Xylocholine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341486

CAS#: 669-50-1

Description: Xylocholine is a biochemical.


Price and Availability

Size
Price

Size
Price

Size
Price

Xylocholine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 341486
Name: Xylocholine
CAS#: 669-50-1
Chemical Formula: C13H22NO+
Exact Mass: 208.1696
Molecular Weight: 208.3245
Elemental Analysis: C, 74.95; H, 10.64; N, 6.72; O, 7.68


Synonym: Xylocholine;

IUPAC/Chemical Name: Ethanaminium, 2-(2,6-dimethylphenoxy)-N,N,N-trimethyl-

InChi Key: RXYWAURTGUPANZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H22NO/c1-11-7-6-8-12(2)13(11)15-10-9-14(3,4)5/h6-8H,9-10H2,1-5H3/q+1

SMILES Code: Cc1cccc(c1OCC[N+](C)(C)C)C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Orre M, Pennefather JN, Story ME, Haynes JM. The effects of P2 purinoceptor agonists on the isolated portal vein of the guinea pig. Eur J Pharmacol. 1996 Dec 5;316(2-3):229-36. PubMed PMID: 8982691.

2: Boura AL, Green AF. Noradrenergic neurone blocking agents. J Auton Pharmacol. 1981 Jun;1(3):255-67. PubMed PMID: 7040400.

3: Fielden R. The discovery of the noradrenergic neurone blocking action of TM10 (xylocholine). J Auton Pharmacol. 1981 Jun;1(3):251-4. PubMed PMID: 7040399.

4: Heitz DC, Brody MJ. Possible mechanism of histamine release during active vasodilatation. Am J Physiol. 1975 May;228(5):1351-7. PubMed PMID: 48345.

5: Prasad CM, Shah DS, Gulati OD. Some factors affecting the neuron blocking action of guanethidine, xylocholine, bretylium and debrisoquin. Jpn J Pharmacol. 1973 Dec;23(6):805-11. PubMed PMID: 4544694.

6: Hughes IE, Leak CM. Uptake of ( 14 C)xylocholine in mouse vas deferens after chemical sympathectomy. J Pharm Pharmacol. 1972 Sep;24(9):749-50. PubMed PMID: 4404086.

7: Dean HG, Hughes IE. Increased release of xylocholine (TM10) from guinea-pig vas deferens treated with amphetamine sulphate. J Pharm Pharmacol. 1972 Mar;24(3):183-8. PubMed PMID: 4402776.

8: Dean HG, Hughes IE. Effect of amphetamine on the uptake, release and effectiveness of xylocholine in the guinea-pig vas deferens. J Pharm Pharmacol. 1971 Aug;23(8):606-11. PubMed PMID: 4397745.

9: Coggon P, McPhail AT, Roe AM. Conformation of xylocholine. Nature. 1969 Dec 20;224(5225):1200-1. PubMed PMID: 5358339.

10: Schnizer W. [Effect of desipramine, cocaine and xylocholine on 5-hydroxytryptamine, adrenaline and vagus stimulation induced tonus decrease of smooth frog lung musculature]. Arzneimittelforschung. 1969 Apr;19(4):663-5. German. PubMed PMID: 5819171.

11: Clark ER, Jana M. The identification of the impurity responsible for the reported pressor activity of xylocholine. Br J Pharmacol Chemother. 1966 May;27(1):135-44. PubMed PMID: 5961461; PubMed Central PMCID: PMC1510797.

12: FIELDEN R, ROE AM, WILLEY GL. THE ADRENERGIC-NEURONE BLOCKING ACTION OF SOME COUMARAN COMPOUNDS. Br J Pharmacol Chemother. 1964 Dec;23:486-507. PubMed PMID: 14256809; PubMed Central PMCID: PMC1704011.

13: BHAGAT B. MODIFICATION OF THE EFFECTS OF GUANETHIDINE ON CARDIAC CATECHOL AMINES BY VARIOUS AGENTS. Br J Pharmacol Chemother. 1964 Apr;22:238-45. PubMed PMID: 14190459; PubMed Central PMCID: PMC1703988.

14: ROBERTS J, ITO R, REILLY J, CAIROLI VJ. INFLUENCE OF RESERPINE AND BETA TM 10 ON DIGITALIS-INDUCED VENTRICULAR ARRHYTHMIA. Circ Res. 1963 Aug;13:149-58. PubMed PMID: 14047640.

15: BURN JH, FROEDE H. The action of substances which block sympathetic postganglionic nervous transmission. Br J Pharmacol Chemother. 1963 Apr;20:378-87. PubMed PMID: 14017105; PubMed Central PMCID: PMC1703641.

16: WILLEY GL. Effect of antisympathomimetic drugs on the plasma concentrations of catechol amines. Br J Pharmacol Chemother. 1962 Dec;19:365-74. PubMed PMID: 14000807; PubMed Central PMCID: PMC1482210.

17: DAY MD. Effect of sympathomimetic amines on the blocking action of guanethidine, bretylium and xylocholine. Br J Pharmacol Chemother. 1962 Apr;18:421-39. PubMed PMID: 13884064; PubMed Central PMCID: PMC1482112.

18: AVIADO DM. Sympathetic nerve blocking drugs for the treatment of hypertension. TM-10, beta TM-10, bretylium and guanethidine. Am J Med Sci. 1961 May;241:650-61. PubMed PMID: 13685282.