RI-1
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MedKoo CAT#: 407511

CAS#: 415713-60-9

Description: RI-1 is an irreversible inhibitor of RAD51 (IC50s = 5-30 µM), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types. RI-1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into filaments on DNA. RI-1 holds promise as an oncologic drug. Furthermore, RI-1 represents a unique tool to dissect the network of reaction pathways that contribute to DNA repair in cells.


Price and Availability

Size
Price

25mg
USD 150
200mg
USD 750
2g
USD 3850
Size
Price

50mg
USD 250
500mg
USD 1450
5g
USD 5950
Size
Price

100mg
USD 450
1g
USD 2450

RI-1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407511
Name: RI-1
CAS#: 415713-60-9
Chemical Formula: C14H11Cl3N2O3
Exact Mass: 359.9835
Molecular Weight: 361.603
Elemental Analysis: C, 46.50; H, 3.07; Cl, 29.41; N, 7.75; O, 13.27


Synonym: RI-1; RI1; RI 1.

IUPAC/Chemical Name: 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

InChi Key: MWSUIZKGNWELRF-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H11Cl3N2O3/c15-9-2-1-8(7-10(9)16)19-13(20)11(17)12(14(19)21)18-3-5-22-6-4-18/h1-2,7H,3-6H2

SMILES Code: O=C(C(Cl)=C1N2CCOCC2)N(C3=CC=C(Cl)C(Cl)=C3)C1=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Budke B, Logan HL, Kalin JH, Zelivianskaia AS, Cameron McGuire W, Miller LL,
Stark JM, Kozikowski AP, Bishop DK, Connell PP. RI-1: a chemical inhibitor of
RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res.
2012 Aug;40(15):7347-57. doi: 10.1093/nar/gks353. Epub 2012 May 9. PubMed PMID:
22573178; PubMed Central PMCID: PMC3424541.

2: Golec P, Wiczk A, Majchrzyk A, Łoś JM, Węgrzyn G, Łoś M. A role for accessory
genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4.
Virus Genes. 2010 Dec;41(3):459-68. doi: 10.1007/s11262-010-0532-1. Epub 2010 Oct
14. PubMed PMID: 20945083; PubMed Central PMCID: PMC2962797.

3: Bartmann P, Bamberger U, Pohlandt F, Gortner L. Immunogenicity and
immunomodulatory activity of bovine surfactant (SF-RI 1). Acta Paediatr. 1992
May;81(5):383-8. PubMed PMID: 1498502.