LX-2343
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555226

CAS#: 333745-53-2

Description: LX-2343 is a neuroprotective agent for the treatment of Alzheimer's disease. LX2343 ameliorates cognitive dysfunction in APP/PS1 transgenic mice via both Aβ production inhibition and clearance promotion, which highlights the potential of LX2343 in the treatment of AD. LX2343 ameliorates the cognitive dysfunction in the AD model rats by suppressing OS-induced neuronal apoptosis and tauopathy, thus highlighting the potential of LX2343 for the treatment of AD.


Price and Availability

Size
Price

100mg
USD 850
1g
USD 2950
Size
Price

200mg
USD 1450
2g
USD 4250
Size
Price

500mg
USD 1950
5g
USD 7450

LX-2343, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555226
Name: LX-2343
CAS#: 333745-53-2
Chemical Formula: C22H19ClN2O6S
Exact Mass: 474.0652
Molecular Weight: 474.912
Elemental Analysis: C, 55.64; H, 4.03; Cl, 7.46; N, 5.90; O, 20.21; S, 6.75


Synonym: LX-2343; LX 2343; LX2343.

IUPAC/Chemical Name: N-(benzo[d][1,3]dioxol-5-yl)-2-(N-(5-chloro-2-methoxyphenyl)phenylsulfonamido)acetamide

InChi Key: ZGYSGIYKAVUVOR-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H19ClN2O6S/c1-29-19-9-7-15(23)11-18(19)25(32(27,28)17-5-3-2-4-6-17)13-22(26)24-16-8-10-20-21(12-16)31-14-30-20/h2-12H,13-14H2,1H3,(H,24,26)

SMILES Code: C1=C(NC(CN(C2=CC(Cl)=CC=C2OC)S(C2=CC=CC=C2)(=O)=O)=O)C=C2OCOC2=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Sun G, Wang J, Guo X, Lei M, Zhang Y, Wang X, Shen X, Hu L. Design, synthesis
and biological evaluation of LX2343 derivatives as neuroprotective agents for the
treatment of Alzheimer's disease. Eur J Med Chem. 2018 Feb 10;145:622-633. doi:
10.1016/j.ejmech.2017.12.080. Epub 2018 Jan 2. PubMed PMID: 29339255.

2: Guo XD, Sun GL, Zhou TT, Wang YY, Xu X, Shi XF, Zhu ZY, Rukachaisirikul V, Hu
LH, Shen X. LX2343 alleviates cognitive impairments in AD model rats by
inhibiting oxidative stress-induced neuronal apoptosis and tauopathy. Acta
Pharmacol Sin. 2017 Aug;38(8):1104-1119. doi: 10.1038/aps.2016.128. Epub 2017 Jun
26. PubMed PMID: 28649128; PubMed Central PMCID: PMC5547549.

3: Guo XD, Sun GL, Zhou TT, Xu X, Zhu ZY, Rukachaisirikul V, Hu LH, Shen X. Small
molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both
amyloid β production and clearance. Acta Pharmacol Sin. 2016
Sep;37(10):1281-1297. doi: 10.1038/aps.2016.80. Epub 2016 Aug 29. PubMed PMID:
27569389; PubMed Central PMCID: PMC5057240.