WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562480

CAS#: 475193-31-8

Description: 2-MeS-ADP is a purinergic agonist. It acts by displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors and inhibiting cAMP accumulation.

Chemical Structure

CAS# 475193-31-8

Theoretical Analysis

MedKoo Cat#: 562480
Name: 2-MeS-ADP
CAS#: 475193-31-8
Chemical Formula: C11H14N5Na3O10P2S
Exact Mass: 538.963
Molecular Weight: 539.23
Elemental Analysis: C, 24.50; H, 2.62; N, 12.99; Na, 12.79; O, 29.67; P, 11.49; S, 5.95

Price and Availability

Size Price Availability Quantity
5.0mg USD 320.0 2 Weeks
10.0mg USD 510.0 2 Weeks
Bulk inquiry

Synonym: 2-MeS-ADP; 2 MeS ADP; 2MeSADP; 2-Methylthio-ADP; 2 Methylthio ADP;

IUPAC/Chemical Name: 2-(Methylthio)adenosine 5'-diphosphate sodium salt


InChi Code: InChI=1S/C11H17N5O10P2S.3Na/c1-29-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(25-10)2-24-28(22,23)26-27(19,20)21;;;/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H2,12,14,15)(H2,19,20,21);;;/q;3*+1/p-3/t4-,6-,7-,10-;;;/m1.../s1

SMILES Code: O[C@@H]([C@H]([C@H](N1C=NC2=C(N=C(SC)N=C21)N)O3)O)[C@H]3COP([O-])(OP([O-])([O-])=O)=O.[Na+].[Na+].[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 539.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Gao ZG, Jacobson KA. Distinct Signaling Patterns of Allosteric Antagonism at the P2Y(1) Receptor. Mol Pharmacol. 2017 Nov;92(5):613-626. doi: 10.1124/mol.117.109660. Epub 2017 Sep 1. PubMed PMID: 28864555; PubMed Central PMCID: PMC5635520.

2: Muscella A, Cossa LG, Vetrugno C, Antonaci G, Marsigliante S. Inhibition of ZL55 cell proliferation by ADP via PKC-dependent signalling pathway. J Cell Physiol. 2018 Mar;233(3):2526-2536. doi: 10.1002/jcp.26128. Epub 2017 Sep 4. PubMed PMID: 28777435.

3: Guarracino JF, Cinalli AR, Fernández V, Roquel LI, Losavio AS. P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction. Neuroscience. 2016 Jun 21;326:31-44. doi: 10.1016/j.neuroscience.2016.03.066. Epub 2016 Apr 4. PubMed PMID: 27058149.

4: Förster D, Reiser G. Nucleotides protect rat brain astrocytes against hydrogen peroxide toxicity and induce antioxidant defense via P2Y receptors. Neurochem Int. 2016 Mar;94:57-66. doi: 10.1016/j.neuint.2016.02.006. Epub 2016 Feb 17. PubMed PMID: 26898403.

5: Rajasekhar P, Poole DP, Liedtke W, Bunnett NW, Veldhuis NA. P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells. J Biol Chem. 2015 Nov 27;290(48):29051-62. doi: 10.1074/jbc.M115.689729. Epub 2015 Oct 16. PubMed PMID: 26475857; PubMed Central PMCID: PMC4661417.

6: Kawaguchi A, Sato M, Kimura M, Ichinohe T, Tazaki M, Shibukawa Y. Expression and function of purinergic P2Y12 receptors in rat trigeminal ganglion neurons. Neurosci Res. 2015 Sep;98:17-27. doi: 10.1016/j.neures.2015.04.008. Epub 2015 May 15. PubMed PMID: 25987295.

7: Zhang D, Gao ZG, Zhang K, Kiselev E, Crane S, Wang J, Paoletta S, Yi C, Ma L, Zhang W, Han GW, Liu H, Cherezov V, Katritch V, Jiang H, Stevens RC, Jacobson KA, Zhao Q, Wu B. Two disparate ligand-binding sites in the human P2Y1 receptor. Nature. 2015 Apr 16;520(7547):317-21. doi: 10.1038/nature14287. Epub 2015 Mar 30. PubMed PMID: 25822790; PubMed Central PMCID: PMC4408927.

8: Thomas K, Cameron SA, Almo SC, Burgos ES, Gulab SA, Schramm VL. Active site and remote contributions to catalysis in methylthioadenosine nucleosidases. Biochemistry. 2015 Apr 21;54(15):2520-9. doi: 10.1021/bi501487w. Epub 2015 Apr 3. PubMed PMID: 25806409; PubMed Central PMCID: PMC4485437.

9: Michaelis M, Nieswandt B, Stegner D, Eilers J, Kraft R. STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia. Glia. 2015 Apr;63(4):652-63. doi: 10.1002/glia.22775. Epub 2014 Dec 3. PubMed PMID: 25471906.

10: Wang W, Luo J, Xiang F, Liu X, Jiang M, Liao L, Hu J. Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells. PLoS One. 2014 Oct 7;9(10):e110101. doi: 10.1371/journal.pone.0110101. eCollection 2014. PubMed PMID: 25290311; PubMed Central PMCID: PMC4188626.

11: Hoffmann K, Lutz DA, Straßburger J, Baqi Y, Müller CE, von Kügelgen I. Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12 -receptor. J Thromb Haemost. 2014 Nov;12(11):1898-905. doi: 10.1111/jth.12719. Epub 2014 Sep 29. PubMed PMID: 25186974.

12: Tatsumi E, Yamanaka H, Kobayashi K, Yagi H, Sakagami M, Noguchi K. RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain. Glia. 2015 Feb;63(2):216-28. doi: 10.1002/glia.22745. Epub 2014 Aug 14. PubMed PMID: 25130721.

13: Delesque-Touchard N, Pflieger AM, Bonnet-Lignon S, Millet L, Salel V, Boldron C, Lassalle G, Herbert JM, Savi P, Bono F. SAR216471, an alternative to the use of currently available P2Y₁₂ receptor inhibitors? Thromb Res. 2014 Sep;134(3):693-703. doi: 10.1016/j.thromres.2014.06.034. Epub 2014 Jul 11. PubMed PMID: 25064036.

14: Morente V, Pérez-Sen R, Ortega F, Huerta-Cepas J, Delicado EG, Miras-Portugal MT. Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery. Biochim Biophys Acta. 2014 Sep;1843(9):1886-98. doi: 10.1016/j.bbamcr.2014.05.004. Epub 2014 May 20. PubMed PMID: 24851838.

15: Mansfield KJ, Hughes JR. P2Y receptor modulation of ATP release in the urothelium. Biomed Res Int. 2014;2014:830374. doi: 10.1155/2014/830374. Epub 2014 Apr 14. PubMed PMID: 24829920; PubMed Central PMCID: PMC4009150.

16: Zhang J, Zhang K, Gao ZG, Paoletta S, Zhang D, Han GW, Li T, Ma L, Zhang W, Müller CE, Yang H, Jiang H, Cherezov V, Katritch V, Jacobson KA, Stevens RC, Wu B, Zhao Q. Agonist-bound structure of the human P2Y12 receptor. Nature. 2014 May 1;509(7498):119-22. doi: 10.1038/nature13288. PubMed PMID: 24784220; PubMed Central PMCID: PMC4128917.

17: Giachini FR, Leite R, Osmond DA, Lima VV, Inscho EW, Webb RC, Tostes RC. Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats. PLoS One. 2014 Mar 17;9(3):e91890. doi: 10.1371/journal.pone.0091890. eCollection 2014. PubMed PMID: 24638017; PubMed Central PMCID: PMC3956760.

18: Haas M, Shaaban A, Reiser G. Alanine-(87)-threonine polymorphism impairs signaling and internalization of the human P2Y11 receptor, when co-expressed with the P2Y1 receptor. J Neurochem. 2014 May;129(4):602-13. doi: 10.1111/jnc.12666. Epub 2014 Feb 13. PubMed PMID: 24524250.

19: Kim S, Dangelmaier C, Bhavanasi D, Meng S, Wang H, Goldfinger LE, Kunapuli SP. RhoG protein regulates glycoprotein VI-Fc receptor γ-chain complex-mediated platelet activation and thrombus formation. J Biol Chem. 2013 Nov 22;288(47):34230-8. doi: 10.1074/jbc.M113.504928. Epub 2013 Oct 8. PubMed PMID: 24106269; PubMed Central PMCID: PMC3837163.

20: Grześk G, Kozinski M, Tantry US, Wicinski M, Fabiszak T, Navarese EP, Grzesk E, Jeong YH, Gurbel PA, Kubica J. High-dose, but not low-dose, aspirin impairs anticontractile effect of ticagrelor following ADP stimulation in rat tail artery smooth muscle cells. Biomed Res Int. 2013;2013:928271. doi: 10.1155/2013/928271. Epub 2013 Jun 6. PubMed PMID: 23841099; PubMed Central PMCID: PMC3690229.