HSF1A
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555224

CAS#: 1196723-93-9

Description: HSF1A is an activator of Heat shock transcription factor 1 (HSF1).


Price and Availability

Size
Price

100mg
USD 1650
1g
USD 3450
Size
Price

200mg
USD 2150
2g
USD 5250
Size
Price

500mg
USD 2650
5g
USD 8950

HSF1A, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555224
Name: HSF1A
CAS#: 1196723-93-9
Chemical Formula: C21H19N3O2S2
Exact Mass: 409.0919
Molecular Weight: 409.522
Elemental Analysis: C, 61.59; H, 4.68; N, 10.26; O, 7.81; S, 15.66


Synonym: HSF1A;

IUPAC/Chemical Name: 4-Ethyl-N-[1-phenyl-3-(2-thienyl)-1H-pyrazol-5-yl]-benzenesulfonamide

InChi Key: KJTITGSAONQVPY-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H19N3O2S2/c1-2-16-10-12-18(13-11-16)28(25,26)23-21-15-19(20-9-6-14-27-20)22-24(21)17-7-4-3-5-8-17/h3-15,23H,2H2,1H3

SMILES Code: O=S(C1=CC=C(CC)C=C1)(NC2=CC(C3=CC=CS3)=NN2C4=CC=CC=C4)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Huang CY, Kuo WW, Lo JF, Ho TJ, Pai PY, Chiang SF, Chen PY, Tsai FJ, Tsai CH, Huang CY. Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death. Cell Death Dis. 2016 Nov 3;7(11):e2455. doi: 10.1038/cddis.2016.356. PubMed PMID: 27809308; PubMed Central PMCID: PMC5260882.

2: Bocchini CE, Nahmod K, Katsonis P, Kim S, Kasembeli MM, Freeman A, Lichtarge O, Makedonas G, Tweardy DJ. Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome. Blood. 2016 Dec 29;128(26):3061-3072. doi: 10.1182/blood-2016-02-702373. Epub 2016 Oct 31. PubMed PMID: 27799162; PubMed Central PMCID: PMC5201093.

3: Neef DW, Jaeger AM, Gomez-Pastor R, Willmund F, Frydman J, Thiele DJ. A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. Cell Rep. 2014 Nov 6;9(3):955-66. doi: 10.1016/j.celrep.2014.09.056. Epub 2014 Oct 30. PubMed PMID: 25437552; PubMed Central PMCID: PMC4488849.

4: Kawabe S, Yokoyama Y. Novel isoforms of heat shock transcription factor 1 are induced by hypoxia in the Pacific oyster Crassostrea gigas. J Exp Zool A Ecol Genet Physiol. 2011 Aug 1;315(7):394-407. doi: 10.1002/jez.685. Epub 2011 Mar 31. PubMed PMID: 21455948.

5: Neef DW, Turski ML, Thiele DJ. Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. PLoS Biol. 2010 Jan 19;8(1):e1000291. doi: 10.1371/journal.pbio.1000291. PubMed PMID: 20098725; PubMed Central PMCID: PMC2808216.

6: Ojima N, Yamashita M. Cloning and characterization of two distinct isoforms of rainbow trout heat shock factor 1. Evidence for heterotrimer formation. Eur J Biochem. 2004 Feb;271(4):703-12. PubMed PMID: 14764086.

7: Airaksinen S, Jokilehto T, Råbergh CM, Nikinmaa M. Heat- and cold-inducible regulation of HSP70 expression in zebrafish ZF4 cells. Comp Biochem Physiol B Biochem Mol Biol. 2003 Oct;136(2):275-82. PubMed PMID: 14529753.

8: Murtha JM, Keller ET. Characterization of the heat shock response in mature zebrafish (Danio rerio). Exp Gerontol. 2003 Jun;38(6):683-91. PubMed PMID: 12814804.