BCTP

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562732

CAS#: 464152-46-3

Description: BCTP is a polymodal inhibitor of TRPV1 with a reduced liability for hyperthermia.

Chemical Structure

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BCTP
CAS# 464152-46-3
Instruction

Theoretical Analysis

MedKoo Cat#: 562732
Name: BCTP
CAS#: 464152-46-3
Chemical Formula: C17H16ClN3OS
Exact Mass: 345.07
Molecular Weight: 345.840
Elemental Analysis: C, 59.04; H, 4.66; Cl, 10.25; N, 12.15; O, 4.63; S, 9.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BCTP;

IUPAC/Chemical Name: 7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one

InChi Key: BOBBYBHJYYJHHQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H16ClN3OS/c1-17(2,3)13-11(9-4-6-10(18)7-5-9)8-12-14(19-13)20-16(23)21-15(12)22/h4-8H,1-3H3,(H2,19,20,21,22,23)

SMILES Code: O=C(N1)C2=CC(C3=CC=C(Cl)C=C3)=C(C(C)(C)C)N=C2NC1=S

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 345.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nash MS, McIntyre P, Groarke A, Lilley E, Culshaw A, Hallett A, Panesar M, Fox A, Bevan S. 7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4 -one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hypersensitivity. J Pharmacol Exp Ther. 2012 Aug;342(2):389-98. doi: 10.1124/jpet.112.191932. Epub 2012 May 7. PubMed PMID: 22566669.

2: Wang YH, Fu R, Shao ZH, Wang HQ, Xing LM, Liu H, Wu YH, Li LJ, Liu H, Wang J, Chen J, Wang HL. [Study on quantity and function of bone marrow macrophages in patients with BMMNC-Coombs Test(+) pancytopenia]. Zhonghua Xue Ye Xue Za Zhi. 2009 Aug;30(8):538-42. Chinese. PubMed PMID: 19954642.

3: Teixeira PC, Leite GM, Domingues RJ, Silva J, Gibbs PA, Ferreira JP. Antimicrobial effects of a microemulsion and a nanoemulsion on enteric and other pathogens and biofilms. Int J Food Microbiol. 2007 Aug 15;118(1):15-9. Epub 2007 Jun 12. PubMed PMID: 17610974.

4: Hamouda T, Hayes MM, Cao Z, Tonda R, Johnson K, Wright DC, Brisker J, Baker JR Jr. A novel surfactant nanoemulsion with broad-spectrum sporicidal activity against Bacillus species. J Infect Dis. 1999 Dec;180(6):1939-49. PubMed PMID: 10558951.

5: BCTP sounds its battle cry. Environ Health Perspect. 1999 Feb;107(2):A64-5. PubMed PMID: 10348630; PubMed Central PMCID: PMC1566347.

6: Koronakis V, Hughes C, Koronakis E. ATPase activity and ATP/ADP-induced conformational change in the soluble domain of the bacterial protein translocator HlyB. Mol Microbiol. 1993 Jun;8(6):1163-75. PubMed PMID: 8361361.