Vinylbital

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596200

CAS#: 2430-49-1

Description: Vinylbital, also known as butylvinal, is a sedative hypnotic drug which is a barbiturate derivative. It was developed by Aktieboleget Pharmacia in the 1950s. Vinylbital is discontinued.

Chemical Structure

img
Vinylbital
CAS# 2430-49-1
Instruction

Theoretical Analysis

MedKoo Cat#: 596200
Name: Vinylbital
CAS#: 2430-49-1
Chemical Formula: C11H16N2O3
Exact Mass: 224.12
Molecular Weight: 224.260
Elemental Analysis: C, 58.91; H, 7.19; N, 12.49; O, 21.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Vinylbital; JD-96; Bykonox; butylvinal; Speda; Vinylbitone;

IUPAC/Chemical Name: 5-(pentan-2-yl)-5-vinylpyrimidine-2,4,6(1H,3H,5H)-trione

InChi Key: KGKJZEKQJQQOTD-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H16N2O3/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h5,7H,2,4,6H2,1,3H3,(H2,12,13,14,15,16)

SMILES Code: O=C1NC(C(C(C)CCC)(C=C)C(N1)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 224.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Maurer HH. Identification and differentiation of barbiturates, other sedative-hypnotics and their metabolites in urine integrated in a general screening procedure using computerized gas chromatography-mass spectrometry. J Chromatogr. 1990 Sep 14;530(2):307-26. PubMed PMID: 2079506.

2: De Groot G, Maes RA, Van Heijst AN. A toxicological evaluation of different adsorbents in hemoperfusion. Clin Toxicol. 1981 Oct;18(10):1199-211. PubMed PMID: 6122529.

3: Vermeulen NP, Bakker BH, Eylers D, Breimer DD. The epoxide-diol pathway in the metabolism of vinylbital in rat and man. Xenobiotica. 1980 Mar;10(3):159-68. PubMed PMID: 6110286.

4: Preuss FR, Gutzler H. [Studies on the biotransformation of 5-vinyl-5-(1-methylbutyl)- and 5-vinyl-5-(1-ethyl-propyl)-barbituric acid (author's transl)]. Arzneimittelforschung. 1976;26(11):2080-4. German. PubMed PMID: 1037252.

5: Breimer DD, de Boer AG. Pharmacokinetics and relative bioavailability of vinylbital in man after oral and rectal administration. Arzneimittelforschung. 1976;26(3):448-54. PubMed PMID: 989344.

6: Geldmacher-von Mallinck, Egger B. [Metabolism of 5-vinyl-5-(1'-methylbutyl)-barbituric acid (vinylbital) in man. 3. Metabolism and excretion of (-)-vinylbital]. Arzneimittelforschung. 1971 Aug;21(8):1272-4. German. PubMed PMID: 5110033.

7: Geldmacher-von Mallinck, Egger B, Fröhlich F. [Metabolism of 5-vinyl-5-(1'-methylbutyl)-barbituric acid (Vinylbital) in human. 2. Course of metabolite elimination of racemic vinylbital in urine]. Arzneimittelforschung. 1971 Jul;21(7):939-41. German. PubMed PMID: 5109505.

8: Knabe J, Geismar W. [Barbituric acid derivatives. 4. Relative configuration of opt. active pentobarbital, vinylbital and thiopental]. Arch Pharm Ber Dtsch Pharm Ges. 1968 Sep;301(9):682-5. German. PubMed PMID: 5250001.

9: Preuss FR, Müller D. [Studies on the biotransformation of 5-(1'-methyl-n-butyl)-5-vinylbarbituric acid (Vinylbital). 3. Isolation and identification of a renal excretion product and synthesis of some comparative substances]. Arzneimittelforschung. 1968 Jun;18(6):714-8. German. PubMed PMID: 5755809.

10: Preuss FR, Müller D. [Studies on the biotransformation of 5-(1'-methyl-n-butyl)-5-vinylbarbituric acid (Vinylbital). 2. Synthesis of some substances as possible degradatuon producrs of Vinylbital]. Arzneimittelforschung. 1968 May;18(5):606-10. German. PubMed PMID: 5755893.

11: Jovanović UJ. [Neurophysiologic interpretation of the mechanism of action of vinylbital]. Arzneimittelforschung. 1967 Nov;17(11):1369-74. Review. German. PubMed PMID: 4876966.