Endoxifen E-isomer HCl
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555212

CAS#: 1197194-61-8 (HCl)

Description: Endoxifen E-isomer is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).


Price and Availability

Size
Price

100mg
USD 950
1g
USD 3250
Size
Price

200mg
USD 1450
2g
USD 5450
Size
Price

500mg
USD 2150
5g
USD 7450

Endoxifen E-isomer HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 555212
Name: Endoxifen E-isomer HCl
CAS#: 1197194-61-8 (HCl)
Chemical Formula: C25H28ClNO2
Exact Mass:
Molecular Weight: 409.954
Elemental Analysis: C, 73.25; H, 6.88; Cl, 8.65; N, 3.42; O, 7.81


Related CAS #: 114828-90-9 (free base)   1197194-61-8 (HCl)    

Synonym: Endoxifen E-isomer HCl;

IUPAC/Chemical Name: 4-[(E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol;hydrochloride

InChi Key: RPFIMPDXTABYCN-QREUMGABSA-N

InChi Code: InChI=1S/C25H27NO2.ClH/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2;/h4-16,26-27H,3,17-18H2,1-2H3;1H/b25-24+;

SMILES Code: OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)/CC)C=C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Ford BM, Franks LN, Radominska-Pandya A, Prather PL. Tamoxifen Isomers and
Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors:
Potential Scaffold for Drug Development. PLoS One. 2016 Dec 9;11(12):e0167240.
doi: 10.1371/journal.pone.0167240. eCollection 2016. PubMed PMID: 27936172;
PubMed Central PMCID: PMC5147891.

2: Elkins P, Coleman D, Burgess J, Gardner M, Hines J, Scott B, Kroenke M, Larson
J, Lightner M, Turner G, White J, Liu P. Characterization of the
isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution
LC⬜MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9.
doi: 10.1016/j.jpba.2013.07.010. Epub 2013 Jul 24. PubMed PMID: 24055701; PubMed
Central PMCID: PMC4057282.

3: Fauq AH, Maharvi GM, Sinha D. A convenient synthesis of
(Z)-4-hydroxy-N-desmethyltamoxifen (endoxifen). Bioorg Med Chem Lett. 2010 May
15;20(10):3036-8. doi: 10.1016/j.bmcl.2010.03.117. Epub 2010 Apr 3. PubMed PMID:
20400308.