WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555254
Description: J9 is a Glucocorticoid resistance inhibitor. J9 Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL).
MedKoo Cat#: 555254
Chemical Formula: C12H12N4
Exact Mass: 212.1062
Molecular Weight: 212.256
Elemental Analysis: C, 67.90; H, 5.70; N, 26.40
J9 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: J9; J 9; J-9.
IUPAC/Chemical Name: 4-cyclopropyl-5-(pyridin-4-yl)pyrimidin-2-amine
InChi Key: PQLYPFZAOUDDHB-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H12N4/c13-12-15-7-10(8-3-5-14-6-4-8)11(16-12)9-1-2-9/h3-7,9H,1-2H2,(H2,13,15,16)
SMILES Code: NC1=NC=C(C2=CC=NC=C2)C(C3CC3)=N1
The following data is based on the product molecular weight 212.256 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Cantley AM, Welsch M, Ambesi-Impiombato A, Sanchez-Martin M, Kim MY, Bauer A,
Ferrando A, Stockwell BR. Small Molecule that Reverses Dexamethasone Resistance
in T-cell Acute Lymphoblastic Leukemia (T-ALL). ACS Med Chem Lett. 2014 Apr
25;5(7):754-9. doi: 10.1021/ml500044g. eCollection 2014 Jul 10. PubMed PMID:
25050160; PubMed Central PMCID: PMC4094258.