WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591064

CAS#: 153719-23-4

Description: Thiamethoxam is a systemic insecticide in the class of neonicotinoids. It has a broad spectrum of activity against many types of insects.

Chemical Structure

CAS# 153719-23-4

Theoretical Analysis

MedKoo Cat#: 591064
Name: Thiamethoxam
CAS#: 153719-23-4
Chemical Formula: C8H10ClN5O3S
Exact Mass: 291.02
Molecular Weight: 291.710
Elemental Analysis: C, 32.94; H, 3.46; Cl, 12.15; N, 24.01; O, 16.45; S, 10.99

Price and Availability

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100mg USD 250
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Synonym: Adage; Adage 5FS

IUPAC/Chemical Name: 3-(2-Chloro-thiazol-5-ylmethyl)-5-methyl(1,3,5)oxadiazinan-4-ylidene-N-nitroamine


InChi Code: InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3/b11-8+

SMILES Code: O=[N+](/N=C1N(CC2=CN=C(Cl)S2)COCN/1C)[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 291.710000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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[Epub ahead of print] PubMed PMID: 29735281. 4: Focks A, Belgers D, Boerwinkel MC, Buijse L, Roessink I, Van den Brink PJ. Calibration and validation of toxicokinetic-toxicodynamic models for three neonicotinoids and some aquatic macroinvertebrates. Ecotoxicology. 2018 May 1. doi: 10.1007/s10646-018-1940-6. [Epub ahead of print] PubMed PMID: 29717389. 5: Marina CF, Bond JG, Muñoz J, Valle J, Quiroz-Martínez H, Torres-Monzón JA, Williams T. Efficacy of larvicides for the control of dengue, Zika, and chikungunya vectors in an urban cemetery in southern Mexico. Parasitol Res. 2018 Jun;117(6):1941-1952. doi: 10.1007/s00436-018-5891-x. Epub 2018 Apr 30. PubMed PMID: 29713901. 6: Challis JK, Cuscito LD, Joudan S, Luong KH, Knapp CW, Hanson ML, Wong CS. Inputs, source apportionment, and transboundary transport of pesticides and other polar organic contaminants along the lower Red River, Manitoba, Canada. Sci Total Environ. 2018 Apr 20;635:803-816. doi: 10.1016/j.scitotenv.2018.04.128. [Epub ahead of print] PubMed PMID: 29710604. 7: Baldissera MD, Souza CF, Seben D, Sippert LR, Salbego J, Marchesan E, Zanella R, Baldisserotto B, Golombieski JI. Gill bioenergetics dysfunction and oxidative damage induced by thiamethoxam exposure as relevant toxicological mechanisms in freshwater silver catfish Rhamdia quelen. Sci Total Environ. 2018 Apr 27;636:420-426. doi: 10.1016/j.scitotenv.2018.04.292. [Epub ahead of print] PubMed PMID: 29709859. 8: MacDonald AM, Jardine CM, Thomas PJ, Nemeth NM. Neonicotinoid detection in wild turkeys (Meleagris gallopavo silvestris) in Ontario, Canada. Environ Sci Pollut Res Int. 2018 Apr 27. doi: 10.1007/s11356-018-2093-0. [Epub ahead of print] PubMed PMID: 29704179. 9: Langdon KW, Schumann R, Stelinski LL, Rogers ME. Spatial and Temporal Distribution of Soil-Applied Neonicotinoids in Citrus Tree Foliage. J Econ Entomol. 2018 Apr 23. doi: 10.1093/jee/toy114. [Epub ahead of print] PubMed PMID: 29688422. 10: Suganthi A, Nikita SA, Kousika J, Bhuvaneswari K, Sridharan S. Determination of thiamethoxam residues in banana stem and fruit through LC-MS/MS. Environ Monit Assess. 2018 Apr 18;190(5):293. doi: 10.1007/s10661-018-6655-x. PubMed PMID: 29671070. 11: Pan Y, Tian F, Wei X, Wu Y, Gao X, Xi J, Shang Q. Thiamethoxam Resistance in Aphis gossypii Glover Relies on Multiple UDP-Glucuronosyltransferases. Front Physiol. 2018 Apr 3;9:322. doi: 10.3389/fphys.2018.00322. eCollection 2018. PubMed PMID: 29670540; PubMed Central PMCID: PMC5893893. 12: Moyakao K, Santaladchaiyakit Y, Srijaranai S, Vichapong J. Preconcentration of Trace Neonicotinoid Insecticide Residues Using Vortex-Assisted Dispersive Micro Solid-Phase Extraction with Montmorillonite as an Efficient Sorbent. Molecules. 2018 Apr 11;23(4). pii: E883. doi: 10.3390/molecules23040883. PubMed PMID: 29641473. 13: Baldissera MD, Souza CF, Golombieski JI, Seben D, Sippert LR, Salbego J, Zanella R, Baldisserotto B. Thiamethoxam induced hepatic energy changes in silver catfish via impairment of the phosphoryl transfer network pathway: Toxicological effects on energetics homeostasis. Environ Toxicol Pharmacol. 2018 Apr 3;60:1-4. doi: 10.1016/j.etap.2018.04.002. [Epub ahead of print] PubMed PMID: 29631152. 14: de Lima E Silva C, Mariette J, Verweij RA, van Gestel CAM. Assessing the toxicity of thiamethoxam, in natural LUFA 2.2 soil, through three generations of Folsomia candida. Ecotoxicology. 2018 Apr 3. doi: 10.1007/s10646-018-1922-8. [Epub ahead of print] PubMed PMID: 29616379. 15: Hernando MD, Gámiz V, Gil-Lebrero S, Rodríguez I, García-Valcárcel AI, Cutillas V, Fernández-Alba AR, Flores JM. Viability of honeybee colonies exposed to sunflowers grown from seeds treated with the neonicotinoids thiamethoxam and clothianidin. Chemosphere. 2018 Jul;202:609-617. doi: 10.1016/j.chemosphere.2018.03.115. Epub 2018 Mar 19. PubMed PMID: 29597178. 16: Şenyildiz M, Kilinc A, Ozden S. Investigation of the genotoxic and cytotoxic effects of widely used neonicotinoid insecticides in HepG2 and SH-SY5Y cells. Toxicol Ind Health. 2018 Jun;34(6):375-383. doi: 10.1177/0748233718762609. Epub 2018 Mar 28. PubMed PMID: 29591886. 17: Sultana T, Murray C, Kleywegt S, Metcalfe CD. Neonicotinoid pesticides in drinking water in agricultural regions of southern Ontario, Canada. Chemosphere. 2018 Jul;202:506-513. doi: 10.1016/j.chemosphere.2018.02.108. Epub 2018 Mar 21. PubMed PMID: 29587231. 18: Manjon C, Troczka BJ, Zaworra M, Beadle K, Randall E, Hertlein G, Singh KS, Zimmer CT, Homem RA, Lueke B, Reid R, Kor L, Kohler M, Benting J, Williamson MS, Davies TGE, Field LM, Bass C, Nauen R. Unravelling the Molecular Determinants of Bee Sensitivity to Neonicotinoid Insecticides. Curr Biol. 2018 Apr 2;28(7):1137-1143.e5. doi: 10.1016/j.cub.2018.02.045. Epub 2018 Mar 22. PubMed PMID: 29576476; PubMed Central PMCID: PMC5887109. 19: Maloney EM, Morrissey CA, Headley JV, Peru KM, Liber K. Can chronic exposure to imidacloprid, clothianidin, and thiamethoxam mixtures exert greater than additive toxicity in Chironomus dilutus? Ecotoxicol Environ Saf. 2018 Jul 30;156:354-365. doi: 10.1016/j.ecoenv.2018.03.003. Epub 2018 Mar 21. PubMed PMID: 29573726. 20: Kumar N, Narayanan N, Gupta S. Application of magnetic molecularly imprinted polymers for extraction of imidacloprid from eggplant and honey. Food Chem. 2018 Jul 30;255:81-88. doi: 10.1016/j.foodchem.2018.02.061. Epub 2018 Feb 12. PubMed PMID: 29571502.