K 259-2

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558019

CAS#: 102819-46-5

Description: K 259-2 is a phosphodiesterase inhibitor.


Chemical Structure

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K 259-2
CAS# 102819-46-5

Theoretical Analysis

MedKoo Cat#: 558019
Name: K 259-2
CAS#: 102819-46-5
Chemical Formula: C21H18O7
Exact Mass: 382.11
Molecular Weight: 382.37
Elemental Analysis: C, 65.97; H, 4.75; O, 29.29

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: K259-2; K 259-2; K 2592

IUPAC/Chemical Name: 1,6,8-Trihydroxy-3-[(Z)-2-ethyl-2-butenyl]-9,10-dihydro-9,10-dioxoanthracene-2-carboxylic acid

InChi Key: SYTAMFWHVQWAKV-OQFOIZHKSA-N

InChi Code: 1S/C21H18O7/c1-3-9(4-2)5-10-6-12-17(19(25)15(10)21(27)28)20(26)16-13(18(12)24)7-11(22)8-14(16)23/h3,6-8,22-23,25H,4-5H2,1-2H3,(H,27,28)/b9-3-

SMILES Code: c1(c(c(cc2C(c3cc(cc(c3C(c12)=O)O)O)=O)C\C(=C/C)CC)C(=O)O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 382.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Chen JW, Li X, Zhao HM. [Analysis of vitamins and inorganic elements in the water extracts of Radix Changii]. Zhong Xi Yi Jie He Xue Bao. 2004 Sep;2(5):379-81. Chinese. PubMed PMID: 15383265.

2: Matsuda Y, Nakanishi S, Nagasawa K, Kase H. Inhibition by new anthraquinone compounds, K-259-2 and KS-619-1, of calmodulin-dependent cyclic nucleotide phosphodiesterase. Biochem Pharmacol. 1990 Mar 1;39(5):841-9. PubMed PMID: 2155616.

3: Yasuzawa T, Yoshida M, Shirahata K, Sano H. Structure of a novel Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor K-259-2. J Antibiot (Tokyo). 1987 Aug;40(8):1101-3. PubMed PMID: 3680021.

4: Matsuda Y, Asano K, Kawamoto I, Kase H. K-259-2, a new inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase from Micromonospora olivasterospora. J Antibiot (Tokyo). 1987 Aug;40(8):1092-100. PubMed PMID: 3680020.