Jatropholone A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596173

CAS#: 71424-66-3

Description: Jatropholone A is a diterpene derivative of jarophone.

Chemical Structure

Jatropholone A
CAS# 71424-66-3

Theoretical Analysis

MedKoo Cat#: 596173
Name: Jatropholone A
CAS#: 71424-66-3
Chemical Formula: C20H24O2
Exact Mass: 296.1776
Molecular Weight: 296.41
Elemental Analysis: C, 81.04; H, 8.16; O, 10.80

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Jatropholone A; CCRIS 1441; CCRIS-1441; CCRIS1441;

IUPAC/Chemical Name: (5S,9aS)-3-hydroxy-1,1,2,5-tetramethyl-7-methylene-1,4,5,6a,7,8,9,9a-octahydro-6H-cyclopropa[3,4]cyclohepta[1,2-e]inden-6-one


InChi Code: InChI=1S/C20H24O2/c1-9-8-13-12(15-10(2)16(15)18(9)21)6-7-14-17(13)19(22)11(3)20(14,4)5/h9,14,16,22H,2,6-8H2,1,3-5H3/t9-,14+,16?/m0/s1

SMILES Code: O=C([C@@H](C)C1)C2C(C2=C)=C3C1=C4C(O)=C(C)C(C)(C)[C@]4([H])CC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 296.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Theoduloz C, Rodríguez JA, Pertino M, Schmeda-Hirschmann G. Antiproliferative activity of the diterpenes jatrophone and jatropholone and their derivatives. Planta Med. 2009 Nov;75(14):1520-2. doi: 10.1055/s-0029-1185834. Epub 2009 Jun 26. PubMed PMID: 19562659.

2: Pertino M, Schmeda-Hirschmann G, Rodríguez JA, Theoduloz C. Gastroprotective effect and cytotoxicity of semisynthetic jatropholone derivatives. Planta Med. 2007 Aug;73(10):1095-100. Epub 2007 Aug 9. PubMed PMID: 17691058.

3: Pertino M, Schmeda-Hirschmann G, Rodríguez JA, Theoduloz C. Gastroprotective effect and cytotoxicity of terpenes from the Paraguayan crude drug "yagua rova" (Jatropha isabelli). J Ethnopharmacol. 2007 May 22;111(3):553-9. Epub 2007 Jan 7. PubMed PMID: 17276635.