BS2G-d4 Deuterated Crosslinker

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MedKoo CAT#: 571630

CAS#: NONE

Description: BS2G-d4, or Bis(Sulfosuccinimidyl) 2,2,4,4-glutarate-d4, is a water soluble and cell membrane impermeable, protein crosslinker containing 4 deuterium atoms to provide a 4 dalton shift by mass spectrometry analysis.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 300 2 Weeks
50mg USD 750 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-04-07. Prices are subject to change without notice.

BS2G-d4, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571630
Name: BS2G-d4 Deuterated Crosslinker
CAS#: NONE
Chemical Formula: C13H8D4N2Na2O14S2
Exact Mass: 533.9776
Molecular Weight: 534.3629
Elemental Analysis: C, 29.22; H, 3.02; N, 5.24; Na, 8.60; O, 41.92; S, 12.00


Synonym: D4-BS2G, BS2G-d4

IUPAC/Chemical Name: Glutaric acid-2,2,4,4-d4 bis (3-sulfo-N-hydroxysuccinimide ester) disodium salt

InChi Key: JINCQYPCQMBZSX-SNSYAXNKSA-L

InChi Code: InChI=1S/C13H14N2O14S2.2Na/c16-8-4-6(30(22,23)24)12(20)14(8)28-10(18)2-1-3-11(19)29-15-9(17)5-7(13(15)21)31(25,26)27;;/h6-7H,1-5H2,(H,22,23,24)(H,25,26,27);;/q;2*+1/p-2/i2D2,3D2;;

SMILES Code: O=C(ON1C(CC(S(=O)([O-])=O)C1=O)=O)C([2H])([2H])CC([2H])([2H])C(ON2C(CC(S(=O)([O-])=O)C2=O)=O)=O.[Na+].[Na+]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Use heavy BS2G-d4 deuterated crosslinking reagent in combination with the non-deuterated analog BS2G-d0 (BS2G-d0, BS2G) for mass spec studies. Together BS2G-d0 and BS2G-d4 can be used for protein-protein interaction mapping using Liquid Chromatography–Mass Spectrometry (LCMS, LC/MS, LC-MS).


References

1: Haladová K, Mrázek H, Ječmen T, Halada P, Man P, Novák P, Chmelík J, Obšil T, Šulc M. The combination of hydrogen/deuterium exchange or chemical cross-linking techniques with mass spectrometry: mapping of human 14-3-3ζ homodimer interface. J Struct Biol. 2012 Jul;179(1):10-7. doi: 10.1016/j.jsb.2012.04.016. Epub 2012 May 2. PubMed PMID: 22580067.