Dansyl-NECA

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MedKoo CAT#: 562657

CAS#: 219982-12-4

Description: Dansyl-NECA is a selective fluorescent adenosine A1 receptor agonist.


Price and Availability

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Pricing updated 2020-07-12. Prices are subject to change without notice.

Dansyl-NECA is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562657
Name: Dansyl-NECA
CAS#: 219982-12-4
Chemical Formula: C30H40N8O6S
Exact Mass: 640.2792
Molecular Weight: 640.76
Elemental Analysis: C, 56.23; H, 6.29; N, 17.49; O, 14.98; S, 5.00


Synonym: Dansyl-NECA; DansylNECA; Dansyl NECA;

IUPAC/Chemical Name: (2S,3S,4R,5R)-5-(6-((6-((5-(dimethylamino)naphthalene)-1-sulfonamido)hexyl)amino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide

InChi Key: CJDPJPUVKHWZHU-YRIIQKNPSA-N

InChi Code: InChI=1S/C30H40N8O6S/c1-4-31-29(41)26-24(39)25(40)30(44-26)38-18-35-23-27(33-17-34-28(23)38)32-15-7-5-6-8-16-36-45(42,43)22-14-10-11-19-20(22)12-9-13-21(19)37(2)3/h9-14,17-18,24-26,30,36,39-40H,4-8,15-16H2,1-3H3,(H,31,41)(H,32,33,34)/t24-,25+,26-,30+/m0/s1

SMILES Code: CN(C1=CC=CC2=C1C=CC=C2S(NCCCCCCNC3=NC=NC4=C3N=CN4[C@@H]5O[C@H](C(NCC)=O)[C@@H](O)[C@H]5O)(=O)=O)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Baker JG, Middleton R, Adams L, May LT, Briddon SJ, Kellam B, Hill SJ. Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands. Br J Pharmacol. 2010 Feb;159(4):772-86. doi: 10.1111/j.1476-5381.2009.00488.x. Epub 2010 Jan 26. PubMed PMID: 20105183; PubMed Central PMCID: PMC2829203.

2: Macchia M, Salvetti F, Barontini S, Calvani F, Gesi M, Hamdan M, Lucacchini A, Pellegrini A, Soldani P, Martini C. Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3223-8. PubMed PMID: 9873707.