Gabapentin HCl
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MedKoo CAT#: 571570

CAS#: 60142-95-2 (HCl)

Description: Gabapentin is an oral medication for add-on therapy in the treatment of partial seizures in adult epilepsy; inhibits dopamine release from rabbit caudate nucleus.


Price and Availability

Size
Price

100mg
USD 350
Size
Price

500mg
USD 950
Size
Price

Gabapentin HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571570
Name: Gabapentin HCl
CAS#: 60142-95-2 (HCl)
Chemical Formula: C9H18ClNO2
Exact Mass: 171.1259
Molecular Weight: 207.698
Elemental Analysis: C, 52.05; H, 8.74; Cl, 17.07; N, 6.74; O, 15.41


Related CAS #: 60142-95-2 (HCl)   60142-96-3 (free base)    

Synonym: Gabapentin HCl; Gabapentin hydrochloride

IUPAC/Chemical Name: 1-(Aminomethyl)cyclohexaneacetic acid HCl

InChi Key: XBUDZAQEMFGLEU-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H17NO2.ClH/c10-7-9(6-8(11)12)4-2-1-3-5-9;/h1-7,10H2,(H,11,12);1H

SMILES Code: O=C(O)CC1(CN)CCCCC1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Qiu R, Perrino AC Jr, Zurich H, Sukumar N, Dai F, Popescu W. Effect of preoperative gabapentin and acetaminophen on opioid consumption in video-assisted thoracoscopic surgery: a retrospective study. Rom J Anaesth Intensive Care. 2018 Apr;25(1):43-48. doi: 10.21454/rjaic.7518.251.gab. PubMed PMID: 29756062; PubMed Central PMCID: PMC5931182.

2: Sicras-Mainar A, Rejas-Gutiérrez J, Perez-Paramo M, Navarro-Artieda R. Cost of treating peripheral neuropathic pain with pregabalin or gabapentin at therapeutic doses in routine practice. J Comp Eff Res. 2018 May 14. doi: 10.2217/cer-2018-0008. [Epub ahead of print] PubMed PMID: 29754518.

3: Crisologo PA, Monson EK, Atway SA. Gabapentin as an Adjunct to Standard Postoperative Pain Management Protocol in Lower Extremity Surgery. J Foot Ankle Surg. 2018 May 7. pii: S1067-2516(18)30059-0. doi: 10.1053/j.jfas.2018.02.005. [Epub ahead of print] Review. PubMed PMID: 29748103.

4: Brown CS, Bachmann GA, Wan J, Foster DC; Gabapentin (GABA) Study Group. Gabapentin for the Treatment of Vulvodynia: A Randomized Controlled Trial. Obstet Gynecol. 2018 May 7. doi: 10.1097/AOG.0000000000002617. [Epub ahead of print] PubMed PMID: 29742655.

5: Leung JG, Rakocevic DB, Allen ND, Handler EM, Perossa BA, Borreggine KL, Stark AL, Betcher HK, Hosker DK, Minton BA, Braus BR, Dierkhising RA, Philbrick KL. Use of a Gabapentin Protocol for the Management of Alcohol Withdrawal: A Preliminary Experience Expanding From the Consultation-Liaison Psychiatry Service. Psychosomatics. 2018 Mar 21. pii: S0033-3182(18)30138-5. doi: 10.1016/j.psym.2018.03.002. [Epub ahead of print] PubMed PMID: 29735241.

6: Ölçücü MT, Ölçücü N, Ölçücüoğlu E, Ölçücüoğlu EA, Özgök Y. Response to duloxetine and gabapentin combination of a patient who has chronical orchialgia with bilateral tubular ectasia of rete testis and multiple epididymal cysts. Turk J Urol. 2018 May;44(3):274-277. doi: 10.5152/tud.2017.17999. Epub 2017 Mar 7. PubMed PMID: 29733802; PubMed Central PMCID: PMC5937648.

7: Chakrabarty S, Ghosh B, Giri TK, Khanam J. Reverse iontophoretic extraction of gabapentin: a mechanistic study. Curr Drug Deliv. 2018 May 3. doi: 10.2174/1567201815666180503122309. [Epub ahead of print] PubMed PMID: 29732968.

8: Cakici ÖU, Hamidi N, Ürer E, Okulu E, Kayigil O. Efficacy of sertraline and gabapentin in the treatment of urethral pain syndrome: retrospective results of a single institutional cohort. Cent European J Urol. 2018;71(1):78-83. doi: 10.5173/ceju.2018.1574. Epub 2017 Jan 16. PubMed PMID: 29732211; PubMed Central PMCID: PMC5926640.

9: Kendall MC, Castro-Alves LJ. Gabapentin to Prevent Acute Phantom-Limb Pain in Pediatric Patients Undergoing Amputation. J Pain Symptom Manage. 2018 May 2. pii: S0885-3924(18)30227-6. doi: 10.1016/j.jpainsymman.2018.04.010. [Epub ahead of print] PubMed PMID: 29729349.

10: Baxter KJ, Hafling J, Sterner J, Patel AU, Giannopoulos H, Heiss KF, Raval MV. Effectiveness of gabapentin as a postoperative analgesic in children undergoing appendectomy. Pediatr Surg Int. 2018 May 4. doi: 10.1007/s00383-018-4274-9. [Epub ahead of print] PubMed PMID: 29728759.

11: Peckham AM, Fairman KA, Sclar DA. Authors' Reply to: Tomoyuki Kawada's Comment on: "All-Cause and Drug-Related Medical Events Associated with Overuse of Gabapentin and/or Opioid Medications: A Retrospective Cohort Analysis of a Commercially Insured US Population''. Drug Saf. 2018 May 3. doi: 10.1007/s40264-018-0671-1. [Epub ahead of print] PubMed PMID: 29725941.

12: Kawada T. Comment on: "All-Cause and Drug-Related Medical Events Associated with Overuse of Gabapentin and/or Opioid Medications: A Retrospective Cohort Analysis of a Commercially Insured US Population". Drug Saf. 2018 May 3. doi: 10.1007/s40264-018-0670-2. [Epub ahead of print] PubMed PMID: 29725940.

13: Sanders J, Cameron C, Dawes P. Response to "Gabapentin to Prevent Acute Pain after Tonsillectomy". Otolaryngol Head Neck Surg. 2018 May;158(5):963-964. doi: 10.1177/0194599818761874. PubMed PMID: 29714109.

14: Kendall MC, Castro-Alves LJ. Gabapentin to Prevent Acute Pain after Tonsillectomy. Otolaryngol Head Neck Surg. 2018 May;158(5):963. doi: 10.1177/0194599818761873. PubMed PMID: 29714108.

15: King HH. Fibromyalgia Symptoms Reduced by Osteopathic Manipulative Medicine and Gabapentin. J Am Osteopath Assoc. 2018 May 1;118(5):349-350. doi: 10.7556/jaoa.2018.071. PubMed PMID: 29710361.

16: Townsend M, Liou T, Kallogjeri D, Schoer M, Scott-Wittenborn N, Lindburg M, Bottros M, Jackson RS, Nussenbaum B, Piccirillo JF. Effect of Perioperative Gabapentin Use on Postsurgical Pain in Patients Undergoing Head and Neck Mucosal Surgery: A Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2018 Apr 19. doi: 10.1001/jamaoto.2018.0282. [Epub ahead of print] PubMed PMID: 29710075.

17: Bellessort B, Bachelot A, Grouthier V, De Lombares C, Narboux-Neme N, Garagnani P, Pirazzini C, Astigiano S, Mastracci L, Fontaine A, Alfama G, Duvernois-Berthet E, Levi G. Comparative analysis of molecular signatures suggests the use of gabapentin for the management of endometriosis-associated pain. J Pain Res. 2018 Apr 10;11:715-725. doi: 10.2147/JPR.S163611. eCollection 2018. PubMed PMID: 29692624; PubMed Central PMCID: PMC5903492.

18: Akanuma SI, Yamakoshi A, Sugouchi T, Kubo Y, Hartz AMS, Bauer B, Hosoya KI. Role of l-Type Amino Acid Transporter 1 at the Inner Blood-Retinal Barrier in the Blood-to-Retina Transport of Gabapentin. Mol Pharm. 2018 May 2. doi: 10.1021/acs.molpharmaceut.8b00179. [Epub ahead of print] PubMed PMID: 29688723.

19: Schmidt P, Rao S. Effects of gabapentin, pregabalin and gastroretentive gabapentin on simulated driving, daytime sedation and cognition. Pain Manag. 2018 Apr 19. doi: 10.2217/pmt-2018-0005. [Epub ahead of print] PubMed PMID: 29671676.

20: Staller K, Thurler AH, Reynolds JS, Dimisko LR, McGovern R, Skarbinski KF, Kuo B. Gabapentin Improves Symptoms of Functional Dyspepsia in a Retrospective, Open-label Cohort Study. J Clin Gastroenterol. 2018 Apr 17. doi: 10.1097/MCG.0000000000001034. [Epub ahead of print] PubMed PMID: 29668559.