MDK-7933
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558272

CAS#: 1417997-93-3

Description: MDK-7933, also known as HDAC8-IN-1, is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). MDK-7933 was first reported in ChemMedChem. 2012 Oct;7(10):1815-24. MDK-7933 has CAS#1417997-93-3.


Price and Availability

Size
Price

100mg
USD 850
1g
USD 2950
Size
Price

200mg
USD 1450
2g
USD 4950
Size
Price

500mg
USD 1950
5g
USD 6950

MDK-7933, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 558272
Name: MDK-7933
CAS#: 1417997-93-3
Chemical Formula: C22H19NO3
Exact Mass: 345.1365
Molecular Weight: 345.398
Elemental Analysis: C, 76.50; H, 5.54; N, 4.06; O, 13.90


Synonym: HDAC8-IN-1; MDK-7933; MDK 7933; MDK7933.

IUPAC/Chemical Name: (E)-N-hydroxy-3-(5-methoxy-[1,1':4',1''-terphenyl]-2-yl)acrylamide

InChi Key: ASHPRZYGCOMVHO-WYMLVPIESA-N

InChi Code: InChI=1S/C22H19NO3/c1-26-20-13-11-19(12-14-22(24)23-25)21(15-20)18-9-7-17(8-10-18)16-5-3-2-4-6-16/h2-15,25H,1H3,(H,23,24)/b14-12+

SMILES Code: ONC(/C=C/C1=CC=C(C=C1C2=CC=C(C=C2)C3=CC=CC=C3)OC)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

For the convenience of scientific communication, we named as MDK-7933. The last four digit of CAS# was used for name


References

[1]. Huang WJ, et al. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8 isoform-selective inhibitors. ChemMedChem. 2012 Oct;7(10):1815-24.