WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596063
Description: D-703 is a bioactive chemical.
MedKoo Cat#: 596063
Chemical Formula: C26H36N2O4
Exact Mass: 440.2675
Molecular Weight: 440.58
Elemental Analysis: C, 70.88; H, 8.24; N, 6.36; O, 14.53
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: D-703; D 715; D-715; D715; D 703; D703; D-703, (+/-)-; J431.058F; PR 23; (+/-)-PR-23;
IUPAC/Chemical Name: 5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(4-hydroxy-3-methoxyphenyl)-2-isopropylpentanenitrile
InChi Key: WLKVZSXOMGNZLB-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H36N2O4/c1-19(2)26(18-27,21-9-10-22(29)24(17-21)31-5)13-7-14-28(3)15-12-20-8-11-23(30-4)25(16-20)32-6/h8-11,16-17,19,29H,7,12-15H2,1-6H3
SMILES Code: N#CC(C(C)C)(CCCN(CCC1=CC=C(OC)C(OC)=C1)C)C2=CC=C(O)C(OC)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 440.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Kelly J, Hughes CM, Harrison RF. The hidden costs of IVF. Ir Med J. 2006 May;99(5):142-3. PubMed PMID: 16892919.
2: Georgiadis D, Stets R, Schorch A, Baumgartner RW, Bernet F, Zerkowski HR. Doppler microembolic signals during cardiopulmonary bypass: comparison of two membrane oxygenators. Neurol Res. 2004 Jan;26(1):99-102. PubMed PMID: 14977066.
3: Läpple F, von Richter O, Fromm MF, Richter T, Thon KP, Wisser H, Griese EU, Eichelbaum M, Kivistö KT. Differential expression and function of CYP2C isoforms in human intestine and liver. Pharmacogenetics. 2003 Sep;13(9):565-75. PubMed PMID: 12972955.
4: Borlak J, Walles M, Levsen K, Thum T. Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells. Drug Metab Dispos. 2003 Jul;31(7):888-91. PubMed PMID: 12814965.
5: von Richter O, Eichelbaum M, Schönberger F, Hofmann U. Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl. 2000 Jan 28;738(1):137-47. PubMed PMID: 10778935.
6: Pauli-Magnus C, von Richter O, Burk O, Ziegler A, Mettang T, Eichelbaum M, Fromm MF. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82. PubMed PMID: 10773005.
7: Busse D, Cosme J, Beaune P, Kroemer HK, Eichelbaum M. Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1995 Dec;353(1):116-21. PubMed PMID: 8750925.