FAUC-213

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562796

CAS#: 337972-47-1

Description: FAUC-213 is a selective dopamine D4 receptor full antagonist.

Chemical Structure

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FAUC-213
CAS# 337972-47-1
Instruction

Theoretical Analysis

MedKoo Cat#: 562796
Name: FAUC-213
CAS#: 337972-47-1
Chemical Formula: C18H19ClN4
Exact Mass: 326.13
Molecular Weight: 326.820
Elemental Analysis: C, 66.15; H, 5.86; Cl, 10.85; N, 17.14

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: FAUC-213; FAUC 213; FAUC213;

IUPAC/Chemical Name: 2-[4-(4-Chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine

InChi Key: DTRXURJDKOYCCD-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)14-16-13-18-3-1-2-8-23(18)20-16/h1-8,13H,9-12,14H2

SMILES Code: ClC1=CC=C(N2CCN(CC3=NN4C=CC=CC4=C3)CC2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 326.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Stößel A, Brox R, Purkayastha N, Hübner H, Hocke C, Prante O, Gmeiner P. Development of molecular tools based on the dopamine D(3) receptor ligand FAUC 329 showing inhibiting effects on drug and food maintained behavior. Bioorg Med Chem. 2017 Jul 1;25(13):3491-3499. doi: 10.1016/j.bmc.2017.04.036. Epub 2017 Apr 29. PubMed PMID: 28495386; PubMed Central PMCID: PMC5512454.

2: Janhunen SK, la Fleur SE, Adan RA. Blocking alpha2A adrenoceptors, but not dopamine receptors, augments bupropion-induced hypophagia in rats. Obesity (Silver Spring). 2013 Dec;21(12):E700-8. doi: 10.1002/oby.20581. Epub 2013 Sep 5. PubMed PMID: 23894096.

3: Sanna F, Corda MG, Melis MR, Piludu MA, Löber S, Hübner H, Gmeiner P, Argiolas A, Giorgi O. Dopamine agonist-induced penile erection and yawning: a comparative study in outbred Roman high- and low-avoidance rats. Pharmacol Biochem Behav. 2013 Aug;109:59-66. doi: 10.1016/j.pbb.2013.05.002. Epub 2013 May 8. PubMed PMID: 23664901.

4: Prante O, Tietze R, Hocke C, Löber S, Hübner H, Kuwert T, Gmeiner P. Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. J Med Chem. 2008 Mar 27;51(6):1800-10. doi: 10.1021/jm701375u. Epub 2008 Feb 29. PubMed PMID: 18307287.

5: Floresca CZ, Chen S, Kortagere S, Schetz JA. Reciprocal mutations in TM2/TM3 in a D2 dopamine receptor background confirms the importance of this microdomain as a selective determinant of para-halogenated 1,4-disubstituted aromatic piperazines. Arch Pharm (Weinheim). 2005 Jun;338(5-6):268-75. PubMed PMID: 15952239.

6: Boeckler F, Russig H, Zhang W, Löber S, Schetz J, Hübner H, Ferger B, Gmeiner P, Feldon J. FAUC 213, a highly selective dopamine D4 receptor full antagonist, exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia. Psychopharmacology (Berl). 2004 Aug;175(1):7-17. Epub 2004 Mar 6. PubMed PMID: 15007532.

7: Boeckler F, Leng A, Mura A, Bettinetti L, Feldon J, Gmeiner P, Ferger B. Attenuation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity by the novel selective dopamine D3-receptor partial agonist FAUC 329 predominantly in the nucleus accumbens of mice. Biochem Pharmacol. 2003 Sep 15;66(6):1025-32. PubMed PMID: 12963489.

8: Löber S, Hübner H, Utz W, Gmeiner P. Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213). J Med Chem. 2001 Aug 16;44(17):2691-4. PubMed PMID: 11495580.