MDK-7933
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558272

CAS#: 1417997-93-3

Description: MDK-7933, also known as HDAC8-IN-1, is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). MDK-7933 was first reported in ChemMedChem. 2012 Oct;7(10):1815-24. MDK-7933 has CAS#1417997-93-3.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 850
1g
USD 3450
Size
Price

25mg
USD 250
200mg
USD 1450
2g
USD 5450
Size
Price

50mg
USD 450
500mg
USD 1950

MDK-7933, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 500mg may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 558272
Name: MDK-7933
CAS#: 1417997-93-3
Chemical Formula: C22H19NO3
Exact Mass: 345.1365
Molecular Weight: 345.398
Elemental Analysis: C, 76.50; H, 5.54; N, 4.06; O, 13.90


Synonym: HDAC8-IN-1; MDK-7933; MDK 7933; MDK7933.

IUPAC/Chemical Name: (E)-N-hydroxy-3-(5-methoxy-[1,1':4',1''-terphenyl]-2-yl)acrylamide

InChi Key: ASHPRZYGCOMVHO-WYMLVPIESA-N

InChi Code: InChI=1S/C22H19NO3/c1-26-20-13-11-19(12-14-22(24)23-25)21(15-20)18-9-7-17(8-10-18)16-5-3-2-4-6-16/h2-15,25H,1H3,(H,23,24)/b14-12+

SMILES Code: ONC(/C=C/C1=CC=C(C=C1C2=CC=C(C=C2)C3=CC=CC=C3)OC)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


Additional Information

For the convenience of scientific communication, we named as MDK-7933. The last four digit of CAS# was used for name


References

[1]. Huang WJ, et al. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8 isoform-selective inhibitors. ChemMedChem. 2012 Oct;7(10):1815-24.