrance LV, Lattanze J, Milkiewicz KL, Lu T. Substituted 1,4-benzodiazepine-2,5-diones as alpha-helix mimetic antagonists of the HDM2-p53 protein-protein interaction. Chem Biol Drug Des. 2006 Mar;67(3):201-5. Review. PubMed PMID: 16611213.

3: Kamal A, Reddy KL, Devaiah V, Shankaraiah N, Reddy DR. Recent advances in the solid-phase combinatorial synthetic strategies for the benzodiazepine based privileged structures. Mini Rev Med Chem. 2006 Jan;6(1):53-69. Review. PubMed PMID: 16457632.

4: Villamor N, Montserrat E, Colomer D. Cytotoxic effects of B lymphocytes mediated by reactive oxygen species. Curr Pharm Des. 2004;10(8):841-53. Review. PubMed PMID: 15040354.

5: CHILDRESS SJ, GLUCKMAN MI. 1,4-BENZODIAZEPINES. J Pharm Sci. 1964 Jun;53:577-90. Review. PubMed PMID: 14198427.