XR 334

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341458

CAS#: 74720-35-7

Description: XR 334 is a biochemical.


Price and Availability

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Price

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XR 334 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 341458
Name: XR 334
CAS#: 74720-35-7
Chemical Formula: C19H16N2O3
Exact Mass: 320.1161
Molecular Weight: 320.348
Elemental Analysis: C, 71.24; H, 5.03; N, 8.74; O, 14.98


Synonym: XR-334; XR 334; XR334.

IUPAC/Chemical Name: 2,5-Piperazinedione, 3-((4-methoxyphenyl)methylene)-6-(phenylmethylene)-, (Z,Z)-

InChi Key: QMUALMJMQXNBIA-LSQIQBGYSA-N

InChi Code: InChI=1S/C19H16N2O3/c1-24-15-9-7-14(8-10-15)12-17-19(23)20-16(18(22)21-17)11-13-5-3-2-4-6-13/h2-12H,1H3,(H,20,23)(H,21,22)/b16-11-,17-12-

SMILES Code: O=C(/C(NC/1=O)=C/C2=CC=C(OC)C=C2)NC1=C/C3=CC=CC=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Ochoa JL, Bray WM, Lokey RS, Linington RG. Phenotype-Guided Natural Products Discovery Using Cytological Profiling. J Nat Prod. 2015 Sep 25;78(9):2242-8. doi: 10.1021/acs.jnatprod.5b00455. Epub 2015 Aug 21. PubMed PMID: 26292657.

2: Giessen TW, von Tesmar AM, Marahiel MA. Insights into the generation of structural diversity in a tRNA-dependent pathway for highly modified bioactive cyclic dipeptides. Chem Biol. 2013 Jun 20;20(6):828-38. doi: 10.1016/j.chembiol.2013.04.017. PubMed PMID: 23790493.

3: Bryans J, Charlton P, Chicarelli-Robinson I, Collins M, Faint R, Latham C, Shaw I, Trew S. Inhibition of plasminogen activator inhibitor-1 activity by two diketopiperazines, XR330 and XR334 produced by Streptomyces sp. J Antibiot (Tokyo). 1996 Oct;49(10):1014-21. PubMed PMID: 8968395.

4: Charlton PA, Faint RW, Bent F, Bryans J, Chicarelli-Robinson I, Mackie I, Machin S, Bevan P. Evaluation of a low molecular weight modulator of human plasminogen activator inhibitor-1 activity. Thromb Haemost. 1996 May;75(5):808-15. PubMed PMID: 8725728.