WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562516

CAS#: 1115177-19-9

Description: UCD38B HCl is a cell permeable inhibitor of intracellular uPA (urokinase plasminogen activator). It acts by killing proliferative and non-proliferative high grade glioma cells by programmed necrosis.

Chemical Structure

CAS# 1115177-19-9

Theoretical Analysis

MedKoo Cat#: 562516
Name: UCD38B HCl
CAS#: 1115177-19-9
Chemical Formula: C15H17Cl2N7O3
Exact Mass:
Molecular Weight: 414.24
Elemental Analysis: C, 43.49; H, 4.14; Cl, 17.12; N, 23.67; O, 11.59

Price and Availability

Size Price Availability Quantity
5.0mg USD 260.0 2 Weeks
25.0mg USD 660.0 2 Weeks
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Synonym: UCD38B HCl; UCD-38-B HCl; UCD 38 B HCl; UCD-38-B Hydrochloride; UCD 38 B hydrochloride; UCD38B hydrochloride; 5-Benzylglycinyl-amiloride hydrochloride;

IUPAC/Chemical Name: N-[6-Amino-5-[[(aminoiminomethyl)-amino]carbonyl]-3-chloro-2-pyrazinyl]-glycine phenylmethyl ester hydrochloride


InChi Code: InChI=1S/C15H16ClN7O3.ClH/c16-11-13(22-12(17)10(21-11)14(25)23-15(18)19)20-6-9(24)26-7-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H3,17,20,22)(H4,18,19,23,25);1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 414.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Gorin FA, Pasupuleti N, Mahajan D, Dugar S. Killing Glioma 'Stem-like' Cells via Drug-Induced Relocation of Endosomal Urokinase Proteins. Anticancer Agents Med Chem. 2017;17(1):40-47. Review. PubMed PMID: 27357540.

2: Pasupuleti N, Grodzki AC, Gorin F. Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death. Mol Pharmacol. 2015 Apr;87(4):683-96. doi: 10.1124/mol.114.096602. Epub 2015 Jan 29. PubMed PMID: 25634671; PubMed Central PMCID: PMC4366798.

3: Leon LJ, Pasupuleti N, Gorin F, Carraway KL 3rd. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One. 2013 Apr 30;8(4):e63038. doi: 10.1371/journal.pone.0063038. Print 2013. PubMed PMID: 23646172; PubMed Central PMCID: PMC3639988.

4: Pasupuleti N, Leon L, Carraway KL 3rd, Gorin F. 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013 Mar;344(3):600-15. doi: 10.1124/jpet.112.200519. Epub 2012 Dec 14. PubMed PMID: 23241369; PubMed Central PMCID: PMC3583503.