WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206966
CAS#: 2201065-84-9
Description: AGI-25696 is a MATA2 inhibitor that are useful as therapeutic agents for treating malignancies. AGI-25696 showed in vivo activity in MTAP null tumors. Note: The correct structure of AGI-25696 is CAS#2201065-84-9. Many vendors mistakenly listed CAS#2201066-35-3 as its AGI25696. J. Med. Chem. 2021, 64, 8, 4430–4449 published AGI25696 structure (it is CAS#2201065-84-9).
MedKoo Cat#: 206966
Name: AGI25696
CAS#: 2201065-84-9
Chemical Formula: C28H20N4O
Exact Mass: 428.1637
Molecular Weight: 428.49
Elemental Analysis: C, 78.49; H, 4.70; N, 13.08; O, 3.73
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Related CAS #: 2201066-35-3 (de-methyl) 2201065-84-9
Synonym: AGI-25696; AGI 25696; AGI25696.
IUPAC/Chemical Name: 5-methyl-2,3-diphenyl-6-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
InChi Key: ZMZOMWGRJGQLDW-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H20N4O/c1-18-24(22-14-15-23-21(17-22)13-8-16-29-23)28(33)32-27(30-18)25(19-9-4-2-5-10-19)26(31-32)20-11-6-3-7-12-20/h2-17,30H,1H3
SMILES Code: O=C1C(C2=CC=C3N=CC=CC3=C2)=C(C)NC4=C(C5=CC=CC=C5)C(C6=CC=CC=C6)=NN14
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 428.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as inhibitors of cellular metabolic processes and their preparation
By Konteatis, Zenon D.; Sui, Zhihua; Travins, Jeremy M.; Ye, Zhixiong
From U.S. Pat. Appl. Publ. (2018), US 20180079753 A1 20180322. | Language: English, Database: CAPLUS
2. Preparation of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as methionine adenosyltransferase 2A inhibitors for treatment of cancer
By Konteatis, Zenon D.; Sui, Zhihua; Travins, Jeremy M.; Ye, Zhixiong
From PCT Int. Appl. (2018), WO 2018045071 A1 20180308. | Language: English, Database: CAPLUS
