DBIBB
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562532

CAS#: 1569309-92-7

Description: DBIBB is a LPA2 receptor-specific nonlipid agonist. It acts by mitigating cell and tissue injury in vitro and in vivo, protecting cells from radiation injury and enhancing DNA repair via LPA2.

Chemical Structure

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DBIBB
CAS# 1569309-92-7
Instruction

Theoretical Analysis

MedKoo Cat#: 562532
Name: DBIBB
CAS#: 1569309-92-7
Chemical Formula: C23H20N2O6S
Exact Mass: 452.10
Molecular Weight: 452.480
Elemental Analysis: C, 61.05; H, 4.46; N, 6.19; O, 21.22; S, 7.09

Price and Availability

Size Price Availability Quantity
5mg USD 425 2 Weeks
10mg USD 750 2 Weeks
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Synonym: DBIBB;

IUPAC/Chemical Name: 2-[4-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-butylsulfamoyl]-benzoic acid

InChi Key: POLJNARIJSROOS-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H20N2O6S/c26-21-17-10-5-7-15-8-6-11-18(20(15)17)22(27)25(21)14-4-3-13-24-32(30,31)19-12-2-1-9-16(19)23(28)29/h1-2,5-12,24H,3-4,13-14H2,(H,28,29)

SMILES Code: O=C(O)C1=CC=CC=C1S(=O)(NCCCCN(C(C2=CC=CC3=CC=CC4=C23)=O)C4=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 452.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Lin, F.T., Lai, Y.J., Makarova, N., et al. The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival. The Journal of Biological Chemisty 282(52), 37759-37769 (2007).

2. Patil, R., Szabó, E., Fells, J.I., et al. Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist. Chemistry & Biology 22, 206-216 (2015).