JB 1-0

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596195

CAS#: 78617-10-4

Description: JB 1-0 is a bioactive chemical.

Chemical Structure

JB 1-0
CAS# 78617-10-4

Theoretical Analysis

MedKoo Cat#: 596195
Name: JB 1-0
CAS#: 78617-10-4
Chemical Formula: C17H22BrNO3
Exact Mass: 367.0783
Molecular Weight: 368.27
Elemental Analysis: C, 55.44; H, 6.02; Br, 21.70; N, 3.80; O, 13.03

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JB 1-0;

IUPAC/Chemical Name: 4-(2-bromo-4,5-dimethoxyphenyl)octahydro-2H-quinolizin-2-one


InChi Code: InChI=1S/C17H22BrNO3/c1-21-16-9-13(14(18)10-17(16)22-2)15-8-12(20)7-11-5-3-4-6-19(11)15/h9-11,15H,3-8H2,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 368.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Gao QG, Xie JX, Wong MS, Chen WF. IGF-I receptor signaling pathway is involved in the neuroprotective effect of genistein in the neuroblastoma SK-N-SH cells. Eur J Pharmacol. 2012 Feb 29;677(1-3):39-46. doi: 10.1016/j.ejphar.2011.12.032. Epub 2011 Dec 29. PubMed PMID: 22227334.

2: Rainsford KD. Effects of anti-inflammatory drugs and agents that modify intracellular transduction signals or metabolic activities in inflammatory cells on interleukin-1 induced cartilage proteoglycan resorption in vitro. Pharmacol Res. 1992 May-Jun;25(4):335-46. PubMed PMID: 1329061.

3: Lema WJ, Blankenship JW, Malone MH. Prostaglandin synthetase inhibition by alkaloids of Heimia salicifolia. J Ethnopharmacol. 1986 Feb;15(2):161-7. PubMed PMID: 3086627.

4: Byrne JA, Malone MH, Quick J, Meltzer PC. Evaluation of four homologs of 4-(2-bromo-4,5-dimethoxyphenyl)-octahydro-2H-quinolizin-2-one (JB-1-0) for their capacity to prevent carrageenan induced pedal edema in the rat. Proc West Pharmacol Soc. 1984;27:293-6. PubMed PMID: 6494167.

5: Malone MH, Quick J, Meltzer PC. Relative protective effects of 20 homologs of 4-(2-bromo-4,5-dimethoxyphenyl)-octahydro-2H-quinolizin-2-one (JB-1-0) against croton oil induced inflammation in mice. Proc West Pharmacol Soc. 1983;26:351-5. PubMed PMID: 6889363.