KIN-1148
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555218

CAS#: 1428729-56-9

Description: KIN-1148 is a IRF3 agonist. IN1148 induced dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. Prime-boost immunization of mice with a suboptimal dose of a monovalent pandemic influenza split virus H1N1 A/California/07/2009 vaccine plus KIN1148 protected against a lethal challenge with mouse-adapted influenza virus (A/California/04/2009) and induced an influenza virus-specific IL-10 and Th2 response by T cells derived from lung and lung-draining lymph nodes.


Price and Availability

Size
Price

100mg
USD 1050
1g
USD 3250
Size
Price

200mg
USD 1650
2g
USD 5450
Size
Price

500mg
USD 2150
5g
USD 7650

KIN-1148, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555218
Name: KIN-1148
CAS#: 1428729-56-9
Chemical Formula: C19H11N3OS2
Exact Mass: 361.0344
Molecular Weight: 361.437
Elemental Analysis: C, 63.14; H, 3.07; N, 11.63; O, 4.43; S, 17.74


Synonym: KIN-1148; KIN 1148; KIN1148.

IUPAC/Chemical Name: N-(benzo[1,2-d:3,4-d']bis(thiazole)-2-yl)-2-naphthamide

InChi Key: YAISOECYKYATLL-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H11N3OS2/c23-18(13-6-5-11-3-1-2-4-12(11)9-13)22-19-21-14-7-8-15-16(17(14)25-19)20-10-24-15/h1-10H,(H,21,22,23)

SMILES Code: O=C(NC1=NC2=CC=C(SC=N3)C3=C2S1)C4=CC=C5C=CC=CC5=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Probst P, Grigg JB, Wang M, Muñoz E, Loo YM, Ireton RC, Gale M Jr, Iadonato
SP, Bedard KM. A small-molecule IRF3 agonist functions as an influenza vaccine
adjuvant by modulating the antiviral immune response. Vaccine. 2017 Apr
4;35(15):1964-1971. doi: 10.1016/j.vaccine.2017.01.053. Epub 2017 Mar 6. PubMed
PMID: 28279563.