BX430
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562533

CAS#: 688309-70-8

Description: BX430 is a selective allosteric antagonist of human P2X4 receptor channels.

Chemical Structure

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BX430
CAS# 688309-70-8
Instruction

Theoretical Analysis

MedKoo Cat#: 562533
Name: BX430
CAS#: 688309-70-8
Chemical Formula: C15H15Br2N3O
Exact Mass: 410.96
Molecular Weight: 413.110
Elemental Analysis: C, 43.61; H, 3.66; Br, 38.68; N, 10.17; O, 3.87

Price and Availability

Size Price Availability Quantity
5mg USD 230
25mg USD 580
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Synonym: BX430; BX-430; BX 430;

IUPAC/Chemical Name: N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-3-pyridinyl-urea

InChi Key: JFNKIJKRXKPQCC-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21)

SMILES Code: O=C(NC1=CC=CN=C1)NC2=C(Br)C=C(C(C)C)C=C2Br

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 413.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Layhadi JA, Turner J, Crossman D, Fountain SJ. ATP Evokes Ca(2+) Responses and CXCL5 Secretion via P2X(4) Receptor Activation in Human Monocyte-Derived Macrophages. J Immunol. 2018 Feb 1;200(3):1159-1168. doi: 10.4049/jimmunol.1700965. Epub 2017 Dec 18. PubMed PMID: 29255078; PubMed Central PMCID: PMC5784824.

2: Stokes L, Layhadi JA, Bibic L, Dhuna K, Fountain SJ. P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology. Front Pharmacol. 2017 May 23;8:291. doi: 10.3389/fphar.2017.00291. eCollection 2017. Review. PubMed PMID: 28588493; PubMed Central PMCID: PMC5441391.

3: Ase AR, Honson NS, Zaghdane H, Pfeifer TA, Séguéla P. Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels. Mol Pharmacol. 2015 Apr;87(4):606-16. doi: 10.1124/mol.114.096222. Epub 2015 Jan 16. PubMed PMID: 25597706.