E6446 HCl
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555222

CAS#: 1345675-25-3 (HCl)

Description: E6446 is a synthetic antagonist of nucleic acid-sensing TLRs. , In vitro, low doses of E6446 specifically inhibited the activation of human and mouse TLR9. Tenfold higher concentrations of this compound also inhibited the human TLR8 response to single-stranded RNA. In vivo, therapy with E6446 diminished the activation of TLR9 and prevented the exacerbated cytokine response observed during acute Plasmodium infection. Furthermore, severe signs of ECM, such as limb paralysis, brain vascular leak, and death, were all prevented by oral treatment with E6446.


Price and Availability

Size
Price

200mg
USD 1950
2g
USD 5250
Size
Price

500mg
USD 2850
5g
USD 7250
Size
Price

1g
USD 3450

E6446 HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555222
Name: E6446 HCl
CAS#: 1345675-25-3 (HCl)
Chemical Formula: C27H37Cl2N3O3
Exact Mass:
Molecular Weight: 522.511
Elemental Analysis: C, 62.07; H, 7.14; Cl, 13.57; N, 8.04; O, 9.19


Related CAS #: 1219925-73-1 (free base)   1345675-25-3 (HCl)    

Synonym: E6446 HCl; E6446; E-6446; E6446 hydrochloride

IUPAC/Chemical Name: 6-(3-pyrrolidin-1-ylpropoxy)-2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1,3-benzoxazole;dihydrochloride

InChi Key: DQOUZINBHKWGGM-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H35N3O3.2ClH/c1-2-14-29(13-1)17-5-19-31-23-9-7-22(8-10-23)27-28-25-12-11-24(21-26(25)33-27)32-20-6-18-30-15-3-4-16-30;;/h7-12,21H,1-6,13-20H2;2*1H

SMILES Code: [H]Cl.[H]Cl.C1(C2=CC=C(OCCCN3CCCC3)C=C2)=NC4=CC=C(OCCCN5CCCC5)C=C4O1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Franklin BS, Ishizaka ST, Lamphier M, Gusovsky F, Hansen H, Rose J, Zheng W,
Ataíde MA, de Oliveira RB, Golenbock DT, Gazzinelli RT. Therapeutical targeting
of nucleic acid-sensing Toll-like receptors prevents experimental cerebral
malaria. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94. doi:
10.1073/pnas.1015406108. Epub 2011 Feb 8. PubMed PMID: 21303985; PubMed Central
PMCID: PMC3048158.