WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555228
Description: MDK-7933, also known as HDAC8-IN-1, is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). MDK-7933 was first reported in ChemMedChem. 2012 Oct;7(10):1815-24. MDK-7933 has CAS#1417997-93-3. For the convenience of scientific communication, we
MedKoo Cat#: 555228
Chemical Formula: C22H19NO3
Exact Mass: 345.1365
Molecular Weight: 345.398
Elemental Analysis: C, 76.50; H, 5.54; N, 4.06; O, 13.90
Synonym: HDAC8-IN-1; MDK-7933; MDK 7933; MDK7933.
IUPAC/Chemical Name: (E)-N-hydroxy-3-(5-methoxy-[1,1':4',1''-terphenyl]-2-yl)acrylamide
InChi Key: ASHPRZYGCOMVHO-WYMLVPIESA-N
InChi Code: InChI=1S/C22H19NO3/c1-26-20-13-11-19(12-14-22(24)23-25)21(15-20)18-9-7-17(8-10-18)16-5-3-2-4-6-16/h2-15,25H,1H3,(H,23,24)/b14-12+
SMILES Code: ONC(/C=C/C1=CC=C(C=C1C2=CC=C(C=C2)C3=CC=CC=C3)OC)=O
. Huang WJ, et al. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8 isoform-selective inhibitors. ChemMedChem. 2012 Oct;7(10):1815-24.