WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555253

CAS#: 78950-78-4 (free base)

Description: 8-OH-DPAT is a 5HT-1a agonist.

Chemical Structure

CAS# 78950-78-4 (free base)

Theoretical Analysis

MedKoo Cat#: 555253
Name: 8-OH-DPAT
CAS#: 78950-78-4 (free base)
Chemical Formula: C16H25NO
Exact Mass: 247.1936
Molecular Weight: 247.382
Elemental Analysis: C, 77.68; H, 10.19; N, 5.66; O, 6.47

Price and Availability

Size Price Availability Quantity
200.0mg USD 1050.0 2 Weeks
500.0mg USD 1650.0 2 Weeks
1.0g USD 2950.0 2 Weeks
2.0g USD 4750.0 2 Weeks
5.0g USD 6950.0 2 Weeks
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Related CAS #: 76135-31-4 (HBr)   78950-78-4 (free base)   141215-27-2 (HCl)    

Synonym: 8-OH-DPAT; 8-Hydroxy-DPAT; 8OH-DPAT;

IUPAC/Chemical Name: 8-Hydroxy-2-(di-n-propylamino)tetralin


InChi Code: InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 247.382 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pfitzer S, Laubscher L, Meyer L, Warren K, Vaughan-Higgins R, Raath JP, Laurence M. Dose-effect study of the serotonin agonist R-8-OH-DPAT on opioid-induced respiratory depression in blesbok (Damaliscus pygargus philipsi) and impala (Aepyceros melampus). Vet Anaesth Analg. 2019 Jul 6. pii: S1467-2987(19)30170-9. doi: 10.1016/j.vaa.2019.06.006. [Epub ahead of print] PubMed PMID: 31521514.

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3: Gener T, Tauste Campo A, Alemany-González M, Nebot P, Delgado-Sallent C, Chanovas J, Puig MV. Serotonin 5-HT(1A), 5-HT(2A) and dopamine D(2) receptors strongly influence prefronto-hippocampal neural networks in alert mice: Contribution to the actions of risperidone. Neuropharmacology. 2019 Nov 1;158:107743. doi: 10.1016/j.neuropharm.2019.107743. Epub 2019 Aug 17. PubMed PMID: 31430459.

4: Ahmadi SA, Sabahi M, Haddadi R. The effect of acute and repeated administration of buspirone, 8-OHDPAT and fluoxetine on haloperidol-induced extrapyramidal symptoms. Neuropsychopharmacol Hung. 2019 Jun;21(2):59-68. PubMed PMID: 31378723.

5: Wang Y, Liu Y, Xiong J, Di T, Yuan Z, Wu J, Chen L. Reduced serotonin impairs long-term depression in basolateral amygdala complex and causes anxiety-like behaviors in a mouse model of perimenopause. Exp Neurol. 2019 Nov;321:113030. doi: 10.1016/j.expneurol.2019.113030. Epub 2019 Aug 1. PubMed PMID: 31377402.

6: Newman-Tancredi A, Cussac D, Ormière AM, Lestienne F, Varney MA, Martel JC. Bell-shaped agonist activation of 5-HT(1A) receptor-coupled Gαi(3) G-proteins: Receptor density-dependent switch in receptor signaling. Cell Signal. 2019 Nov;63:109383. doi: 10.1016/j.cellsig.2019.109383. Epub 2019 Jul 31. PubMed PMID: 31376526.

7: Shioda N, Imai Y, Yabuki Y, Sugimoto W, Yamaguchi K, Wang Y, Hikida T, Sasaoka T, Mieda M, Fukunaga K. Dopamine D(2L) Receptor Deficiency Causes Stress Vulnerability through 5-HT(1A) Receptor Dysfunction in Serotonergic Neurons. J Neurosci. 2019 Aug 1. pii: 0079-19. doi: 10.1523/JNEUROSCI.0079-19.2019. [Epub ahead of print] PubMed PMID: 31371425.

8: Wang L, He Z, Zhu Z, Yuan W, Cai W, Li L, Zhang J, Hou W, Yang Y, Zhang X, Guo Q, Wang X, Lian Z, Tai F. The serotonin system in the hippocampus CA3 involves in effects of CSDS on social recognition in adult female mandarin voles (Microtus mandarinus). Prog Neuropsychopharmacol Biol Psychiatry. 2019 Dec 20;95:109704. doi: 10.1016/j.pnpbp.2019.109704. Epub 2019 Jul 19. PubMed PMID: 31330217.

9: Brandenburg C, Blatt GJ. Differential serotonin transporter (5-HTT) and 5-HT(2) receptor density in limbic and neocortical areas of adults and children with ASD: implications for SSRI efficacy. J Neurochem. 2019 Jul 20. doi: 10.1111/jnc.14832. [Epub ahead of print] PubMed PMID: 31325179.

10: Nguyen HTT, Cho DH, Jang SH, Han SK, Park SJ. Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice. Korean J Physiol Pharmacol. 2019 Jul;23(4):271-279. doi: 10.4196/kjpp.2019.23.4.271. Epub 2019 Jun 25. PubMed PMID: 31297011; PubMed Central PMCID: PMC6609265.

11: Groft ML, Normann MC, Nicklas PR, Jagielo-Miller JE, McLaughlin PJ. Biphasic effects of 5-HT(1A) agonism on impulsive responding are dissociable from effects on anxiety in the variable consecutive number task. Naunyn Schmiedebergs Arch Pharmacol. 2019 Jul 9. doi: 10.1007/s00210-019-01684-5. [Epub ahead of print] PubMed PMID: 31289857.

12: Yang Y, Lin D, Bao C, Huang H, Ye H. Serotonergic Mechanisms of Oocyte Germinal Vesicle Breakdown in the Mud Crab, Scylla paramamosain. Front Physiol. 2019 Jun 19;10:797. doi: 10.3389/fphys.2019.00797. eCollection 2019. PubMed PMID: 31275175; PubMed Central PMCID: PMC6593242.

13: Odland AU, Jessen L, Fitzpatrick CM, Andreasen JT. 8-OH-DPAT Induces Compulsive-like Deficit in Spontaneous Alternation Behavior: Reversal by MDMA but Not Citalopram. ACS Chem Neurosci. 2019 Jul 17;10(7):3094-3100. doi: 10.1021/acschemneuro.8b00593. Epub 2019 Jun 17. PubMed PMID: 31244057.

14: Xiao WZ, Zhou WH, Ma Q, Cui WG, Mei QY, Zhao X. Serotonergically dependent antidepressant-like activity on behavior and stress axis responsivity of acacetin. Pharmacol Res. 2019 Aug;146:104310. doi: 10.1016/j.phrs.2019.104310. Epub 2019 Jun 20. PubMed PMID: 31229563.

15: Redfern WS, Dymond A, Strang I, Storey S, Grant C, Marks L, Barnard C, Heys C, Moyser K, Greenwood K, Cobey D, Moore N, Karp NA, Prior H. The functional observational battery and modified Irwin test as global neurobehavioral assessments in the rat: Pharmacological validation data and a comparison of methods. J Pharmacol Toxicol Methods. 2019 Jul - Aug;98:106591. doi: 10.1016/j.vascn.2019.106591. Epub 2019 May 27. PubMed PMID: 31146025.

16: Zhou X, Li G, Zhang S, Wu J. 5-HT1A Receptor Agonist Promotes Retinal Ganglion Cell Function by Inhibiting OFF-Type Presynaptic Glutamatergic Activity in a Chronic Glaucoma Model. Front Cell Neurosci. 2019 May 3;13:167. doi: 10.3389/fncel.2019.00167. eCollection 2019. PubMed PMID: 31130845; PubMed Central PMCID: PMC6509153.

17: Nagata A, Nakayama K, Nakamura S, Mochizuki A, Gemba C, Aoki R, Dantsuji M, Maki K, Inoue T. Serotonin(1B) receptor-mediated presynaptic inhibition of proprioceptive sensory inputs to jaw-closing motoneurons. Brain Res Bull. 2019 Jul;149:260-267. doi: 10.1016/j.brainresbull.2019.05.001. Epub 2019 May 7. PubMed PMID: 31075304.

18: Higgs J, Wasowski C, Marcos A, Jukič M, Paván CH, Gobec S, de Tezanos Pinto F, Colettis N, Marder M. Chalcone derivatives: synthesis, in vitro and in vivo evaluation of their anti-anxiety, anti-depression and analgesic effects. Heliyon. 2019 Mar 19;5(3):e01376. doi: 10.1016/j.heliyon.2019.e01376. eCollection 2019 Mar. PubMed PMID: 30949609; PubMed Central PMCID: PMC6430037.

19: Depoortère R, Bardin L, Varney MA, Newman-Tancredi A. Serotonin 5-HT(1A) Receptor Biased Agonists Display Differential Anxiolytic Activity in a Rat Social Interaction Model. ACS Chem Neurosci. 2019 Jul 17;10(7):3101-3107. doi: 10.1021/acschemneuro.8b00661. Epub 2019 Apr 2. PubMed PMID: 30929419.

20: Lapointe T, Hudson R, Daniels S, Melanson B, Zhou Y, Leri F. Effects of combined escitalopram and aripiprazole in rats: role of the 5-HT(1a) receptor. Psychopharmacology (Berl). 2019 Jul;236(7):2273-2281. doi: 10.1007/s00213-019-05225-z. Epub 2019 Mar 22. Erratum in: Psychopharmacology (Berl). 2019 May 22;:. PubMed PMID: 30903210.


200.0mg / USD 1050.0