Malachite green
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591088

CAS#: 569-64-2

Description: Malachite green is an organic compound that is used as a dyestuff and controversially as an antimicrobial in aquaculture.

Chemical Structure

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Malachite green
CAS# 569-64-2
Instruction

Theoretical Analysis

MedKoo Cat#: 591088
Name: Malachite green
CAS#: 569-64-2
Chemical Formula: C23H25ClN2
Exact Mass: 364.17
Molecular Weight: 364.920
Elemental Analysis: C, 75.70; H, 6.91; Cl, 9.71; N, 7.68

Price and Availability

Size Price Availability Quantity
5g USD 350 2 weeks
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Synonym: Solid Green Crystals O; Solid Green O; Malachite green;

IUPAC/Chemical Name: Ammonium, (4-(p-(dimethylamino)-alpha-phenylbenzylidene)-2,5-cyclohexadien-1-ylidene)-dimethyl-, chloride

InChi Key: FDZZZRQASAIRJF-UHFFFAOYSA-M

InChi Code: InChI=1S/C23H25N2.ClH/c1-24(2)21-14-10-19(11-15-21)23(18-8-6-5-7-9-18)20-12-16-22(17-13-20)25(3)4;/h5-17H,1-4H3;1H/q+1;/p-1

SMILES Code: C/[N+](C)=C1C=C/C(C=C/1)=C(C2=CC=CC=C2)/C3=CC=C(N(C)C)C=C3.[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 364.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhou Z, Fu Y, Qin Q, Lu X, Shi X, Zhao C, Xu G. Synthesis of magnetic mesoporous Fe(3)O(4)@PEI-MOF-5 for the effective enrichment of malachite green and crystal violet in fish samples. J Chromatogr A. 2018 May 9. pii: S0021-9673(18)30588-0. doi: 10.1016/j.chroma.2018.05.016. [Epub ahead of print] PubMed PMID: 29759648.

2: Zhou X, Zhang J, Pan Z, Li D. Review of Methods for the Detection and Determination of Malachite Green and Leuco-Malachite Green in Aquaculture. Crit Rev Anal Chem. 2018 May 14:1-20. doi: 10.1080/10408347.2018.1456314. [Epub ahead of print] PubMed PMID: 29757675.

3: Chahar M, Anvikar A, Dixit R, Valecha N. Evaluation of four novel isothermal amplification assays towards simple and rapid genotyping of chloroquine resistant Plasmodium falciparum. Exp Parasitol. 2018 May 8;190:1-9. doi: 10.1016/j.exppara.2018.05.001. [Epub ahead of print] PubMed PMID: 29750967.

4: Uda RM, Yoshikawa Y, Kitaba M, Nishimoto N. Irradiation-induced fusion between giant vesicles and photoresponsive large unilamellar vesicles containing malachite green derivative. Colloids Surf B Biointerfaces. 2018 May 1;167:544-549. doi: 10.1016/j.colsurfb.2018.04.061. [Epub ahead of print] PubMed PMID: 29730576.

5: Świderska-Dąbrowska R, Piaskowski K, Zarzycki PK. Preliminary Studies of Synthetic Dye Adsorption on Iron Sludge and Activated Carbons. J AOAC Int. 2018 May 3. doi: 10.5740/jaoacint.18-0060. [Epub ahead of print] PubMed PMID: 29724261.

6: Bamal HD, Chen W, Mashele SS, Nelson DR, Kappo AP, Mosa RA, Yu JH, Tuszynski JA, Syed K. Comparative analyses and structural insights of the novel cytochrome P450 fusion protein family CYP5619 in Oomycetes. Sci Rep. 2018 Apr 26;8(1):6597. doi: 10.1038/s41598-018-25044-0. PubMed PMID: 29700357; PubMed Central PMCID: PMC5919972.

7: Li WL, Kong FZ, Zhang Q, Liu WW, Kong H, Liu XP, Khan MI, Wahid A, Saud S, Xiao H, Cao CX, Fan LY. A simple chip electrophoresis titration of neutralization boundary with EDTA photo-catalysis for distance-based sensing of melamine in dairy products. Anal Chem. 2018 Apr 26. doi: 10.1021/acs.analchem.8b00543. [Epub ahead of print] PubMed PMID: 29696971.

8: Selvasembian R, P B. Utilization of unconventional lignocellulosic waste biomass for the biosorption of toxic triphenylmethane dye malachite green from aqueous solution. Int J Phytoremediation. 2018 May 12;20(6):624-633. doi: 10.1080/15226514.2017.1413329. PubMed PMID: 29688057.

9: Takahashi K, Sakai K, Fukasawa W, Nagano Y, Sakaguchi SO, Lima AO, Pellizari VH, Iwatsuki M, Takishita K, Yoshida T, Nonaka K, Fujikura K, Ōmura S. Quellenin, a new anti-Saprolegnia compound isolated from the deep-sea fungus, Aspergillus sp. YK-76. J Antibiot (Tokyo). 2018 Apr 23. doi: 10.1038/s41429-018-0053-z. [Epub ahead of print] PubMed PMID: 29686353.

10: Liang Q, Cui S, Liu C, Xu S, Yao C, Li Z. Construction of CdS@UIO-66-NH(2) core-shell nanorods for enhanced photocatalytic activity with excellent photostability. J Colloid Interface Sci. 2018 Apr 2;524:379-387. doi: 10.1016/j.jcis.2018.03.114. [Epub ahead of print] PubMed PMID: 29660625.

11: Pandey RK, Tewari S, Tewari L. Lignolytic mushroom Lenzites elegans WDP2: Laccase production, characterization, and bioremediation of synthetic dyes. Ecotoxicol Environ Saf. 2018 Apr 12;158:50-58. doi: 10.1016/j.ecoenv.2018.04.003. [Epub ahead of print] PubMed PMID: 29656164.

12: Hua Y, Xiao J, Zhang Q, Cui C, Wang C. Facile synthesis of surface-functionalized magnetic nanocomposites for effectively selective adsorption of cationic dyes. Nanoscale Res Lett. 2018 Apr 12;13(1):99. doi: 10.1186/s11671-018-2476-7. PubMed PMID: 29651623; PubMed Central PMCID: PMC5897273.

13: Camargo VDS, Santana BN, Ferrari ED, Nakamura AA, Nagata WB, Nardi ARM, Meireles MV. Detection and molecular characterization of Cryptosporidium spp. in captive canaries (Serinus canaria) using different diagnostic methods. Rev Bras Parasitol Vet. 2018 Jan-Mar;27(1):61-66. doi: 10.1590/S1984-296120180010. Epub 2018 Mar 1. PubMed PMID: 29641795.

14: Yu M, Han Y, Li J, Wang L. Magnetic N-doped carbon aerogel from sodium carboxymethyl cellulose/collagen composite aerogel for dye adsorption and electrochemical supercapacitor. Int J Biol Macromol. 2018 Apr 6;115:185-193. doi: 10.1016/j.ijbiomac.2018.04.012. [Epub ahead of print] PubMed PMID: 29627469.

15: Rawat AP, Singh DP. Decolourization of malachite green dye by mentha plant biochar (MPB): a combined action of adsorption and electrochemical reduction processes. Water Sci Technol. 2018 Mar;77(6):1734-1743. doi: 10.2166/wst.2018.059. PubMed PMID: 29595176; PubMed Central PMCID: wst_2018_059.

16: Nagai T. A novel, efficient, and ecologically relevant bioassay method using aquatic fungi and fungus-like organisms for fungicide ecological effect assessment. Environ Toxicol Chem. 2018 Mar 23. doi: 10.1002/etc.4138. [Epub ahead of print] PubMed PMID: 29572919.

17: Zhang X, Wang M, Lin L, Xiao G, Tang Z, Zhu X. Synthesis of novel laccase-biotitania biocatalysts for malachite green decolorization. J Biosci Bioeng. 2018 Mar 19. pii: S1389-1723(17)30930-1. doi: 10.1016/j.jbiosc.2018.01.021. [Epub ahead of print] PubMed PMID: 29567373.

18: Schwarz-Schilling M, Dupin A, Chizzolini F, Krishnan S, Mansy SS, Simmel FC. Optimized Assembly of a Multifunctional RNA-Protein Nanostructure in a Cell-Free Gene Expression System. Nano Lett. 2018 Apr 11;18(4):2650-2657. doi: 10.1021/acs.nanolett.8b00526. Epub 2018 Mar 27. PubMed PMID: 29564885.

19: Yang Q, Wang Y, Wang J, Liu F, Hu N, Pei H, Yang W, Li Z, Suo Y, Wang J. High effective adsorption/removal of illegal food dyes from contaminated aqueous solution by Zr-MOFs (UiO-67). Food Chem. 2018 Jul 15;254:241-248. doi: 10.1016/j.foodchem.2018.02.011. Epub 2018 Feb 3. PubMed PMID: 29548448.

20: Li Z, Jiang S, Huo Y, Ning T, Liu A, Zhang C, He Y, Wang M, Li C, Man B. 3D silver nanoparticles with multilayer graphene oxide as a spacer for surface enhanced Raman spectroscopy analysis. Nanoscale. 2018 Mar 29;10(13):5897-5905. doi: 10.1039/C7NR09276H. PubMed PMID: 29546897.