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MedKoo CAT#: 584415

CAS#: 85505-64-2

Description: Vapiprost is a thromboxane receptor antagonist and prostaglandin receptor antagonist.

Price and Availability

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Pricing updated 2020-09-27. Prices are subject to change without notice.

Vapiprost is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 584415
Name: Vapiprost
CAS#: 85505-64-2
Chemical Formula: C30H39NO4
Exact Mass: 477.2879
Molecular Weight: 477.645
Elemental Analysis: C, 75.44; H, 8.23; N, 2.93; O, 13.40

Synonym: Vapiprost; GR 32191; GR32191; GR-32191

IUPAC/Chemical Name: 4-Heptenoic acid, 7-(5-((1,1'-biphenyl)-4-ylmethoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl)-, (1R-(1alpha(Z),2beta,3beta,5alpha))-


InChi Code: InChI=1S/C30H39NO4/c32-27-21-28(35-22-23-15-17-25(18-16-23)24-11-5-3-6-12-24)26(13-7-1-2-8-14-29(33)34)30(27)31-19-9-4-10-20-31/h1-3,5-6,11-12,15-18,26-28,30,32H,4,7-10,13-14,19-22H2,(H,33,34)/b2-1-/t26-,27-,28-,30+/m0/s1

SMILES Code: O=C(O)CC/C=C\CC[C@@H]1[C@@H](N2CCCCC2)[C@@H](O)C[C@@H]1OCC3=CC=C(C4=CC=CC=C4)C=C3

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


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2: Nishiyama H, Umemura K, Saniabadi AR, Takiguchi Y, Uematsu T, Nakashima M. Enhancement of thrombolytic efficacy of tissue-type plasminogen activator by adjuvants in the guinea pig thrombosis model. Eur J Pharmacol. 1994 Oct 24;264(2):191-8. PubMed PMID: 7851482.

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5: Idris-Khodja N, Auger C, Koch E, Schini-Kerth VB. Crataegus special extract WS(®)1442 prevents aging-related endothelial dysfunction. Phytomedicine. 2012 Jun 15;19(8-9):699-706. doi: 10.1016/j.phymed.2012.04.005. Epub 2012 May 22. PubMed PMID: 22621780.

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7: Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Itomine T, Uza M, Toyama F, Higuchi M. Inhibitory effect of vapiprost on contractile responses of isolated dog renal arteries to thromboxane A2 analogue, U46619. Gen Pharmacol. 1994 Jul;25(4):617-22. PubMed PMID: 7958719.

8: Exner HJ, Schlicker E. Prostanoid receptors of the EP3 subtype mediate the inhibitory effect of prostaglandin E2 on noradrenaline release in the mouse brain cortex. Naunyn Schmiedebergs Arch Pharmacol. 1995 Jan;351(1):46-52. PubMed PMID: 7715741.

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10: Umemura K, Kawai H, Ishihara H, Nakashima M. Inhibitory effect of clopidogrel, vapiprost and argatroban on the middle cerebral artery thrombosis in the rat. Jpn J Pharmacol. 1995 Mar;67(3):253-8. PubMed PMID: 7630043.

11: Tsui SS, Kirshbom PM, Davies MJ, Jacobs MT, Kern FH, Gaynor JW, Greeley WJ, Ungerleider RM. Thromboxane A2-receptor blockade improves cerebral protection for deep hypothermic circulatory arrest. Eur J Cardiothorac Surg. 1997 Aug;12(2):228-35. PubMed PMID: 9288512.

12: Ohashi K, Aso R. Influence of age on the pharmacokinetics of vapiprost, a thromboxane A2 receptor antagonist, and platelet aggregation: comparison of pharmacokinetics by routine approach and population pharmacokinetics. Int J Clin Pharmacol Res. 2001;21(2):85-94. PubMed PMID: 11824652.

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15: Lundell A, Bergqvist D, Leide S, Lindblad B, Ljungberg J. The effect of a thromboxane receptor antagonist on acute ePTFE arterial graft thrombogenicity--an experimental study in sheep. Eur J Vasc Surg. 1991 Jun;5(3):321-6. PubMed PMID: 1830856.

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17: Takiguchi Y, Wada K, Nakashima M. Comparison of the inhibitory effects of the TXA2 receptor antagonist, vapiprost, and other antiplatelet drugs on arterial thrombosis in rats: possible role of TXA2. Thromb Haemost. 1992 Oct 5;68(4):460-3. PubMed PMID: 1448780.

18: Matsuno H, Uematsu T, Umemura K, Takiguchi Y, Wada K, Nakashima M. Effects of vapiprost, a novel thromboxane receptor antagonist, on thrombus formation and vascular patency after thrombolysis by tissue-type plasminogen activator. Br J Pharmacol. 1992 Jul;106(3):533-8. PubMed PMID: 1387025; PubMed Central PMCID: PMC1907568.

19: Takiguchi Y, Asai F, Wada K, Nakashima M. Comparison of antithrombotic effects of GPIIb-IIIa receptor antagonist and TXA2 receptor antagonist in the guinea-pig thrombosis model: possible role of TXA2 in reocclusion after thrombolysis. Thromb Haemost. 1995 Apr;73(4):683-8. PubMed PMID: 7495079.

20: Kawano KI, Hokamura K, Kondo K, Ikeda Y, Suzuki Y, Umemura K. Thromboxane A(2) synthase inhibitor enhanced antithrombotic efficacy of GPIIb-IIIa receptor antagonist without increasing bleeding. Eur J Pharmacol. 2001 Apr 13;417(3):217-22. PubMed PMID: 11334853.