WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596011
Description: J-104871 is a FTase inhibitor. It has been found that J-104,871 inhibits FTase in an FPP-competitive manner in whole cells as well as in the in vitro system. Furthermore, J-104,871 suppressed tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.
MedKoo Cat#: 596011
Chemical Formula: C38H32N2O12
Exact Mass: 708.1955
Molecular Weight: 708.67
Elemental Analysis: C, 64.40; H, 4.55; N, 3.95; O, 27.09
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Synonym: J-104871; UNII-6137X5QNJF; J104871; J 104871;
IUPAC/Chemical Name: (4R,5S)-5-(((2R,3R,E)-3-(benzo[d][1,3]dioxol-5-yl)-6-(benzo[d]oxazol-2-yl)hex-5-en-2-yl)(naphthalen-2-ylmethyl)carbamoyl)-1,3-dioxolane-2,2,4-tricarboxylic acid
InChi Key: CXDSZFRIMJUZKT-MRGWGSTCSA-N
InChi Code: InChI=1S/C38H32N2O12/c1-21(26(25-15-16-29-30(18-25)49-20-48-29)9-6-12-31-39-27-10-4-5-11-28(27)50-31)40(19-22-13-14-23-7-2-3-8-24(23)17-22)34(41)32-33(35(42)43)52-38(51-32,36(44)45)37(46)47/h2-8,10-18,21,26,32-33H,9,19-20H2,1H3,(H,42,43)(H,44,45)(H,46,47)/b12-6+/t21-,26+,32+,33-/m1/s1
SMILES Code: O=C(C1(C(O)=O)O[C@H](C(N([C@H](C)[C@@H](C2=CC=C(OCO3)C3=C2)C/C=C/C4=NC5=CC=CC=C5O4)CC6=CC=C7C=CC=CC7=C6)=O)[C@H](C(O)=O)O1)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 708.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Yonemoto M, Satoh T, Arakawa H, Suzuki-Takahashi I, Monden Y, Kodera T, Tanaka
K, Aoyama T, Iwasawa Y, Kamei T, Nishimura S, Tomimoto K. J-104,871, a novel
farnesyltransferase inhibitor, blocks Ras farnesylation in vivo in a farnesyl
pyrophosphate-competitive manner. Mol Pharmacol. 1998 Jul;54(1):1-7. PubMed PMID: