D-703

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596063

CAS#: 67018-80-8

Description: D-703 is a bioactive chemical.


Price and Availability

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D-703 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596063
Name: D-703
CAS#: 67018-80-8
Chemical Formula: C26H36N2O4
Exact Mass: 440.2675
Molecular Weight: 440.58
Elemental Analysis: C, 70.88; H, 8.24; N, 6.36; O, 14.53


Synonym: D-703; D 715; D-715; D715; D 703; D703; D-703, (+/-)-; J431.058F; PR 23; (+/-)-PR-23;

IUPAC/Chemical Name: 5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(4-hydroxy-3-methoxyphenyl)-2-isopropylpentanenitrile

InChi Key: WLKVZSXOMGNZLB-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H36N2O4/c1-19(2)26(18-27,21-9-10-22(29)24(17-21)31-5)13-7-14-28(3)15-12-20-8-11-23(30-4)25(16-20)32-6/h8-11,16-17,19,29H,7,12-15H2,1-6H3

SMILES Code: N#CC(C(C)C)(CCCN(CCC1=CC=C(OC)C(OC)=C1)C)C2=CC=C(O)C(OC)=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Kelly J, Hughes CM, Harrison RF. The hidden costs of IVF. Ir Med J. 2006 May;99(5):142-3. PubMed PMID: 16892919.

2: Georgiadis D, Stets R, Schorch A, Baumgartner RW, Bernet F, Zerkowski HR. Doppler microembolic signals during cardiopulmonary bypass: comparison of two membrane oxygenators. Neurol Res. 2004 Jan;26(1):99-102. PubMed PMID: 14977066.

3: Läpple F, von Richter O, Fromm MF, Richter T, Thon KP, Wisser H, Griese EU, Eichelbaum M, Kivistö KT. Differential expression and function of CYP2C isoforms in human intestine and liver. Pharmacogenetics. 2003 Sep;13(9):565-75. PubMed PMID: 12972955.

4: Borlak J, Walles M, Levsen K, Thum T. Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells. Drug Metab Dispos. 2003 Jul;31(7):888-91. PubMed PMID: 12814965.

5: von Richter O, Eichelbaum M, Schönberger F, Hofmann U. Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl. 2000 Jan 28;738(1):137-47. PubMed PMID: 10778935.

6: Pauli-Magnus C, von Richter O, Burk O, Ziegler A, Mettang T, Eichelbaum M, Fromm MF. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82. PubMed PMID: 10773005.

7: Busse D, Cosme J, Beaune P, Kroemer HK, Eichelbaum M. Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1995 Dec;353(1):116-21. PubMed PMID: 8750925.