WAY100635 Maleate
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527881

CAS#: 1092679-51-0

Description: WAY100635 Maleate is a potent, silent antagonist of serotonin 5-HT1A receptors.


Chemical Structure

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WAY100635 Maleate
CAS# 1092679-51-0

Theoretical Analysis

MedKoo Cat#: 527881
Name: WAY100635 Maleate
CAS#: 1092679-51-0
Chemical Formula: C29H38N4O6
Exact Mass: 538.2791
Molecular Weight: 538.645
Elemental Analysis: C, 64.67; H, 7.11; N, 10.40; O, 17.82

Price and Availability

Size Price Availability Quantity
5.0mg USD 200.0 2 Weeks
10.0mg USD 350.0 2 Weeks
50.0mg USD 850.0 2 Weeks
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Synonym: WAY 100635; WAY-100635; WAY100635 Maleate

IUPAC/Chemical Name: N-(2-(4-(2-Methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide Maleate

InChi Key: XIGAHNVCEFUYOV-BTJKTKAUSA-N

InChi Code: InChI=1S/C25H34N4O2.C4H4O4/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21;5-3(6)1-2-4(7)8/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES Code: O=C(C1CCCCC1)N(CCN2CCN(C3=CC=CC=C3OC)CC2)C4=NC=CC=C4.O=C(O)/C=C\C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 538.645 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sestile CC, Maraschin JC, Rangel MP, Santana RG, Zangrossi H Jr, Graeff FG, Audi EA. B2-kinin receptors in the dorsal periaqueductal gray are implicated in the panicolytic-like effect of opiorphin. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):493-498. doi: 10.1016/j.pnpbp.2017.08.003. Epub 2017 Aug 7. PubMed PMID: 28797641.

2: Pérez-Ortega G, Angeles-López GE, Argueta-Villamar A, González-Trujano ME. Preclinical evidence of the anxiolytic and sedative-like activities of Tagetes erecta L. reinforces its ethnobotanical approach. Biomed Pharmacother. 2017 Sep;93:383-390. doi: 10.1016/j.biopha.2017.06.064. Epub 2017 Jun 24. PubMed PMID: 28654794.

3: Grasso C, Li Volsi G, Barresi M. Serotonin modifies the spontaneous spiking activity of gracile nucleus neurons in rats: role of 5-HT1A and 5-HT2 receptors. Arch Ital Biol. 2016 Jun 1;154(2-3):39-49. doi: 10.4449/aib.v154i2/3.3430. PubMed PMID: 27918061.

4: Woźniak M, Gołembiowska K, Noworyta-Sokołowska K, Acher F, Cieślik P, Kusek M, Tokarski K, Pilc A, Wierońska JM. Neurochemical and behavioral studies on the 5-HT(1A)-dependent antipsychotic action of the mGlu(4) receptor agonist LSP4-2022. Neuropharmacology. 2017 Mar 15;115:149-165. doi: 10.1016/j.neuropharm.2016.06.025. Epub 2016 Jul 25. PubMed PMID: 27465045.

5: Pérez-Ortega G, González-Trujano ME, Ángeles-López GE, Brindis F, Vibrans H, Reyes-Chilpa R. Tagetes lucida Cav.: Ethnobotany, phytochemistry and pharmacology of its tranquilizing properties. J Ethnopharmacol. 2016 Apr 2;181:221-8. doi: 10.1016/j.jep.2016.01.040. Epub 2016 Feb 9. PubMed PMID: 26873624.

6: Wierońska JM, Sławińska A, Łasoń-Tyburkiewicz M, Gruca P, Papp M, Zorn SH, Doller D, Kłeczek N, Noworyta-Sokołowska K, Gołembiowska K, Pilc A. The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies. Psychopharmacology (Berl). 2015 Jan;232(1):259-73. doi: 10.1007/s00213-014-3657-4. Epub 2014 Jul 11. PubMed PMID: 25012236; PubMed Central PMCID: PMC4281359.

7: Maeda K, Lerdrup L, Sugino H, Akazawa H, Amada N, McQuade RD, Stensbøl TB, Bundgaard C, Arnt J, Kikuchi T. Brexpiprazole II: antipsychotic-like and procognitive effects of a novel serotonin-dopamine activity modulator. J Pharmacol Exp Ther. 2014 Sep;350(3):605-14. doi: 10.1124/jpet.114.213819. Epub 2014 Jun 19. Erratum in: J Pharmacol Exp Ther. 2014 Dec;351(3):686-7. PubMed PMID: 24947464.

8: Conti MM, Ostock CY, Lindenbach D, Goldenberg AA, Kampton E, Dell'isola R, Katzman AC, Bishop C. Effects of prolonged selective serotonin reuptake inhibition on the development and expression of L-DOPA-induced dyskinesia in hemi-parkinsonian rats. Neuropharmacology. 2014 Feb;77:1-8. doi: 10.1016/j.neuropharm.2013.09.017. Epub 2013 Sep 22. PubMed PMID: 24067924; PubMed Central PMCID: PMC3865178.

9: Ohmura Y, Kumamoto H, Tsutsui-Kimura I, Minami M, Izumi T, Yoshida T, Yoshioka M. Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor. J Pharmacol Sci. 2013;122(2):84-92. Epub 2013 May 24. PubMed PMID: 23707971.

10: Wierońska JM, Acher FC, Sławińska A, Gruca P, Lasoń-Tyburkiewicz M, Papp M, Pilc A. The antipsychotic-like effects of the mGlu group III orthosteric agonist, LSP1-2111, involves 5-HT₁A signalling. Psychopharmacology (Berl). 2013 Jun;227(4):711-25. doi: 10.1007/s00213-013-3005-0. Epub 2013 Mar 10. PubMed PMID: 23474845; PubMed Central PMCID: PMC3663209.

11: Bradford AM, Savage KM, Jones DN, Kalinichev M. Validation and pharmacological characterisation of MK-801-induced locomotor hyperactivity in BALB/C mice as an assay for detection of novel antipsychotics. Psychopharmacology (Berl). 2010 Oct;212(2):155-70. doi: 10.1007/s00213-010-1938-0. Epub 2010 Jul 31. PubMed PMID: 20676613.

12: Steffens SM, Beckman D, Faria MS, Marino-Neto J, Paschoalini MA. WAY100635 blocks the hypophagia induced by 8-OH-DPAT in the hypothalamic nuclei. Physiol Behav. 2010 Apr 19;99(5):632-7. doi: 10.1016/j.physbeh.2010.01.024. Epub 2010 Feb 6. PubMed PMID: 20138904.

13: Mato S, Vidal R, Castro E, Díaz A, Pazos A, Valdizán EM. Long-term fluoxetine treatment modulates cannabinoid type 1 receptor-mediated inhibition of adenylyl cyclase in the rat prefrontal cortex through 5-hydroxytryptamine 1A receptor-dependent mechanisms. Mol Pharmacol. 2010 Mar;77(3):424-34. doi: 10.1124/mol.109.060079. Epub 2009 Dec 7. PubMed PMID: 19995940.

14: Labonte B, Bambico FR, Gobbi G. Potentiation of excitatory serotonergic responses by MK-801 in the medial prefrontal cortex. Naunyn Schmiedebergs Arch Pharmacol. 2009 Nov;380(5):383-97. doi: 10.1007/s00210-009-0446-4. PubMed PMID: 19727675.

15: Perez-García G, Meneses A. Ex vivo study of 5-HT(1A) and 5-HT(7) receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia. Behav Brain Res. 2008 Dec 16;195(1):139-46. doi: 10.1016/j.bbr.2008.07.033. Epub 2008 Aug 3. PubMed PMID: 18723050.

16: Levita L, Hammack SE, Mania I, Li XY, Davis M, Rainnie DG. 5-hydroxytryptamine1A-like receptor activation in the bed nucleus of the stria terminalis: electrophysiological and behavioral studies. Neuroscience. 2004;128(3):583-96. PubMed PMID: 15381287.

17: Sakaue M, Ago Y, Baba A, Matsuda T. The 5-HT1A receptor agonist MKC-242 reverses isolation rearing-induced deficits of prepulse inhibition in mice. Psychopharmacology (Berl). 2003 Oct;170(1):73-9. Epub 2003 May 27. PubMed PMID: 12768276.

18: Tolu P, Masi F, Leggio B, Scheggi S, Tagliamonte A, De Montis MG, Gambarana C. Effects of long-term acetyl-L-carnitine administration in rats: I. increased dopamine output in mesocorticolimbic areas and protection toward acute stress exposure. Neuropsychopharmacology. 2002 Sep;27(3):410-20. PubMed PMID: 12225698.

19: Liang KC. Pre- or post-training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5-HT1A receptors. Eur J Neurosci. 1999 May;11(5):1491-500. PubMed PMID: 10215901.