GC376 sodium
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555227

CAS#: 1416992-39-6 (sodium)

Description: GC376 is a 3CLpro inhibitor (3C-like protease inhibitor). GC376 showed promise in treating cats with certain presentations of FIP and has opened the door to targeted antiviral drug therapy.


Price and Availability

Size
Price

100mg
USD 1250
1g
USD 3650
Size
Price

200mg
USD 1850
2g
USD 5850
Size
Price

500mg
USD 2450
5g
USD 9650

GC376 sodium, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555227
Name: GC376 sodium
CAS#: 1416992-39-6 (sodium)
Chemical Formula: C21H30N3NaO8S
Exact Mass:
Molecular Weight: 507.5338
Elemental Analysis: C, 49.70; H, 5.96; N, 8.28; Na, 4.53; O, 25.22; S, 6.32


Related CAS #: 1416992-39-6 (sodium)   1417031-79-8 (free acid)    

Synonym: GC376; GC-376; GC 376; GC376 sodium.

IUPAC/Chemical Name: sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate

InChi Key: BSPJDKCMFIPBAW-JPBGFCRCSA-M

InChi Code: InChI=1S/C21H31N3O8S.Na/c1-13(2)10-16(24-21(28)32-12-14-6-4-3-5-7-14)19(26)23-17(20(27)33(29,30)31)11-15-8-9-22-18(15)25;/h3-7,13,15-17,20,27H,8-12H2,1-2H3,(H,22,25)(H,23,26)(H,24,28)(H,29,30,31);/q;+1/p-1/t15?,16-,17-,20?;/m0./s1

SMILES Code: O=S(C(O)[C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)CC2C(NCC2)=O)([O-])=O.[Na+]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Pedersen NC, Kim Y, Liu H, Galasiti Kankanamalage AC, Eckstrand C, Groutas WC,
Bannasch M, Meadows JM, Chang KO. Efficacy of a 3C-like protease inhibitor in
treating various forms of acquired feline infectious peritonitis. J Feline Med
Surg. 2018 Apr;20(4):378-392. doi: 10.1177/1098612X17729626. Epub 2017 Sep 13.
PubMed PMID: 28901812; PubMed Central PMCID: PMC5871025.

2: Takahashi D, Kim Y, Lovell S, Prakash O, Groutas WC, Chang KO. Structural and
inhibitor studies of norovirus 3C-like proteases. Virus Res. 2013 Dec
26;178(2):437-44. doi: 10.1016/j.virusres.2013.09.008. Epub 2013 Sep 17. PubMed
PMID: 24055466; PubMed Central PMCID: PMC3840063.

3: Kim Y, Lovell S, Tiew KC, Mandadapu SR, Alliston KR, Battaile KP, Groutas WC,
Chang KO. Broad-spectrum antivirals against 3C or 3C-like proteases of
picornaviruses, noroviruses, and coronaviruses. J Virol. 2012
Nov;86(21):11754-62. doi: 10.1128/JVI.01348-12. Epub 2012 Aug 22. PubMed PMID:
22915796; PubMed Central PMCID: PMC3486288.