WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562571

CAS#: 1219589-99-7

Description: 3-HIB is a paracrine regulator of trans-endothelial fatty acid transport.

Chemical Structure

CAS# 1219589-99-7

Theoretical Analysis

MedKoo Cat#: 562571
Name: 3-HIB
CAS#: 1219589-99-7
Chemical Formula: C4H7NaO3
Exact Mass:
Molecular Weight: 126.08
Elemental Analysis: C, 38.10; H, 5.60; Na, 18.23; O, 38.07

Price and Availability

Size Price Availability Quantity
250.0mg USD 300.0 2 Weeks
1.0g USD 680.0 2 Weeks
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Synonym: 3-HIB; 3 HIB; 3HIB;

IUPAC/Chemical Name: Sodium 3-Hydroxyisobutyrate


InChi Code: InChI=1S/C4H8O3.Na/c1-3(2-5)4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1

SMILES Code: CC(CO)C([O-])=O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 126.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Mardinoglu A, Gogg S, Lotta LA, Stančáková A, Nerstedt A, Boren J, Blüher M, Ferrannini E, Langenberg C, Wareham NJ, Laakso M, Smith U. Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes. EBioMedicine. 2018 Jan;27:151-155. doi: 10.1016/j.ebiom.2017.12.008. Epub 2017 Dec 7. PubMed PMID: 29246479; PubMed Central PMCID: PMC5828558.

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4: Harris LLS, Smith GI, Patterson BW, Ramaswamy RS, Okunade AL, Kelly SC, Porter LC, Klein S, Yoshino J, Mittendorfer B. Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism Are Associated With Protein Ingestion-Induced Insulin Resistance. Diabetes. 2017 Jul;66(7):1871-1878. doi: 10.2337/db16-1475. Epub 2017 May 4. PubMed PMID: 28473464; PubMed Central PMCID: PMC5482083.

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6: Centers for Disease Control and Prevention (CDC). Changes in measurement of Haemophilus influenzae serotype b (Hib) vaccination coverage --- National Immunization Survey, United States, 2009. MMWR Morb Mortal Wkly Rep. 2010 Aug 27;59(33):1069-72. PubMed PMID: 20798669.

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12: Crisma M, Valle G, Bonora GM, Toniolo C, Cavicchioni G. The beta-bend ribbon spiral. Synthesis and conformational analysis in solution and in the crystal state of depsipeptides containing alpha-hydroxyisobutyric acid. Int J Pept Protein Res. 1993 Jun;41(6):553-60. PubMed PMID: 8349413.

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250.0mg / USD 300.0