CAY10404
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527888

CAS#: 340267-36-9

Description: CAY10404 is one of the most selective inhibitors of COX-2 over COX-1.


Chemical Structure

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CAY10404
CAS# 340267-36-9

Theoretical Analysis

MedKoo Cat#: 527888
Name: CAY10404
CAS#: 340267-36-9
Chemical Formula: C17H12F3NO3S
Exact Mass: 367.049
Molecular Weight: 367.3422
Elemental Analysis: C, 55.58; H, 3.29; F, 15.52; N, 3.81; O, 13.07; S, 8.73

Price and Availability

Size Price Availability Quantity
50.0mg USD 350.0 2 Weeks
100.0mg USD 550.0 2 Weeks
200.0mg USD 950.0 2 Weeks
500.0mg USD 1850.0 2 Weeks
1.0g USD 2950.0 2 Weeks
2.0g USD 5250.0 2 Weeks
5.0g USD 7650.0 2 Weeks
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Synonym: CAY 10404; CAY-10404; CAY10404

IUPAC/Chemical Name: 3-[4-(Methylsulfonyl)phenyl]-4-phenyl-5-(trifluoromethyl)-isoxazole

InChi Key: KKBWWVXRKULXHF-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H12F3NO3S/c1-25(22,23)13-9-7-12(8-10-13)15-14(11-5-3-2-4-6-11)16(24-21-15)17(18,19)20/h2-10H,1H3

SMILES Code: FC(C1=C(C2=CC=CC=C2)C(C3=CC=C(S(=O)(C)=O)C=C3)=NO1)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100.0 272.23

Preparing Stock Solutions

The following data is based on the product molecular weight 367.3422 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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7: Tajima T, Murata T, Aritake K, Urade Y, Michishita M, Matsuoka T, Narumiya S, Ozaki H, Hori M. EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals. Am J Physiol Gastrointest Liver Physiol. 2012 Mar 1;302(5):G524-34. doi: 10.1152/ajpgi.00264.2011. Epub 2011 Dec 8. PubMed PMID: 22159280; PubMed Central PMCID: PMC3311437.

8: Iwanaga K, Okada M, Murata T, Hori M, Ozaki H. Prostaglandin E2 promotes wound-induced migration of intestinal subepithelial myofibroblasts via EP2, EP3, and EP4 prostanoid receptor activation. J Pharmacol Exp Ther. 2012 Mar;340(3):604-11. doi: 10.1124/jpet.111.189845. Epub 2011 Dec 2. PubMed PMID: 22138372.

9: Abu-Ghefreh AA, Masocha W. Enhancement of antinociception by coadministration of minocycline and a non-steroidal anti-inflammatory drug indomethacin in naïve mice and murine models of LPS-induced thermal hyperalgesia and monoarthritis. BMC Musculoskelet Disord. 2010 Dec 1;11:276. doi: 10.1186/1471-2474-11-276. PubMed PMID: 21122103; PubMed Central PMCID: PMC3009629.

10: Aljofan M, Ding H. High glucose increases expression of cyclooxygenase-2, increases oxidative stress and decreases the generation of nitric oxide in mouse microvessel endothelial cells. J Cell Physiol. 2010 Mar;222(3):669-75. doi: 10.1002/jcp.21986. PubMed PMID: 19950211.

11: Cho Y, Park MJ, Park M, Min SS, Yee J, Kim C, Han MS, Han SH. Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells. Respirology. 2009 Aug;14(6):850-8. doi: 10.1111/j.1440-1843.2009.01563.x. PubMed PMID: 19703066.

12: Moody TW, Switzer C, Santana-Flores W, Ridnour LA, Berna M, Thill M, Jensen RT, Sparatore A, Del Soldato P, Yeh GC, Roberts DD, Giaccone G, Wink DA. Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells. Lung Cancer. 2010 May;68(2):154-60. doi: 10.1016/j.lungcan.2009.06.012. Epub 2009 Jul 23. PubMed PMID: 19628293; PubMed Central PMCID: PMC3835159.

13: Rastogi P, Young DM, McHowat J. Tryptase activates calcium-independent phospholipase A2 and releases PGE2 in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L925-32. doi: 10.1152/ajplung.90230.2008. Epub 2008 Sep 12. PubMed PMID: 18790994; PubMed Central PMCID: PMC2584891.

14: Hoshino T, Tabuchi K, Hirose Y, Uemaetomari I, Murashita H, Tobita T, Hara A. The non-steroidal anti-inflammatory drugs protect mouse cochlea against acoustic injury. Tohoku J Exp Med. 2008 Sep;216(1):53-9. PubMed PMID: 18719338.

15: Rajagopalan G, Asmann YW, Lytle AK, Tilahun AY, Theuer JE, Smart MK, Patel R, David CS. Cyclooxygenase 2 pathway and its therapeutic inhibition in superantigen-induced toxic shock. Shock. 2008 Dec;30(6):721-8. doi: 10.1097/SHK.0b013e31817048f7. PubMed PMID: 18496243.

16: Tajima T, Murata T, Aritake K, Urade Y, Hirai H, Nakamura M, Ozaki H, Hori M. Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2). J Pharmacol Exp Ther. 2008 Aug;326(2):493-501. doi: 10.1124/jpet.108.137992. Epub 2008 May 20. PubMed PMID: 18492946.

17: Cusimano A, Foderà D, D'Alessandro N, Lampiasi N, Azzolina A, Montalto G, Cervello M. Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway. Cancer Biol Ther. 2007 Sep;6(9):1461-8. Epub 2007 Jun 26. PubMed PMID: 18424914.

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19: Ryan EP, Bushnell TP, Friedman AE, Rahman I, Phipps RP. Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells. Cancer Immunol Immunother. 2008 Mar;57(3):347-58. Epub 2007 Aug 1. PubMed PMID: 17668203.

20: Cao J, Kitazawa T, Takehana K, Taneike T. Endogenous prostaglandins regulate spontaneous contractile activity of uterine strips isolated from non-pregnant pigs. Prostaglandins Other Lipid Mediat. 2006 Dec;81(3-4):93-105. Epub 2006 Sep 25. PubMed PMID: 17085318.

CAY10404

50.0mg / USD 350.0