BX430
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MedKoo CAT#: 562533

CAS#: 688309-70-8

Description: BX430 is a selective allosteric antagonist of human P2X4 receptor channels.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 230 2 Weeks
25mg USD 580 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-04-09. Prices are subject to change without notice.

BX430, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562533
Name: BX430
CAS#: 688309-70-8
Chemical Formula: C15H15Br2N3O
Exact Mass: 410.9582
Molecular Weight: 413.11
Elemental Analysis: C, 43.61; H, 3.66; Br, 38.68; N, 10.17; O, 3.87


Synonym: BX430; BX-430; BX 430;

IUPAC/Chemical Name: N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-3-pyridinyl-urea

InChi Key: JFNKIJKRXKPQCC-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21)

SMILES Code: O=C(NC1=CC=CN=C1)NC2=C(Br)C=C(C(C)C)C=C2Br


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Layhadi JA, Turner J, Crossman D, Fountain SJ. ATP Evokes Ca(2+) Responses and CXCL5 Secretion via P2X(4) Receptor Activation in Human Monocyte-Derived Macrophages. J Immunol. 2018 Feb 1;200(3):1159-1168. doi: 10.4049/jimmunol.1700965. Epub 2017 Dec 18. PubMed PMID: 29255078; PubMed Central PMCID: PMC5784824.

2: Stokes L, Layhadi JA, Bibic L, Dhuna K, Fountain SJ. P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology. Front Pharmacol. 2017 May 23;8:291. doi: 10.3389/fphar.2017.00291. eCollection 2017. Review. PubMed PMID: 28588493; PubMed Central PMCID: PMC5441391.

3: Ase AR, Honson NS, Zaghdane H, Pfeifer TA, Séguéla P. Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels. Mol Pharmacol. 2015 Apr;87(4):606-16. doi: 10.1124/mol.114.096222. Epub 2015 Jan 16. PubMed PMID: 25597706.