BCTP

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562732

CAS#: 464152-46-3

Description: BCTP is a polymodal inhibitor of TRPV1 with a reduced liability for hyperthermia.


Price and Availability

Size
Price

Size
Price

Size
Price

BCTP is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 562732
Name: BCTP
CAS#: 464152-46-3
Chemical Formula: C17H16ClN3OS
Exact Mass: 345.0703
Molecular Weight: 345.84
Elemental Analysis: C, 59.04; H, 4.66; Cl, 10.25; N, 12.15; O, 4.63; S, 9.27


Synonym: BCTP;

IUPAC/Chemical Name: 7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one

InChi Key: BOBBYBHJYYJHHQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H16ClN3OS/c1-17(2,3)13-11(9-4-6-10(18)7-5-9)8-12-14(19-13)20-16(23)21-15(12)22/h4-8H,1-3H3,(H2,19,20,21,22,23)

SMILES Code: O=C(N1)C2=CC(C3=CC=C(Cl)C=C3)=C(C(C)(C)C)N=C2NC1=S


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Nash MS, McIntyre P, Groarke A, Lilley E, Culshaw A, Hallett A, Panesar M, Fox A, Bevan S. 7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4 -one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hypersensitivity. J Pharmacol Exp Ther. 2012 Aug;342(2):389-98. doi: 10.1124/jpet.112.191932. Epub 2012 May 7. PubMed PMID: 22566669.

2: Wang YH, Fu R, Shao ZH, Wang HQ, Xing LM, Liu H, Wu YH, Li LJ, Liu H, Wang J, Chen J, Wang HL. [Study on quantity and function of bone marrow macrophages in patients with BMMNC-Coombs Test(+) pancytopenia]. Zhonghua Xue Ye Xue Za Zhi. 2009 Aug;30(8):538-42. Chinese. PubMed PMID: 19954642.

3: Teixeira PC, Leite GM, Domingues RJ, Silva J, Gibbs PA, Ferreira JP. Antimicrobial effects of a microemulsion and a nanoemulsion on enteric and other pathogens and biofilms. Int J Food Microbiol. 2007 Aug 15;118(1):15-9. Epub 2007 Jun 12. PubMed PMID: 17610974.

4: Hamouda T, Hayes MM, Cao Z, Tonda R, Johnson K, Wright DC, Brisker J, Baker JR Jr. A novel surfactant nanoemulsion with broad-spectrum sporicidal activity against Bacillus species. J Infect Dis. 1999 Dec;180(6):1939-49. PubMed PMID: 10558951.

5: BCTP sounds its battle cry. Environ Health Perspect. 1999 Feb;107(2):A64-5. PubMed PMID: 10348630; PubMed Central PMCID: PMC1566347.

6: Koronakis V, Hughes C, Koronakis E. ATPase activity and ATP/ADP-induced conformational change in the soluble domain of the bacterial protein translocator HlyB. Mol Microbiol. 1993 Jun;8(6):1163-75. PubMed PMID: 8361361.