VU0415374

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MedKoo CAT#: 562787

CAS#: 1266338-03-7

Description: VU0415374 is a mGlu4 positive allosteric modulator (PAM).


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-29. Prices are subject to change without notice.

VU0415374 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562787
Name: VU0415374
CAS#: 1266338-03-7
Chemical Formula: C20H16ClN3O3
Exact Mass: 381.088
Molecular Weight: 381.81
Elemental Analysis: C, 62.92; H, 4.22; Cl, 9.28; N, 11.01; O, 12.57


Synonym: VU0415374; VU-0415374; VU 0415374;

IUPAC/Chemical Name: N-(4-(2-Chlorobenzamido)-3-methoxyphenyl)picolinamide

InChi Key: RZZCVJKQCRSTKD-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H16ClN3O3/c1-27-18-12-13(23-20(26)17-8-4-5-11-22-17)9-10-16(18)24-19(25)14-6-2-3-7-15(14)21/h2-12H,1H3,(H,23,26)(H,24,25)

SMILES Code: O=C(NC1=CC=C(NC(C2=CC=CC=C2Cl)=O)C(OC)=C1)C3=NC=CC=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Rovira X, Malhaire F, Scholler P, Rodrigo J, Gonzalez-Bulnes P, Llebaria A, Pin JP, Giraldo J, Goudet C. Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors. FASEB J. 2015 Jan;29(1):116-30. doi: 10.1096/fj.14-257287. Epub 2014 Oct 23. PubMed PMID: 25342125.