JNJ-39758979 2HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596253

CAS#: 1620648-30-7

Description: JNJ-39758979 2HCl is a histamine receptor H4 (HRH4) antagonist.


Chemical Structure

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JNJ-39758979 2HCl
CAS# 1620648-30-7

Theoretical Analysis

MedKoo Cat#: 596253
Name: JNJ-39758979 2HCl
CAS#: 1620648-30-7
Chemical Formula: C11H21Cl2N5
Exact Mass: 293.1174
Molecular Weight: 294.22
Elemental Analysis: C, 44.90; H, 7.19; Cl, 24.10; N, 23.80

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JNJ-39758979 2HCl; JNJ-39758979 dihydrochloride;

IUPAC/Chemical Name: (R)-4-(3-aminopyrrolidin-1-yl)-6-isopropylpyrimidin-2-amine dihydrochloride

InChi Key: KXPWYAVIFCXPRW-YCBDHFTFSA-N

InChi Code: InChI=1S/C11H19N5.2ClH/c1-7(2)9-5-10(15-11(13)14-9)16-4-3-8(12)6-16;;/h5,7-8H,3-4,6,12H2,1-2H3,(H2,13,14,15);2*1H/t8-;;/m1../s1

SMILES Code: CC(c1nc(N)nc(N2CC[C@H](C2)N)c1)C.Cl.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 294.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kollmeier AP, Greenspan A, Xu XL, Silkoff PE, Barnathan E, Loza MJ, Jiang J, Zhou B, Chen B, Thurmond RL. Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of an H(4) R-antagonist (JNJ-39758979) in adults with uncontrolled asthma. Clin Exp Allergy. 2018 Apr 23. doi: 10.1111/cea.13154. [Epub ahead of print] PubMed PMID: 29682796.

2: Köchling H, Schaper K, Wilzopolski J, Gutzmer R, Werfel T, Bäumer W, Kietzmann M, Rossbach K. Combined treatment with H1 and H4 receptor antagonists reduces inflammation in a mouse model of atopic dermatitis. J Dermatol Sci. 2017 Aug;87(2):130-137. doi: 10.1016/j.jdermsci.2017.04.004. Epub 2017 Apr 21. PubMed PMID: 28495120.

3: Thurmond RL, Venable J, Savall B, La D, Snook S, Dunford PJ, Edwards JP. Clinical Development of Histamine H(4) Receptor Antagonists. Handb Exp Pharmacol. 2017;241:301-320. doi: 10.1007/164_2016_130. Review. PubMed PMID: 28233185.

4: Sulaiman I, Lim JC, Soo HL, Stanslas J. Molecularly targeted therapies for asthma: Current development, challenges and potential clinical translation. Pulm Pharmacol Ther. 2016 Oct;40:52-68. doi: 10.1016/j.pupt.2016.07.005. Epub 2016 Jul 22. Review. PubMed PMID: 27453494.

5: Murata Y, Song M, Kikuchi H, Hisamichi K, Xu XL, Greenspan A, Kato M, Chiou CF, Kato T, Guzzo C, Thurmond RL, Ohtsuki M, Furue M. Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4 R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis. J Dermatol. 2015 Feb;42(2):129-39. doi: 10.1111/1346-8138.12726. Epub 2014 Dec 9. PubMed PMID: 25491792.

6: Seifert R. Therapeutic efficacy of a H₄ receptor antagonist in humans: a milestone in histamine research. J Pharmacol Exp Ther. 2014 Jul;350(1):2-4. doi: 10.1124/jpet.114.215749comm. PubMed PMID: 24925898.

7: Kollmeier A, Francke K, Chen B, Dunford PJ, Greenspan AJ, Xia Y, Xu XL, Zhou B, Thurmond RL. The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects. J Pharmacol Exp Ther. 2014 Jul;350(1):181-7. doi: 10.1124/jpet.114.215749. Epub 2014 May 9. PubMed PMID: 24817035.

8: Thurmond RL, Chen B, Dunford PJ, Greenspan AJ, Karlsson L, La D, Ward P, Xu XL. Clinical and preclinical characterization of the histamine H(4) receptor antagonist JNJ-39758979. J Pharmacol Exp Ther. 2014 May;349(2):176-84. doi: 10.1124/jpet.113.211714. Epub 2014 Feb 18. PubMed PMID: 24549371.

9: Savall BM, Chavez F, Tays K, Dunford PJ, Cowden JM, Hack MD, Wolin RL, Thurmond RL, Edwards JP. Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists. J Med Chem. 2014 Mar 27;57(6):2429-39. doi: 10.1021/jm401727m. Epub 2014 Feb 21. PubMed PMID: 24495018.