HMN-154 | CAS#173528-92-2

HMN-154
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555217

CAS#: 173528-92-2

Description: HMN-154 is a benzenesulfonamide anticancer agent. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner.

Chemical Structure

HMN-154

CAS# 173528-92-2

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 555217
Name: HMN-154
CAS#: 173528-92-2
Chemical Formula: C20H18N2O3S
Exact Mass: 366.10
Molecular Weight: 366.435
Elemental Analysis: C, 65.56; H, 4.95; N, 7.65; O, 13.10; S, 8.75

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 950
200mg	USD 1450
500mg	USD 1950
1g	USD 2950
2g	USD 4650
5g	USD 7250
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: HMN-154; HMN 154; HMN154.

IUPAC/Chemical Name: (E)-4-(2-(2-(N-(4-Methoxybenzenesulfonyl)amino)phenyl)ethenyl)pyridine

InChi Key: CIJCDFMGZYKSSC-VOTSOKGWSA-N

InChi Code: InChI=1S/C20H18N2O3S/c1-25-18-8-10-19(11-9-18)26(23,24)22-20-5-3-2-4-17(20)7-6-16-12-14-21-15-13-16/h2-15,22H,1H3/b7-6+

SMILES Code: O=S(NC1=CC=CC=C1/C=C/C2=CC=NC=C2)(C3=CC=C(OC)C=C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

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Biological target:	HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively.
In vitro activity:	Furthermore, HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. Reference: Mol Pharmacol. 1999 Feb;55(2):356-63. https://pubmed.ncbi.nlm.nih.gov/9927629/
In vivo activity:	TBD

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	15.0	40.93

Preparing Stock Solutions

The following data is based on the product molecular weight 366.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Tanaka H, Ohshima N, Hidaka H. Isolation of cDNAs encoding cellular drug-binding proteins using a novel expression cloning procedure: drug-western. Mol Pharmacol. 1999 Feb;55(2):356-63. doi: 10.1124/mol.55.2.356. PMID: 9927629.
In vitro protocol:	1. Tanaka H, Ohshima N, Hidaka H. Isolation of cDNAs encoding cellular drug-binding proteins using a novel expression cloning procedure: drug-western. Mol Pharmacol. 1999 Feb;55(2):356-63. doi: 10.1124/mol.55.2.356. PMID: 9927629.
In vivo protocol:	TBD

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1: Tanaka H, Ohshima N, Hidaka H. Isolation of cDNAs encoding cellular
drug-binding proteins using a novel expression cloning procedure: drug-western.
Mol Pharmacol. 1999 Feb;55(2):356-63. PubMed PMID: 9927629.

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HMN-154 featured