J9
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555254

CAS#: 947018-15-7

Description: J9 is a Glucocorticoid resistance inhibitor. J9 Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL).

Chemical Structure

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J9
CAS# 947018-15-7
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 555254
Name: J9
CAS#: 947018-15-7
Chemical Formula: C12H12N4
Exact Mass: 212.1062
Molecular Weight: 212.256
Elemental Analysis: C, 67.90; H, 5.70; N, 26.40

Size Price Shipping out time Quantity
1g USD 2950 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2021-03-05. Prices are subject to change without notice.

J9 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: J9; J 9; J-9.

IUPAC/Chemical Name: 4-cyclopropyl-5-(pyridin-4-yl)pyrimidin-2-amine

InChi Key: PQLYPFZAOUDDHB-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H12N4/c13-12-15-7-10(8-3-5-14-6-4-8)11(16-12)9-1-2-9/h3-7,9H,1-2H2,(H2,13,15,16)

SMILES Code: NC1=NC=C(C2=CC=NC=C2)C(C3CC3)=N1

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 212.256 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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1: Cantley AM, Welsch M, Ambesi-Impiombato A, Sanchez-Martin M, Kim MY, Bauer A,
Ferrando A, Stockwell BR. Small Molecule that Reverses Dexamethasone Resistance
in T-cell Acute Lymphoblastic Leukemia (T-ALL). ACS Med Chem Lett. 2014 Apr
25;5(7):754-9. doi: 10.1021/ml500044g. eCollection 2014 Jul 10. PubMed PMID:
25050160; PubMed Central PMCID: PMC4094258.

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J9

1g / USD 2950