Xylazine hydrochloride
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341476

CAS#: 23076-35-9 (HCl)

Description: Xylazine is an analogue of clonidine and an agonist at the α2 class of adrenergic receptor. It is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. Veterinarians also use xylazine as an emetic, especially in cats.


Price and Availability

Size
Price

5g
USD 450
100g
USD 1950
Size
Price

10g
USD 650
1kg
USD 5950
Size
Price

25g
USD 950

Xylazine hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 341476
Name: Xylazine hydrochloride
CAS#: 23076-35-9 (HCl)
Chemical Formula: C12H17ClN2S
Exact Mass: 256.0801
Molecular Weight: 256.792
Elemental Analysis: C, 56.13; H, 6.67; Cl, 13.80; N, 10.91; S, 12.48


Related CAS #: 23076-35-9 (HCl)   7361-61-7 (free base)    

Synonym: Xylazine hydrochloride; BAY-VA 1470; Anased; BAY 1470; BAY1470; BAY-1470; Primazine; Rometar; Sedomin; WH 7286; Xilazina

IUPAC/Chemical Name: 4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-, monohydrochloride

InChi Key: QYEFBJRXKKSABU-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H16N2S.ClH/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);1H

SMILES Code: CC1=C(NC2=NCCCS2)C(C)=CC=C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

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2: Lee C, Jones TA. Effects of Ketamine Compared with Urethane Anesthesia on Vestibular Sensory Evoked Potentials and Systemic Physiology in Mice. J Am Assoc Lab Anim Sci. 2018 Apr 25. doi: 10.30802/AALAS-JAALAS-17-000131. [Epub ahead of print] PubMed PMID: 29695313.

3: Stewart JL, Shipley CF, Ellerbrock RE, Schmidt L, Lima FS, Canisso IF. Physiological variations in reproductive and metabolic features of white-tailed deer (Odocoileus virginianus) bucks throughout the rutting season. Theriogenology. 2018 Apr 12;114:308-316. doi: 10.1016/j.theriogenology.2018.04.015. [Epub ahead of print] PubMed PMID: 29677634.

4: Ganguly S, Panetta JC, Roberts JK, Schuetz EG. Ketamine pharmacokinetics and pharmacodynamics are altered by Pgp and Bcrp efflux transporters in mice. Drug Metab Dispos. 2018 Apr 19. pii: dmd.117.078360. doi: 10.1124/dmd.117.078360. [Epub ahead of print] PubMed PMID: 29674491.

5: Tártaro RR, Jorge GL, Dianin AH, Escanhoela CAF, Boin IFSF. Ischemia With Preconditioning in Wistar Rats Maintains Mitochondrial Respiration, Even With Mild Hepatocellular Disturbance. Transplant Proc. 2018 Apr;50(3):848-852. doi: 10.1016/j.transproceed.2018.02.026. PubMed PMID: 29661451.

6: Williamson RH, Muller LL, Blair C. THE USE OF KETAMINE-XYLAZINE OR BUTORPHANOL-AZAPERONE-MEDETOMIDINE TO IMMOBILIZE AMERICAN BLACK BEARS ( URSUS AMERICANUS). J Wildl Dis. 2018 Apr 4. doi: 10.7589/2017-10-255. [Epub ahead of print] PubMed PMID: 29616881.

7: Sone K, Mori A, Sakamoto K, Nakahara T. GYY4137, an Extended-Release Hydrogen Sulfide Donor, Reduces NMDA-Induced Neuronal Injury in the Murine Retina. Biol Pharm Bull. 2018;41(4):657-660. doi: 10.1248/bpb.b17-01032. PubMed PMID: 29607941.

8: Celiker FB, Tumkaya L, Yilmaz A, Coskun ZO, Celiker M, Oghan F, Mercantepe T, Terzi S, Dursun E. Effects of gadolinium-based contrast agents on submandibular gland tissue in rats. Eur Arch Otorhinolaryngol. 2018 Mar 31. doi: 10.1007/s00405-018-4959-7. [Epub ahead of print] PubMed PMID: 29605866.

9: Bezdudnaya T, Hormigo KM, Marchenko V, Lane MA. Spontaneous respiratory plasticity following unilateral high cervical spinal cord injury in behaving rats. Exp Neurol. 2018 Mar 26;305:56-65. doi: 10.1016/j.expneurol.2018.03.014. [Epub ahead of print] PubMed PMID: 29596845.

10: Ida KK, Sauvage A, Gougnard A, Grauwels M, Serteyn D, Sandersen C. Use of Nasotracheal Intubation during General Anesthesia in Two Ponies with Tracheal Collapse. Front Vet Sci. 2018 Mar 13;5:42. doi: 10.3389/fvets.2018.00042. eCollection 2018. PubMed PMID: 29594157; PubMed Central PMCID: PMC5859214.

11: Haan JD, Hay Kraus BL, Sathe SR. A comparison of the effects of carbon dioxide and medical air for abdominal insufflation on respiratory parameters in xylazine-sedated sheep undergoing laparoscopic artificial insemination. N Z Vet J. 2018 Apr 25:1-5. doi: 10.1080/00480169.2018.1458661. [Epub ahead of print] PubMed PMID: 29591780.

12: Lucas Castillo JA, Gozalo-Marcilla M, Werneck Fonseca M, Possebon FS, da Rosa AC, de Araujo Aguiar AJ. Sedative and cardiorespiratory effects of low doses of xylazine with and without acepromazine in Nordestino donkeys. Equine Vet J. 2018 Mar 22. doi: 10.1111/evj.12835. [Epub ahead of print] PubMed PMID: 29569401.

13: Sahu S, Li R, Kadeyala PK, Liu S, Schachner M. The human natural killer-1 (HNK-1) glycan mimetic ursolic acid promotes functional recovery after spinal cord injury in mouse. J Nutr Biochem. 2018 Feb 9;55:219-228. doi: 10.1016/j.jnutbio.2018.01.016. [Epub ahead of print] PubMed PMID: 29567576.

14: Smith JS, Sheley M, Chigerwe M. ASPIRATION PNEUMONIA IN TWO TIBETAN YAK BULLS ( BOS GRUNNIENS) AS A COMPLICATION OF KETAMINE-XYLAZINE-BUTORPHANOL ANESTHESIA FOR RECUMBENT CASTRATION. J Zoo Wildl Med. 2018 Mar;49(1):242-246. doi: 10.1638/2016-0205R1.1. PubMed PMID: 29517446.

15: Hibbs CD, Barrett PM, Dees DD. Intraocular pressure reference intervals in eyes of clinically normal miniature donkeys (Equus africanus asinus). Vet Ophthalmol. 2018 Mar 8. doi: 10.1111/vop.12561. [Epub ahead of print] PubMed PMID: 29517162.

16: Seo EH, Song GY, Namgung JH, Oh CS, Lee SH, Kim SH. Receptor for activated C kinase 1 in rats with ischemia-reperfusion injury: intravenous versus inhalation anaesthetic agents. Int J Med Sci. 2018 Feb 12;15(4):352-358. doi: 10.7150/ijms.22591. eCollection 2018. PubMed PMID: 29511370; PubMed Central PMCID: PMC5835705.

17: Tighe RM, Birukova A, Yeager MJ, Reece SW, Gowdy KM. Euthanasia and Lavage Mediated Effects on Bronchoalveolar Measures of Lung Injury and Inflammation. Am J Respir Cell Mol Biol. 2018 Feb 26. doi: 10.1165/rcmb.2017-0357OC. [Epub ahead of print] PubMed PMID: 29481287.

18: Fulkerson CV, Lim CK, Baird AN, Weil AB, Heng HG, Gutierrez-Crespo B, Moore GE. Optimized computed tomography protocol for assessment of dentition in alpacas. Am J Vet Res. 2018 Mar;79(3):311-316. doi: 10.2460/ajvr.79.3.311. PubMed PMID: 29466047.

19: Tsukamoto A, Niino N, Sakamoto M, Ohtani R, Inomata T. The validity of anesthetic protocols for the surgical procedure of castration in rats. Exp Anim. 2018 Feb 14. doi: 10.1538/expanim.18-0003. [Epub ahead of print] PubMed PMID: 29445064.

20: Wittenberg-Voges L, Kästner SB, Raekallio M, Vainio OM, Rohn K, Hopster K. Effect of dexmedetomidine and xylazine followed by MK-467 on gastrointestinal microperfusion in anaesthetized horses. Vet Anaesth Analg. 2018 Mar;45(2):165-174. doi: 10.1016/j.vaa.2017.08.010. Epub 2017 Sep 15. PubMed PMID: 29439859.