WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591096

CAS#: 77-86-1

Description: Tromethamine is an organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer.

Chemical Structure

CAS# 77-86-1

Theoretical Analysis

MedKoo Cat#: 591096
Name: Tromethamine
CAS#: 77-86-1
Chemical Formula: C4H11NO3
Exact Mass: 121.07
Molecular Weight: 121.140
Elemental Analysis: C, 39.66; H, 9.15; N, 11.56; O, 39.62

Price and Availability

Size Price Availability Quantity
500g USD 260
1kg USD 420
5kg USD 1000
Bulk inquiry

Synonym: Tromethamine; NSC 6365; NSC-6365; NSC6365;

IUPAC/Chemical Name: 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-


InChi Code: InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 121.140000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Gill LJ, Heldreth B. Safety Assessment of Tromethamine, Aminomethyl Propanediol, and Aminoethyl Propanediol as Used in Cosmetics. Int J Toxicol. 2018 May/Jun;37(1_suppl):5S-18S. doi: 10.1177/1091581817738242. PubMed PMID: 29761730. 2: Çağlayan M, Kösekahya P, Gürdal C, Saraç Ö. Comparison of Electrocoagulation and Conventional Medical Drops for Treatment of Conjunctivochalasis: Short-Term Results. Turk J Ophthalmol. 2018 Apr;48(2):61-65. doi: 10.4274/tjo.35002. Epub 2018 Apr 25. PubMed PMID: 29755817; PubMed Central PMCID: PMC5938477. 3: Nguyen BN, Barta RJ, Stewart C, Heinrich CA. "Toradol® following breast surgery: Is there an increased risk of hematoma?" Plast Reconstr Surg. 2018 Mar 15. doi: 10.1097/PRS.0000000000004361. [Epub ahead of print] PubMed PMID: 29750761. 4: Gallo G, Mistrangelo M, Passera R, Testa V, Pozzo M, Perinotti R, Lanati I, Lazzari I, Tonello P, Ugliono E, De Luca E, Realis Luc A, Clerico G, Trompetto M. Efficacy of Mesoglycan in Pain Control after Excisional Hemorrhoidectomy: A Pilot Comparative Prospective Multicenter Study. Gastroenterol Res Pract. 2018 Mar 19;2018:6423895. doi: 10.1155/2018/6423895. eCollection 2018. PubMed PMID: 29743886; PubMed Central PMCID: PMC5884030. 5: Fan L, Shang X, Zhu J, Ma B, Zhang Q. Pharmacodynamic and pharmacokinetic studies and prostatic tissue distribution of fosfomycin tromethamine in bacterial prostatitis or normal rats. Andrologia. 2018 May 2:e13021. doi: 10.1111/and.13021. [Epub ahead of print] PubMed PMID: 29718594. 6: Gurunathan U, Parker SL, Maguire R, Ramdath D, Bijoor M, Wallis SC, Roberts JA. Population Pharmacokinetics of Periarticular Ketorolac in Adult Patients Undergoing Total Hip or Total Knee Replacement Surgery. Anesth Analg. 2018 Apr 23. doi: 10.1213/ANE.0000000000003377. [Epub ahead of print] PubMed PMID: 29697507. 7: Alnagdy AA, Abouelkheir HY, El-Khouly SE, Tarshouby SM. Impact of topical nonsteroidal anti-inflammatory drugs in prevention of macular edema following cataract surgery in diabetic patients. Int J Ophthalmol. 2018 Apr 18;11(4):616-622. doi: 10.18240/ijo.2018.04.13. eCollection 2018. PubMed PMID: 29675380; PubMed Central PMCID: PMC5902366. 8: Zhanel GG, Zhanel MA, Karlowsky JA. Oral Fosfomycin for the Treatment of Acute and Chronic Bacterial Prostatitis Caused by Multidrug-Resistant Escherichia coli. Can J Infect Dis Med Microbiol. 2018 Jan 30;2018:1404813. doi: 10.1155/2018/1404813. eCollection 2018. Review. PubMed PMID: 29666664; PubMed Central PMCID: PMC5831921. 9: Stock RA, Galvan DK, Godoy R, Bonamigo EL. Comparison of macular thickness by optical coherence tomography measurements after uneventful phacoemulsification using ketorolac tromethamine, nepafenac, vs a control group, preoperatively and postoperatively. Clin Ophthalmol. 2018 Mar 29;12:607-611. doi: 10.2147/OPTH.S157738. eCollection 2018. PubMed PMID: 29636596; PubMed Central PMCID: PMC5880183. 10: Mikhaylov Y, Weinstein B, Schrank TP, Swartz JD, Ulm JP, Armstrong MB, Delaney KO. Ketorolac and Hematoma Incidence in Postmastectomy Implant-Based Breast Reconstruction. Ann Plast Surg. 2018 May;80(5):472-474. doi: 10.1097/SAP.0000000000001409. PubMed PMID: 29538000. 11: Dersch-Mills D, Alshaikh B, Soraisham AS, Akierman A, Yusuf K. Effectiveness of Injectable Ibuprofen Salts and Indomethacin to Treat Patent Ductus Arteriosus in Preterm Infants: Observational Cohort Study. Can J Hosp Pharm. 2018 Jan-Feb;71(1):22-28. Epub 2018 Mar 7. PubMed PMID: 29531394; PubMed Central PMCID: PMC5842047. 12: Orasugh JT, Saha NR, Sarkar G, Rana D, Mishra R, Mondal D, Ghosh SK, Chattopadhyay D. Synthesis of methylcellulose/cellulose nano-crystals nanocomposites: Material properties and study of sustained release of ketorolac tromethamine. Carbohydr Polym. 2018 May 15;188:168-180. doi: 10.1016/j.carbpol.2018.01.108. Epub 2018 Feb 4. PubMed PMID: 29525153. 13: Khan MA, Philip LM, Cheung G, Vadakepeedika S, Grasemann H, Sweezey N, Palaniyar N. Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis. Front Med (Lausanne). 2018 Feb 13;5:19. doi: 10.3389/fmed.2018.00019. eCollection 2018. PubMed PMID: 29487850; PubMed Central PMCID: PMC5816902. 14: Silva Filho SF, Pereira AC, Sarraguça JMG, Sarraguça MC, Lopes J, Façanha Filho PF, Dos Santos AO, da Silva Ribeiro PR. Synthesis of a Glibenclamide Cocrystal: Full Spectroscopic and Thermal Characterization. J Pharm Sci. 2018 Feb 9. pii: S0022-3549(18)30078-9. doi: 10.1016/j.xphs.2018.01.029. [Epub ahead of print] PubMed PMID: 29432762. 15: Ramírez AA, Villalvazo VMM, Arredondo ES, Ramírez HAR, Sevilla HM. D-Cloprostenol enhances estrus synchronization in tropical hair sheep. Trop Anim Health Prod. 2018 Jun;50(5):991-996. doi: 10.1007/s11250-018-1522-x. Epub 2018 Feb 10. PubMed PMID: 29429114. 16: Ortiz Zacarías NV, Dijkmans AC, Burggraaf J, Mouton JW, Wilms EB, van Nieuwkoop C, Touw DJ, Kamerling IMC, Stevens J. Fosfomycin as a potential therapy for the treatment of systemic infections: a population pharmacokinetic model to simulate multiple dosing regimens. Pharmacol Res Perspect. 2018 Feb;6(1). doi: 10.1002/prp2.378. PubMed PMID: 29417760; PubMed Central PMCID: PMC5803932. 17: Jin J, Hwang K, Joo JD, Han JH, Kim CY. Combination therapy of 7-O-succinyl macrolactin A tromethamine salt and temozolomide against experimental glioblastoma. Oncotarget. 2017 Dec 14;9(2):2140-2147. doi: 10.18632/oncotarget.23295. eCollection 2018 Jan 5. PubMed PMID: 29416760; PubMed Central PMCID: PMC5788628. 18: Jung Y, Hwang HS, Na K. Galactosylated iodine-based small molecule I.V. CT contrast agent for bile duct imaging. Biomaterials. 2018 Apr;160:15-23. doi: 10.1016/j.biomaterials.2018.01.017. Epub 2018 Jan 12. PubMed PMID: 29353104. 19: Carver TJ, Schrock JB, Kraeutler MJ, McCarty EC. The Evolving Treatment Patterns of NCAA Division I Football Players by Orthopaedic Team Physicians Over the Past Decade, 2008-2016. Sports Health. 2018 May/Jun;10(3):234-243. doi: 10.1177/1941738117745488. Epub 2018 Jan 3. PubMed PMID: 29298161. 20: Qiao LD, Chen S, Lin YH, Li JX, Hu WG, Hou JP, Cui L. Evaluation of perioperative prophylaxis with fosfomycin tromethamine in ureteroscopic stone removal: an investigator-driven prospective, multicenter, randomized, controlled study. Int Urol Nephrol. 2018 Mar;50(3):427-432. doi: 10.1007/s11255-017-1776-7. Epub 2017 Dec 30. PubMed PMID: 29290000; PubMed Central PMCID: PMC5845073.