ICR 283

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591039

CAS#: 38915-21-8

Description: ICR 283 is a therapeutic agent.

Chemical Structure

ICR 283
CAS# 38915-21-8

Theoretical Analysis

MedKoo Cat#: 591039
Name: ICR 283
CAS#: 38915-21-8
Chemical Formula: C18H19Cl3N2O2
Exact Mass: 400.0512
Molecular Weight: 401.71
Elemental Analysis: C, 53.82; H, 4.77; Cl, 26.47; N, 6.97; O, 7.97

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ICR 283; ICR-283; ICR283

IUPAC/Chemical Name: 9-Acridinamine, 6-chloro-N-(2-(2-chloroethoxy)ethyl)-2-methoxy-, hydrochloride


InChi Code: InChI=1S/C18H18Cl2N2O2.ClH/c1-23-13-3-5-16-15(11-13)18(21-7-9-24-8-6-19)14-4-2-12(20)10-17(14)22-16;/h2-5,10-11H,6-9H2,1H3,(H,21,22);1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 401.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Pandy V, Narasingam M, Vijeepallam K, Mohan S, Mani V, Mohamed Z. The ethyl acetate fraction of a methanolic extract of unripe noni (Morinda citrifolia Linn.) fruit exhibits a biphasic effect on the dopaminergic system in mice. Exp Anim. 2017 Aug 5;66(3):283-291. doi: 10.1538/expanim.16-0105. Epub 2017 Apr 26. PubMed PMID: 28450692; PubMed Central PMCID: PMC5543249.

2: Rho TW, Lee SY, Han SY, Kim JH, Lee KH, Kim DS, Kwak HB, Kim YK. Glycyrrhizae Radix Inhibits Osteoclast Differentiation by Inhibiting c-Fos-Dependent NFATc1 Expression. Am J Chin Med. 2017;45(2):283-298. doi: 10.1142/S0192415X17500185. Epub 2017 Feb 23. PubMed PMID: 28231743.

3: Morris O, Liu X, Domingues C, Runchel C, Chai A, Basith S, Tenev T, Chen H, Choi S, Pennetta G, Buchon N, Meier P. Signal Integration by the IκB Protein Pickle Shapes Drosophila Innate Host Defense. Cell Host Microbe. 2016 Sep 14;20(3):283-295. doi: 10.1016/j.chom.2016.08.003. PubMed PMID: 27631699; PubMed Central PMCID: PMC5026699.

4: Gong C, Qian L, Yang H, Ji LL, Wei H, Zhou WB, Qi C, Wang CH. Hepatotoxicity and pharmacokinetics of cisplatin in combination therapy with a traditional Chinese medicine compound of Zengmian Yiliu granules in ICR mice and SKOV-3-bearing nude mice. BMC Complement Altern Med. 2015 Aug 18;15:283. doi: 10.1186/s12906-015-0799-9. PubMed PMID: 26283082; PubMed Central PMCID: PMC4538754.

5: Su X, Pei Z, Hu S. Ginsenoside Re as an adjuvant to enhance the immune response to the inactivated rabies virus vaccine in mice. Int Immunopharmacol. 2014 Jun;20(2):283-9. doi: 10.1016/j.intimp.2014.03.008. Epub 2014 Mar 25. PubMed PMID: 24680943.

6: Jeon YM, Kim WJ, Lee MY. Studies on liver damage induced by nanosized-titanium dioxide in mouse. J Environ Biol. 2013 Mar;34(2):283-7. PubMed PMID: 24620593.

7: Li P, Jia J, Zhang D, Xie J, Xu X, Wei D. In vitro and in vivo antioxidant activities of a flavonoid isolated from celery (Apium graveolens L. var. dulce). Food Funct. 2014 Jan;5(1):50-6. doi: 10.1039/c3fo60273g. PubMed PMID: 24232123.

8: Tian Y, Ma S, Lin B, Kou J, Yu B. Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari. Indian J Pharmacol. 2013 May-Jun;45(3):283-5. doi: 10.4103/0253-7613.111896. PubMed PMID: 23833374; PubMed Central PMCID: PMC3696302.

9: Jiang XH, Yie SM, Zhen X, Den YL, Liang X, Hu X, Li LM, Li QJ, Cao S, Lu H. Effect of You Gui Wan on mouse sperm fertilising ability in vivo and in vitro. Andrologia. 2014 Apr;46(3):283-9. doi: 10.1111/and.12075. Epub 2013 Mar 6. PubMed PMID: 23465132.

10: You F, Ren W, Gu S, Wang W, Zhou L, Zhang Y, Gan W, Chen M. First BAFF gene cloned from an aquatic mammal. Gene. 2012 Aug 1;504(1):13-21. doi: 10.1016/j.gene.2012.05.001. Epub 2012 May 12. PubMed PMID: 22588026.

11: Han H, Chen Y, Bi H, Yu L, Sun C, Li S, Oumar SA, Zhou Y. In vivo antimalarial activity of ginseng extracts. Pharm Biol. 2011 Mar;49(3):283-9. doi: 10.3109/13880209.2010.511235. PubMed PMID: 21323481.

12: Turner NC, Ashworth A. Biomarkers of PARP inhibitor sensitivity. Breast Cancer Res Treat. 2011 May;127(1):283-6. doi: 10.1007/s10549-011-1375-8. Epub 2011 Feb 8. PubMed PMID: 21301956.

13: Ano Y, Nakayama H, Sakudo A, Sawano Y, Tanokura M, Itohara S, Onodera T. Intestinal uptake of amyloid beta protein through columnar epithelial cells in suckling mice. Histol Histopathol. 2009 Mar;24(3):283-92. doi: 10.14670/HH-24.283. PubMed PMID: 19130397.

14: Song H, Luo J, Luo W, Weng J, Wang Z, Li B, Li D, Liu M. Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway. J Biol Chem. 2008 Dec 26;283(52):36687-97. doi: 10.1074/jbc.M800721200. Epub 2008 Oct 27. PubMed PMID: 18955481; PubMed Central PMCID: PMC2605983.

15: Qin D, Gan Y, Shao K, Wang H, Li W, Wang T, He W, Xu J, Zhang Y, Kou Z, Zeng L, Sheng G, Esteban MA, Gao S, Pei D. Mouse meningiocytes express Sox2 and yield high efficiency of chimeras after nuclear reprogramming with exogenous factors. J Biol Chem. 2008 Nov 28;283(48):33730-5. doi: 10.1074/jbc.M806788200. Epub 2008 Sep 29. PubMed PMID: 18826945; PubMed Central PMCID: PMC2662282.

16: Ishii M, Maeda N. Oversulfated chondroitin sulfate plays critical roles in the neuronal migration in the cerebral cortex. J Biol Chem. 2008 Nov 21;283(47):32610-20. doi: 10.1074/jbc.M806331200. Epub 2008 Sep 26. PubMed PMID: 18819920.

17: Shinomura T, Nakamura S, Ito K, Shirasawa S, Höök M, Kimura JH. Adsorption of follicular dendritic cell-secreted protein (FDC-SP) onto mineral deposits. Application of a new stable gene expression system. J Biol Chem. 2008 Nov 28;283(48):33658-64. doi: 10.1074/jbc.M800719200. Epub 2008 Sep 19. PubMed PMID: 18806264; PubMed Central PMCID: PMC2662279.

18: Das A, Xi L, Kukreja RC. Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta. J Biol Chem. 2008 Oct 24;283(43):29572-85. doi: 10.1074/jbc.M801547200. Epub 2008 Aug 21. PubMed PMID: 18723505; PubMed Central PMCID: PMC2570896.

19: Sabbatini ME, Chen X, Ernst SA, Williams JA. Rap1 activation plays a regulatory role in pancreatic amylase secretion. J Biol Chem. 2008 Aug 29;283(35):23884-94. doi: 10.1074/jbc.M800754200. Epub 2008 Jun 24. PubMed PMID: 18577515; PubMed Central PMCID: PMC2527106.

20: deSouza NM, Riches SF, Vanas NJ, Morgan VA, Ashley SA, Fisher C, Payne GS, Parker C. Diffusion-weighted magnetic resonance imaging: a potential non-invasive marker of tumour aggressiveness in localized prostate cancer. Clin Radiol. 2008 Jul;63(7):774-82. doi: 10.1016/j.crad.2008.02.001. Epub 2008 Apr 18. PubMed PMID: 18555035.