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MedKoo CAT#: 341309

CAS#: 2798-25-6

Description: Bellidifolin is a biochemical.

Price and Availability

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Pricing updated 2020-10-19. Prices are subject to change without notice.

Bellidifolin is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 341309
Name: Bellidifolin
CAS#: 2798-25-6
Chemical Formula: C14H10O6
Exact Mass: 274.0477
Molecular Weight: 274.228
Elemental Analysis: C, 61.32; H, 3.68; O, 35.01

Synonym: Bellidifolin; BRN 0288441; CCRIS 5471; CCRIS-5471; CCRIS5471;

IUPAC/Chemical Name: Xanthen-9-one, 3-methoxy-1,5,8-trihydroxy-


InChi Code: InChI=1S/C14H10O6/c1-19-6-4-9(17)11-10(5-6)20-14-8(16)3-2-7(15)12(14)13(11)18/h2-5,15-17H,1H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: You RR, Chen XQ, He DD, Huang CG, Jin Y, Qian SH, Ju JM, Fan JT. [Chemical constituents from petroleum ether fraction of Swertia chirayita and their activities in vitro]. Zhongguo Zhong Yao Za Zhi. 2017 Oct;42(19):3764-3769. doi: 10.19540/j.cnki.cjcmm.20170807.003. Chinese. PubMed PMID: 29235293.

2: Zhao ZY, Gao YY, Gao L, Zhang M, Wang H, Zhang CH. Protective effects of bellidifolin in hypoxia-induced in pheochromocytoma cells (PC12) and underlying mechanisms. J Toxicol Environ Health A. 2017;80(22):1187-1192. doi: 10.1080/15287394.2017.1367114. Epub 2017 Sep 12. PubMed PMID: 28895799.

3: Wang H, Yuan X, Huang H, Zhang B, Cao C, Zhao HP. Chemical constituents from Swertia mussotii Franch. (Gentianaceae). Nat Prod Res. 2017 Jul;31(14):1704-1708. doi: 10.1080/14786419.2017.1286480. Epub 2017 Feb 21. PubMed PMID: 28278647.

4: Kuang HX, Wu GS, Liu H, Yu Y, Wu Q, Wang QH, Yang BY, Wang ZB. [Isolation and identification of xanthones from Gentianella acuta]. Zhongguo Zhong Yao Za Zhi. 2016 Jun;41(12):2280-2283. doi: 10.4268/cjcmm20161218. Chinese. PubMed PMID: 28901073.

5: Wang Z, Wu Q, Yu Y, Yang C, Jiang H, Wang Q, Yang B, Kuang H. Determination and pharmacokinetic study of four xanthones in rat plasma after oral administration of Gentianella acuta extract by UHPLC-ESI-MS/MS. J Ethnopharmacol. 2015 Nov 4;174:261-9. doi: 10.1016/j.jep.2015.08.023. Epub 2015 Aug 20. PubMed PMID: 26297839.

6: Zheng XY, Yang YF, Li W, Zhao X, Sun Y, Sun H, Wang YH, Pu XP. Two xanthones from Swertia punicea with hepatoprotective activities in vitro and in vivo. J Ethnopharmacol. 2014 May 14;153(3):854-63. doi: 10.1016/j.jep.2014.03.058. Epub 2014 Mar 29. PubMed PMID: 24690777.

7: Kesavan R, Potunuru UR, Nastasijević B, T A, Joksić G, Dixit M. Inhibition of vascular smooth muscle cell proliferation by Gentiana lutea root extracts. PLoS One. 2013 Apr 18;8(4):e61393. doi: 10.1371/journal.pone.0061393. Print 2013. PubMed PMID: 23637826; PubMed Central PMCID: PMC3630200.

8: Lima B, Sánchez M, Luna L, Agüero MB, Zacchino S, Filippa E, Palermo JA, Tapia A, Feresin GE. Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean Slopes of San Juan Province, Argentina. Z Naturforsch C. 2012 Jan-Feb;67(1-2):29-38. PubMed PMID: 22486039.

9: Singh PP, Ambika, Chauhan SM. Activity-guided isolation of antioxidant xanthones from Swertia chirayita (Roxb.) H. Karsten (Gentianaceae). Nat Prod Res. 2012;26(18):1682-6. doi: 10.1080/14786419.2011.592836. Epub 2011 Oct 10. PubMed PMID: 21985644.

10: Tian LY, Bai X, Chen XH, Fang JB, Liu SH, Chen JC. Anti-diabetic effect of methylswertianin and bellidifolin from Swertia punicea Hemsl. and its potential mechanism. Phytomedicine. 2010 Jun;17(7):533-9. doi: 10.1016/j.phymed.2009.10.007. Epub 2009 Dec 3. PubMed PMID: 19962285.

11: Xu K, Shen J, Li F, Liu J, Liu G, Tan J, Tan G. [Determination of six active components in three species of genus Swertia by HPLC multiwavelength with detection]. Zhongguo Zhong Yao Za Zhi. 2009 Jun;34(11):1384-9. Chinese. PubMed PMID: 19771868.

12: Janković T, Savikin K, Menković N, Aljancić I, Leskovac A, Petrović S, Joksić G. Radioprotective effects of Gentianella austriaca fractions and polyphenolic constituents in human lymphocytes. Planta Med. 2008 Jun;74(7):736-40. doi: 10.1055/s-2008-1074524. Epub 2008 Apr 29. PubMed PMID: 18446672.

13: Urbain A, Marston A, Grilo LS, Bravo J, Purev O, Purevsuren B, Batsuren D, Reist M, Carrupt PA, Hostettmann K. Xanthones from Gentianella amarella ssp. acuta with acetylcholinesterase and monoamine oxidase inhibitory activities. J Nat Prod. 2008 May;71(5):895-7. doi: 10.1021/np070690l. Epub 2008 Mar 13. PubMed PMID: 18336006.

14: Qing Z, Jiachun C, Yanwen L. [Study on chemical constituents from Swertia kauitchensis Franch]. Zhong Yao Cai. 2004 Dec;27(12):908-10. Chinese. PubMed PMID: 15807240.

15: Hirakawa K, Yoshida M, Nagatsu A, Mizukami H, Rana V, Rawat MS, Oikawa S, Kawanishi S. Chemopreventive action of xanthone derivatives on photosensitized DNA damage. Photochem Photobiol. 2005 Mar-Apr;81(2):314-9. PubMed PMID: 15646999.

16: Urbain A, Marston A, Queiroz EF, Ndjoko K, Hostettmann K. Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors. Planta Med. 2004 Oct;70(10):1011-4. PubMed PMID: 15490334.

17: Menković N, Savikin-Fodulović K, Bulatović V, Aljancić I, Juranić N, Macura S, Vajs V, Milosavljević S. Xanthones from Swertia punctata. Phytochemistry. 2002 Oct;61(4):415-20. PubMed PMID: 12377236.

18: Basnet P, Kadota S, Shimizu M, Takata Y, Kobayashi M, Namba T. Bellidifolin stimulates glucose uptake in rat 1 fibroblasts and ameliorates hyperglycemia in streptozotocin (STZ)-induced diabetic rats. Planta Med. 1995 Oct;61(5):402-5. PubMed PMID: 7480198.

19: Basnet P, Kadota S, Shimizu M, Namba T. Bellidifolin: a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Planta Med. 1994 Dec;60(6):507-11. PubMed PMID: 7809201.

20: Matsushima T, Araki A, Yagame O, Muramatsu M, Koyama K, Ohsawa K, Natori S, Tomimori H. Mutagenicities of xanthone derivatives in Salmonella typhimurium TA100, TA98, TA97, and TA2637. Mutat Res. 1985 Jun-Jul;150(1-2):141-6. PubMed PMID: 3889613.